Antitumour agents as inhibitors of tryptophan 2,3-dioxygenase

•∼2800 National Cancer Institute USA compounds have been screened as potential inhibitors of TDO and/or IDO.•Seven compounds with anti-tumour properties have been identified as potent inhibitors.•NSC 36398 (taxifolin, dihydroquercetin) is selective for TDO with a Ki of 16M.•This may help further our...

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Veröffentlicht in:	Biochemical and biophysical research communications 2014-01, Vol.443 (1), p.28-31
Hauptverfasser:	Pantouris, Georgios, Mowat, Christopher G.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Antineoplastic Agents - pharmacology Cancer Catechols - pharmacology Cell Line, Tumor Chromones - pharmacology ENZYMES Humans IN VITRO INHIBITION KYNURENINE Kynurenine pathway NEOPLASMS Quercetin - analogs & derivatives Quercetin - pharmacology THERAPEUTIC USES TRYPTOPHAN Tryptophan 2,3-dioxygenase Tryptophan Oxygenase - antagonists & inhibitors
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