HMGB1 induces an inflammatory response in endothelial cells via the RAGE-dependent endoplasmic reticulum stress pathway

•Mechanisms of inflammatory response induced by HMGB1 are incompletely understood.•We found that endoplasmic reticulum stress mediate the inflammatory response induced by HMGB1.•RAGE-mediated ERS pathways are involved in those processes.•We reported a new mechanism for HMGB1 induced inflammatory res...

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Veröffentlicht in:	Biochemical and biophysical research communications 2013-09, Vol.438 (4), p.732-738
Hauptverfasser:	Luo, Ying, Li, Shu-Jun, Yang, Jian, Qiu, Yuan-Zhen, Chen, Fang-Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ANTIBODIES ARTERIOSCLEROSIS ENDOPLASMIC RETICULUM Endoplasmic Reticulum Stress Endothelial Cells - immunology HMGB1 HMGB1 Protein - immunology Human Umbilical Vein Endothelial Cells Humans ICAM-1 INFLAMMATION Intercellular Adhesion Molecule-1 - immunology IRE1 P-selectin P-Selectin - immunology PERK PROTEINS RAGE Receptor for Advanced Glycation End Products Receptors, Immunologic - immunology Signal Transduction
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