Cellular interactions via conditioned media induce in vivo nephron generation from tubular epithelial cells or mesenchymal stem cells

•We have attempted in vivo nephron generation using conditioned media.•Vascular and tubular cells do cross-talks on cell proliferation and tubular changes.•Tubular cells suppress these changes in mesenchymal stem cells.•Tubular cells differentiate mesenchymal stem cells into tubular cells.•Nephrons...

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Veröffentlicht in:	Biochemical and biophysical research communications 2013-06, Vol.435 (3), p.327-333
Hauptverfasser:	Machiguchi, Toshihiko, Nakamura, Tatsuo
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ANIMAL TISSUES Animals BUDS Cell Communication - physiology Cell Differentiation CELL PROLIFERATION Cells, Cultured Conditioned medium Cross-talk Culture Media, Conditioned Cytokines - metabolism Dogs Endothelial Cells - cytology Endothelial Cells - physiology Epithelial Cells - cytology Epithelial Cells - physiology Glomerulogenesis Humans IN VIVO Kidney Tubules - cytology Kidney Tubules - physiology KIDNEYS Mesenchymal stem cell Mesenchymal Stem Cell Transplantation Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - physiology Mice MORPHOLOGICAL CHANGES Nephron generation Nephrons - cytology Nephrons - physiology Rats Rats, Hairless Regeneration - physiology STEM CELLS Transplantation, Heterologous Tubular epithelial cell
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