An Anatomically Validated Brachial Plexus Contouring Method for Intensity Modulated Radiation Therapy Planning
Purpose To develop contouring guidelines for the brachial plexus (BP) using anatomically validated cadaver datasets. Magnetic resonance imaging (MRI) and computed tomography (CT) were used to obtain detailed visualizations of the BP region, with the goal of achieving maximal inclusion of the actual...
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| Veröffentlicht in: | International journal of radiation oncology, biology, physics biology, physics, 2013-11, Vol.87 (4), p.802-808 |
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| creator | Van de Velde, Joris, MSc Audenaert, Emmanuel, MD, PhD Speleers, Bruno, MSc Vercauteren, Tom, MSc Mulliez, Thomas, MD Vandemaele, Pieter, Ir Achten, Eric, MD, PhD Kerckaert, Ingrid, MD, PhD D'Herde, Katharina, MD, PhD De Neve, Wilfried, MD, PhD Van Hoof, Tom, MSc, PhD |
| description | Purpose To develop contouring guidelines for the brachial plexus (BP) using anatomically validated cadaver datasets. Magnetic resonance imaging (MRI) and computed tomography (CT) were used to obtain detailed visualizations of the BP region, with the goal of achieving maximal inclusion of the actual BP in a small contoured volume while also accommodating for anatomic variations. Methods and Materials CT and MRI were obtained for 8 cadavers positioned for intensity modulated radiation therapy. 3-dimensional reconstructions of soft tissue (from MRI) and bone (from CT) were combined to create 8 separate enhanced CT project files. Dissection of the corresponding cadavers anatomically validated the reconstructions created. Seven enhanced CT project files were then automatically fitted, separately in different regions, to obtain a single dataset of superimposed BP regions that incorporated anatomic variations. From this dataset, improved BP contouring guidelines were developed. These guidelines were then applied to the 7 original CT project files and also to 1 additional file, left out from the superimposing procedure. The percentage of BP inclusion was compared with the published guidelines. Results The anatomic validation procedure showed a high level of conformity for the BP regions examined between the 3-dimensional reconstructions generated and the dissected counterparts. Accurate and detailed BP contouring guidelines were developed, which provided corresponding guidance for each level in a clinical dataset. An average margin of 4.7 mm around the anatomically validated BP contour is sufficient to accommodate for anatomic variations. Using the new guidelines, 100% inclusion of the BP was achieved, compared with a mean inclusion of 37.75% when published guidelines were applied. Conclusion Improved guidelines for BP delineation were developed using combined MRI and CT imaging with validation by anatomic dissection. |
| doi_str_mv | 10.1016/j.ijrobp.2013.08.004 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_osti_</sourceid><recordid>TN_cdi_osti_scitechconnect_22267952</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S036030161302960X</els_id><sourcerecordid>1687661084</sourcerecordid><originalsourceid>FETCH-LOGICAL-c478t-a365bdf55504d5280dadb87e6121c00f44453a6177e5ecff72778c3335de18a43</originalsourceid><addsrcrecordid>eNqFks1u1DAUhSMEokPhDRCKxIZNBv_GzgZpGPFTqRUICurO8tg3jEPGHmwHMW-PQwoLNl15851zff25qp5itMYIty-HtRti2B3XBGG6RnKNELtXrbAUXUM5v7lfrRBtUUMLfFY9SmlACGEs2MPqjDBMZYe7VeU3vt54ncPBGT2Op_qrHp3VGWz9Omqzd3qsP47wa0r1Nvgcpuj8t_oK8j7Yug-xvvAZfHL5VF8FO41_kp-0dTq74OvrPUR9PJUK7X1JPq4e9HpM8OT2PK--vH1zvX3fXH54d7HdXDaGCZkbTVu-sz3nHDHLiURW250U0GKCDUI9Y4xT3WIhgIPpe0GEkIZSyi1gqRk9r54vvSFlp5JxGczeBO_BZEUIaUXHSaFeLNQxhh8TpKwOLhkYy2UhTEnhVoq2xUiyu1HGaNd1lM6tbEFNDClF6NUxuoOOJ4WRmtWpQS3q1KxOIamKuhJ7djth2h3A_gv9dVWAVwsA5eF-OojzXuANWBfntWxwd034v8CMzs_ev8MJ0lDk-iJFYZWIQurz_H3m34MpIl2LbuhvNGTAsw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1443999332</pqid></control><display><type>article</type><title>An Anatomically Validated Brachial Plexus Contouring Method for Intensity Modulated Radiation Therapy Planning</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Van de Velde, Joris, MSc ; Audenaert, Emmanuel, MD, PhD ; Speleers, Bruno, MSc ; Vercauteren, Tom, MSc ; Mulliez, Thomas, MD ; Vandemaele, Pieter, Ir ; Achten, Eric, MD, PhD ; Kerckaert, Ingrid, MD, PhD ; D'Herde, Katharina, MD, PhD ; De Neve, Wilfried, MD, PhD ; Van Hoof, Tom, MSc, PhD</creator><creatorcontrib>Van de Velde, Joris, MSc ; Audenaert, Emmanuel, MD, PhD ; Speleers, Bruno, MSc ; Vercauteren, Tom, MSc ; Mulliez, Thomas, MD ; Vandemaele, Pieter, Ir ; Achten, Eric, MD, PhD ; Kerckaert, Ingrid, MD, PhD ; D'Herde, Katharina, MD, PhD ; De Neve, Wilfried, MD, PhD ; Van Hoof, Tom, MSc, PhD</creatorcontrib><description>Purpose To develop contouring guidelines for the brachial plexus (BP) using anatomically validated cadaver datasets. Magnetic resonance imaging (MRI) and computed tomography (CT) were used to obtain detailed visualizations of the BP region, with the goal of achieving maximal inclusion of the actual BP in a small contoured volume while also accommodating for anatomic variations. Methods and Materials CT and MRI were obtained for 8 cadavers positioned for intensity modulated radiation therapy. 3-dimensional reconstructions of soft tissue (from MRI) and bone (from CT) were combined to create 8 separate enhanced CT project files. Dissection of the corresponding cadavers anatomically validated the reconstructions created. Seven enhanced CT project files were then automatically fitted, separately in different regions, to obtain a single dataset of superimposed BP regions that incorporated anatomic variations. From this dataset, improved BP contouring guidelines were developed. These guidelines were then applied to the 7 original CT project files and also to 1 additional file, left out from the superimposing procedure. The percentage of BP inclusion was compared with the published guidelines. Results The anatomic validation procedure showed a high level of conformity for the BP regions examined between the 3-dimensional reconstructions generated and the dissected counterparts. Accurate and detailed BP contouring guidelines were developed, which provided corresponding guidance for each level in a clinical dataset. An average margin of 4.7 mm around the anatomically validated BP contour is sufficient to accommodate for anatomic variations. Using the new guidelines, 100% inclusion of the BP was achieved, compared with a mean inclusion of 37.75% when published guidelines were applied. Conclusion Improved guidelines for BP delineation were developed using combined MRI and CT imaging with validation by anatomic dissection.</description><identifier>ISSN: 0360-3016</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/j.ijrobp.2013.08.004</identifier><identifier>PMID: 24138919</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Brachial Plexus - anatomy & histology ; Brachial Plexus - diagnostic imaging ; Cadaver ; COMPUTERIZED TOMOGRAPHY ; Female ; Hematology, Oncology and Palliative Medicine ; Humans ; Imaging, Three-Dimensional - methods ; Magnetic Resonance Imaging - methods ; Male ; Medical Illustration ; NMR IMAGING ; Patient Positioning - methods ; PLANNING ; Practice Guidelines as Topic - standards ; Radiology ; RADIOLOGY AND NUCLEAR MEDICINE ; RADIOTHERAPY ; Radiotherapy Planning, Computer-Assisted - methods ; Radiotherapy, Intensity-Modulated - methods ; RECOMMENDATIONS ; THREE-DIMENSIONAL CALCULATIONS ; Tomography, X-Ray Computed - methods</subject><ispartof>International journal of radiation oncology, biology, physics, 2013-11, Vol.87 (4), p.802-808</ispartof><rights>Elsevier Inc.</rights><rights>2013 Elsevier Inc.</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-a365bdf55504d5280dadb87e6121c00f44453a6177e5ecff72778c3335de18a43</citedby><cites>FETCH-LOGICAL-c478t-a365bdf55504d5280dadb87e6121c00f44453a6177e5ecff72778c3335de18a43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S036030161302960X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24138919$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/22267952$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Van de Velde, Joris, MSc</creatorcontrib><creatorcontrib>Audenaert, Emmanuel, MD, PhD</creatorcontrib><creatorcontrib>Speleers, Bruno, MSc</creatorcontrib><creatorcontrib>Vercauteren, Tom, MSc</creatorcontrib><creatorcontrib>Mulliez, Thomas, MD</creatorcontrib><creatorcontrib>Vandemaele, Pieter, Ir</creatorcontrib><creatorcontrib>Achten, Eric, MD, PhD</creatorcontrib><creatorcontrib>Kerckaert, Ingrid, MD, PhD</creatorcontrib><creatorcontrib>D'Herde, Katharina, MD, PhD</creatorcontrib><creatorcontrib>De Neve, Wilfried, MD, PhD</creatorcontrib><creatorcontrib>Van Hoof, Tom, MSc, PhD</creatorcontrib><title>An Anatomically Validated Brachial Plexus Contouring Method for Intensity Modulated Radiation Therapy Planning</title><title>International journal of radiation oncology, biology, physics</title><addtitle>Int J Radiat Oncol Biol Phys</addtitle><description>Purpose To develop contouring guidelines for the brachial plexus (BP) using anatomically validated cadaver datasets. Magnetic resonance imaging (MRI) and computed tomography (CT) were used to obtain detailed visualizations of the BP region, with the goal of achieving maximal inclusion of the actual BP in a small contoured volume while also accommodating for anatomic variations. Methods and Materials CT and MRI were obtained for 8 cadavers positioned for intensity modulated radiation therapy. 3-dimensional reconstructions of soft tissue (from MRI) and bone (from CT) were combined to create 8 separate enhanced CT project files. Dissection of the corresponding cadavers anatomically validated the reconstructions created. Seven enhanced CT project files were then automatically fitted, separately in different regions, to obtain a single dataset of superimposed BP regions that incorporated anatomic variations. From this dataset, improved BP contouring guidelines were developed. These guidelines were then applied to the 7 original CT project files and also to 1 additional file, left out from the superimposing procedure. The percentage of BP inclusion was compared with the published guidelines. Results The anatomic validation procedure showed a high level of conformity for the BP regions examined between the 3-dimensional reconstructions generated and the dissected counterparts. Accurate and detailed BP contouring guidelines were developed, which provided corresponding guidance for each level in a clinical dataset. An average margin of 4.7 mm around the anatomically validated BP contour is sufficient to accommodate for anatomic variations. Using the new guidelines, 100% inclusion of the BP was achieved, compared with a mean inclusion of 37.75% when published guidelines were applied. Conclusion Improved guidelines for BP delineation were developed using combined MRI and CT imaging with validation by anatomic dissection.</description><subject>Aged</subject><subject>Brachial Plexus - anatomy & histology</subject><subject>Brachial Plexus - diagnostic imaging</subject><subject>Cadaver</subject><subject>COMPUTERIZED TOMOGRAPHY</subject><subject>Female</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Imaging, Three-Dimensional - methods</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical Illustration</subject><subject>NMR IMAGING</subject><subject>Patient Positioning - methods</subject><subject>PLANNING</subject><subject>Practice Guidelines as Topic - standards</subject><subject>Radiology</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>RADIOTHERAPY</subject><subject>Radiotherapy Planning, Computer-Assisted - methods</subject><subject>Radiotherapy, Intensity-Modulated - methods</subject><subject>RECOMMENDATIONS</subject><subject>THREE-DIMENSIONAL CALCULATIONS</subject><subject>Tomography, X-Ray Computed - methods</subject><issn>0360-3016</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks1u1DAUhSMEokPhDRCKxIZNBv_GzgZpGPFTqRUICurO8tg3jEPGHmwHMW-PQwoLNl15851zff25qp5itMYIty-HtRti2B3XBGG6RnKNELtXrbAUXUM5v7lfrRBtUUMLfFY9SmlACGEs2MPqjDBMZYe7VeU3vt54ncPBGT2Op_qrHp3VGWz9Omqzd3qsP47wa0r1Nvgcpuj8t_oK8j7Yug-xvvAZfHL5VF8FO41_kp-0dTq74OvrPUR9PJUK7X1JPq4e9HpM8OT2PK--vH1zvX3fXH54d7HdXDaGCZkbTVu-sz3nHDHLiURW250U0GKCDUI9Y4xT3WIhgIPpe0GEkIZSyi1gqRk9r54vvSFlp5JxGczeBO_BZEUIaUXHSaFeLNQxhh8TpKwOLhkYy2UhTEnhVoq2xUiyu1HGaNd1lM6tbEFNDClF6NUxuoOOJ4WRmtWpQS3q1KxOIamKuhJ7djth2h3A_gv9dVWAVwsA5eF-OojzXuANWBfntWxwd034v8CMzs_ev8MJ0lDk-iJFYZWIQurz_H3m34MpIl2LbuhvNGTAsw</recordid><startdate>20131115</startdate><enddate>20131115</enddate><creator>Van de Velde, Joris, MSc</creator><creator>Audenaert, Emmanuel, MD, PhD</creator><creator>Speleers, Bruno, MSc</creator><creator>Vercauteren, Tom, MSc</creator><creator>Mulliez, Thomas, MD</creator><creator>Vandemaele, Pieter, Ir</creator><creator>Achten, Eric, MD, PhD</creator><creator>Kerckaert, Ingrid, MD, PhD</creator><creator>D'Herde, Katharina, MD, PhD</creator><creator>De Neve, Wilfried, MD, PhD</creator><creator>Van Hoof, Tom, MSc, PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U7</scope><scope>C1K</scope><scope>OTOTI</scope></search><sort><creationdate>20131115</creationdate><title>An Anatomically Validated Brachial Plexus Contouring Method for Intensity Modulated Radiation Therapy Planning</title><author>Van de Velde, Joris, MSc ; Audenaert, Emmanuel, MD, PhD ; Speleers, Bruno, MSc ; Vercauteren, Tom, MSc ; Mulliez, Thomas, MD ; Vandemaele, Pieter, Ir ; Achten, Eric, MD, PhD ; Kerckaert, Ingrid, MD, PhD ; D'Herde, Katharina, MD, PhD ; De Neve, Wilfried, MD, PhD ; Van Hoof, Tom, MSc, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-a365bdf55504d5280dadb87e6121c00f44453a6177e5ecff72778c3335de18a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Brachial Plexus - anatomy & histology</topic><topic>Brachial Plexus - diagnostic imaging</topic><topic>Cadaver</topic><topic>COMPUTERIZED TOMOGRAPHY</topic><topic>Female</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Imaging, Three-Dimensional - methods</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medical Illustration</topic><topic>NMR IMAGING</topic><topic>Patient Positioning - methods</topic><topic>PLANNING</topic><topic>Practice Guidelines as Topic - standards</topic><topic>Radiology</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>RADIOTHERAPY</topic><topic>Radiotherapy Planning, Computer-Assisted - methods</topic><topic>Radiotherapy, Intensity-Modulated - methods</topic><topic>RECOMMENDATIONS</topic><topic>THREE-DIMENSIONAL CALCULATIONS</topic><topic>Tomography, X-Ray Computed - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Van de Velde, Joris, MSc</creatorcontrib><creatorcontrib>Audenaert, Emmanuel, MD, PhD</creatorcontrib><creatorcontrib>Speleers, Bruno, MSc</creatorcontrib><creatorcontrib>Vercauteren, Tom, MSc</creatorcontrib><creatorcontrib>Mulliez, Thomas, MD</creatorcontrib><creatorcontrib>Vandemaele, Pieter, Ir</creatorcontrib><creatorcontrib>Achten, Eric, MD, PhD</creatorcontrib><creatorcontrib>Kerckaert, Ingrid, MD, PhD</creatorcontrib><creatorcontrib>D'Herde, Katharina, MD, PhD</creatorcontrib><creatorcontrib>De Neve, Wilfried, MD, PhD</creatorcontrib><creatorcontrib>Van Hoof, Tom, MSc, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>OSTI.GOV</collection><jtitle>International journal of radiation oncology, biology, physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Van de Velde, Joris, MSc</au><au>Audenaert, Emmanuel, MD, PhD</au><au>Speleers, Bruno, MSc</au><au>Vercauteren, Tom, MSc</au><au>Mulliez, Thomas, MD</au><au>Vandemaele, Pieter, Ir</au><au>Achten, Eric, MD, PhD</au><au>Kerckaert, Ingrid, MD, PhD</au><au>D'Herde, Katharina, MD, PhD</au><au>De Neve, Wilfried, MD, PhD</au><au>Van Hoof, Tom, MSc, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An Anatomically Validated Brachial Plexus Contouring Method for Intensity Modulated Radiation Therapy Planning</atitle><jtitle>International journal of radiation oncology, biology, physics</jtitle><addtitle>Int J Radiat Oncol Biol Phys</addtitle><date>2013-11-15</date><risdate>2013</risdate><volume>87</volume><issue>4</issue><spage>802</spage><epage>808</epage><pages>802-808</pages><issn>0360-3016</issn><eissn>1879-355X</eissn><abstract>Purpose To develop contouring guidelines for the brachial plexus (BP) using anatomically validated cadaver datasets. Magnetic resonance imaging (MRI) and computed tomography (CT) were used to obtain detailed visualizations of the BP region, with the goal of achieving maximal inclusion of the actual BP in a small contoured volume while also accommodating for anatomic variations. Methods and Materials CT and MRI were obtained for 8 cadavers positioned for intensity modulated radiation therapy. 3-dimensional reconstructions of soft tissue (from MRI) and bone (from CT) were combined to create 8 separate enhanced CT project files. Dissection of the corresponding cadavers anatomically validated the reconstructions created. Seven enhanced CT project files were then automatically fitted, separately in different regions, to obtain a single dataset of superimposed BP regions that incorporated anatomic variations. From this dataset, improved BP contouring guidelines were developed. These guidelines were then applied to the 7 original CT project files and also to 1 additional file, left out from the superimposing procedure. The percentage of BP inclusion was compared with the published guidelines. Results The anatomic validation procedure showed a high level of conformity for the BP regions examined between the 3-dimensional reconstructions generated and the dissected counterparts. Accurate and detailed BP contouring guidelines were developed, which provided corresponding guidance for each level in a clinical dataset. An average margin of 4.7 mm around the anatomically validated BP contour is sufficient to accommodate for anatomic variations. Using the new guidelines, 100% inclusion of the BP was achieved, compared with a mean inclusion of 37.75% when published guidelines were applied. Conclusion Improved guidelines for BP delineation were developed using combined MRI and CT imaging with validation by anatomic dissection.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>24138919</pmid><doi>10.1016/j.ijrobp.2013.08.004</doi><tpages>7</tpages></addata></record> |
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| subjects | Aged Brachial Plexus - anatomy & histology Brachial Plexus - diagnostic imaging Cadaver COMPUTERIZED TOMOGRAPHY Female Hematology, Oncology and Palliative Medicine Humans Imaging, Three-Dimensional - methods Magnetic Resonance Imaging - methods Male Medical Illustration NMR IMAGING Patient Positioning - methods PLANNING Practice Guidelines as Topic - standards Radiology RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY Radiotherapy Planning, Computer-Assisted - methods Radiotherapy, Intensity-Modulated - methods RECOMMENDATIONS THREE-DIMENSIONAL CALCULATIONS Tomography, X-Ray Computed - methods |
| title | An Anatomically Validated Brachial Plexus Contouring Method for Intensity Modulated Radiation Therapy Planning |
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