Cadmium-induced glutathionylation of actin occurs through a ROS-independent mechanism: Implications for cytoskeletal integrity

Cadmium disrupts the actin cytoskeleton in rat mesangial cells, and we have previously shown that this involves a complex interplay involving activation of kinase signaling, protein translocation, and disruption of focal adhesions. Here we investigate the role that glutathionylation of actin plays i...

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Veröffentlicht in:	Toxicology and applied pharmacology 2013-10, Vol.272 (2), p.423-430
Hauptverfasser:	Choong, Grace, Liu, Ying, Xiao, Weiqun, Templeton, Douglas M.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ACTIN Actin cytoskeleton Actins - metabolism Animals Biological and medical sciences Blotting, Western CADMIUM Cadmium Chloride - toxicity Cell Culture Techniques Cells, Cultured Chemical and industrial products toxicology. Toxic occupational diseases CONCENTRATION RATIO Cytoskeleton - drug effects Cytoskeleton - enzymology Cytoskeleton - metabolism Cytoskeleton - pathology Dose-Response Relationship, Drug Environmental Pollutants - toxicity ENZYMES Glutaredoxin Glutaredoxins - metabolism GLUTATHIONE Glutathione - metabolism Glutathionylation Medical sciences Mesangial cell Mesangial Cells - drug effects Mesangial Cells - enzymology Mesangial Cells - metabolism Mesangial Cells - pathology METABOLISM Metals and various inorganic compounds MICROTUBULES OXYGEN POLYMERIZATION RATS Reactive oxygen species Reactive Oxygen Species - metabolism THIOLS Time Factors Toxicology
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