Celastrol inhibits TGF-β1-induced epithelial–mesenchymal transition by inhibiting Snail and regulating E-cadherin expression

•We investigated the effects of celastrol on TGF-β1-induced EMT in epithelial cells.•Celastrol regulates TGF-β1-induced morphological changes and E-cadherin expression.•Celastrol inhibits TGF-β1-induced Snail expression.•Celastrol strongly suppresses TGF-β1-induced invasion in MDCK and A549 cells. T...

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Veröffentlicht in:	Biochemical and biophysical research communications 2013-08, Vol.437 (4), p.550-556
Hauptverfasser:	Kang, Hyereen, Lee, Minjae, Jang, Sung-Wuk
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Animals Antineoplastic Agents - pharmacology Cadherins - metabolism Celastrol Cell Line, Tumor Cell Movement Cell Proliferation Cell Survival DOGS E-cadherin EMT Epithelial-Mesenchymal Transition Gene Expression Profiling Gene Expression Regulation GLIOMAS GROWTH FACTORS Humans Invasion KIDNEYS LEUKEMIA Lung Neoplasms - metabolism LUNGS Madin Darby Canine Kidney Cells MAMMARY GLANDS METASTASES MORPHOLOGICAL CHANGES Neoplasm Invasiveness PROSTATE Snail Snail Family Transcription Factors SNAILS Transcription Factors - metabolism Transforming Growth Factor beta1 - pharmacology Triterpenes - pharmacology TUMOR CELLS
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