Deficiency in Homologous Recombination Renders Mammalian Cells More Sensitive to Proton Versus Photon Irradiation

Purpose To investigate the impact of the 2 major DNA repair machineries on cellular survival in response to irradiation with the 2 types of ionizing radiation. Methods and Materials The DNA repair and cell survival endpoints in wild-type, homologous recombination (HR)-deficient, and nonhomologous en...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2014, Vol.88 (1), p.175-181
Hauptverfasser:	Grosse, Nicole, PhD, Fontana, Andrea O., MSc, Hug, Eugen B., MD, Lomax, Antony, PhD, Coray, Adolf, PhD, Augsburger, Marc, MSc, Paganetti, Harald, PhD, Sartori, Alessandro A., PhD, Pruschy, Martin, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Survival - physiology Cell Survival - radiation effects CHO Cells CHROMOSOMAL ABERRATIONS Chromosome Aberrations Cricetulus DNA Breaks, Double-Stranded DNA DAMAGES DNA REPAIR DNA Repair - physiology DNA Repair - radiation effects Hematology, Oncology and Palliative Medicine Homologous Recombination - physiology Homologous Recombination - radiation effects IRRADIATION KEV RANGE 100-1000 Microscopy, Fluorescence Photons PROTON BEAMS Protons Radiation Tolerance - genetics Radiology RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY RBE Relative Biological Effectiveness Transfection - methods
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