A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity

Drug-induced liver injury (DILI) is the major cause for liver failure and post-marketing drug withdrawals. Due to species-specific differences in hepatocellular function, animal experiments to assess potential liabilities of drug candidates can predict hepatotoxicity in humans only to a certain exte...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Toxicology and applied pharmacology 2013-04, Vol.268 (1), p.1-16
Hauptverfasser:	Kostadinova, Radina, Boess, Franziska, Applegate, Dawn, Suter, Laura, Weiser, Thomas, Singer, Thomas, Naughton, Brian, Roth, Adrian
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Adult Albumins - metabolism Animals BILE Biological and medical sciences CELL CULTURES Cell Survival - drug effects Coculture Techniques - methods COMPARATIVE EVALUATIONS Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 Drug Evaluation, Preclinical - methods Drug safety assessment Drug toxicity and drugs side effects treatment Drug-induced liver injury DRUGS Endothelial Cells - cytology Endothelial Cells - metabolism Enzyme Inhibitors - pharmacology FIBRINOGEN Fibrinogen - metabolism Hepatocytes - cytology Hepatocytes - drug effects Hepatocytes - metabolism HUMAN POPULATIONS Humans Idiosyncratic toxicity IN VITRO IN VIVO LIVER Liver - cytology Liver - drug effects Liver - metabolism LIVER CELLS Male Medical sciences Middle Aged Pharmacology. Drug treatments Predictive toxicology RATS Rats, Wistar RISK ASSESSMENT Three-dimensional liver co-cultures TOXICITY Toxicity: digestive system TRANSFERRIN Transferrin - metabolism UREA Urea - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!