Clinical Application of In-Room Positron Emission Tomography for In Vivo Treatment Monitoring in Proton Radiation Therapy
Purpose The purpose of this study is to evaluate the potential of using in-room positron emission tomography (PET) for treatment verification in proton therapy and for deriving suitable PET scan times. Methods and Materials Nine patients undergoing passive scattering proton therapy underwent scannin...
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| Veröffentlicht in: | International journal of radiation oncology, biology, physics biology, physics, 2013-05, Vol.86 (1), p.183-189 |
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| creator | Min, Chul Hee, PhD Zhu, Xuping, PhD Winey, Brian A., PhD Grogg, Kira, PhD Testa, Mauro, PhD El Fakhri, Georges, PhD Bortfeld, Thomas R., PhD Paganetti, Harald, PhD Shih, Helen A., MD |
| description | Purpose The purpose of this study is to evaluate the potential of using in-room positron emission tomography (PET) for treatment verification in proton therapy and for deriving suitable PET scan times. Methods and Materials Nine patients undergoing passive scattering proton therapy underwent scanning immediately after treatment with an in-room PET scanner. The scanner was positioned next to the treatment head after treatment. The Monte Carlo (MC) method was used to reproduce PET activities for each patient. To assess the proton beam range uncertainty, we designed a novel concept in which the measured PET activity surface distal to the target at the end of range was compared with MC predictions. The repositioning of patients for the PET scan took, on average, approximately 2 minutes. The PET images were reconstructed considering varying scan times to test the scan time dependency of the method. Results The measured PET images show overall good spatial correlations with MC predictions. Some discrepancies could be attributed to uncertainties in the local elemental composition and biological washout. For 8 patients treated with a single field, the average range differences between PET measurements and computed tomography (CT) image-based MC results were |
| doi_str_mv | 10.1016/j.ijrobp.2012.12.010 |
| format | Article |
| fullrecord | <record><control><sourceid>elsevier_osti_</sourceid><recordid>TN_cdi_osti_scitechconnect_22224462</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0360301612039065</els_id><sourcerecordid>1_s2_0_S0360301612039065</sourcerecordid><originalsourceid>FETCH-LOGICAL-c491t-a502db144d43a41a88f081a3354783b7540a63951e037b244364f3f6325fae3f3</originalsourceid><addsrcrecordid>eNqFUV1rHCEUldLSbJP-g1KEPs_Wq87XSyEsSRpIaUi2pW_iOJp1uqODmsD8-zhM2oe-VC540XOO13MQ-gBkCwSqz8PWDsF305YSoNtcBMgrtIGmbgtWlr9eow1hFSlYBp-gdzEOhBCAmr9FJ5SxFhqoN2jeHa2zSh7x-TQdc5Osd9gbfO2KO-9HfOujTSGfXYw2xuVy70f_EOR0mLHxIQPxT_vk8T5omUbtEv7mnU0-WPeArcO3wafMupO9XcX3B53Z8xl6Y-Qx6vcv-yn6cXmx330tbr5fXe_ObwrFW0iFLAntO-C850xykE1jSAOSsZLXDevqkhNZsbYETVjdUc5ZxQ0zFaOlkZoZdoo-rbo-Jiuiskmrg_LOaZUEzYvzimYUX1Eq-BiDNmIKdpRhFkDE4rcYxOq3WPwWubLfmfZxpU2P3aj7v6Q_BmfAlxWg8xefrA7LBNop3duwDNB7-78X_hVQL4n91rOOg38MLtsnQMRMEPdL5kvkQAlrSVWyZ4jsp-U</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Clinical Application of In-Room Positron Emission Tomography for In Vivo Treatment Monitoring in Proton Radiation Therapy</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Min, Chul Hee, PhD ; Zhu, Xuping, PhD ; Winey, Brian A., PhD ; Grogg, Kira, PhD ; Testa, Mauro, PhD ; El Fakhri, Georges, PhD ; Bortfeld, Thomas R., PhD ; Paganetti, Harald, PhD ; Shih, Helen A., MD</creator><creatorcontrib>Min, Chul Hee, PhD ; Zhu, Xuping, PhD ; Winey, Brian A., PhD ; Grogg, Kira, PhD ; Testa, Mauro, PhD ; El Fakhri, Georges, PhD ; Bortfeld, Thomas R., PhD ; Paganetti, Harald, PhD ; Shih, Helen A., MD</creatorcontrib><description>Purpose The purpose of this study is to evaluate the potential of using in-room positron emission tomography (PET) for treatment verification in proton therapy and for deriving suitable PET scan times. Methods and Materials Nine patients undergoing passive scattering proton therapy underwent scanning immediately after treatment with an in-room PET scanner. The scanner was positioned next to the treatment head after treatment. The Monte Carlo (MC) method was used to reproduce PET activities for each patient. To assess the proton beam range uncertainty, we designed a novel concept in which the measured PET activity surface distal to the target at the end of range was compared with MC predictions. The repositioning of patients for the PET scan took, on average, approximately 2 minutes. The PET images were reconstructed considering varying scan times to test the scan time dependency of the method. Results The measured PET images show overall good spatial correlations with MC predictions. Some discrepancies could be attributed to uncertainties in the local elemental composition and biological washout. For 8 patients treated with a single field, the average range differences between PET measurements and computed tomography (CT) image-based MC results were <5 mm (<3 mm for 6 of 8 patients) and root-mean-square deviations were 4 to 11 mm with PET-CT image co-registration errors of approximately 2 mm. Our results also show that a short-length PET scan of 5 minutes can yield results similar to those of a 20-minute PET scan. Conclusions Our first clinical trials in 9 patients using an in-room PET system demonstrated its potential for in vivo treatment monitoring in proton therapy. For a quantitative range prediction with arbitrary shape of target volume, we suggest using the distal PET activity surface.</description><identifier>ISSN: 0360-3016</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/j.ijrobp.2012.12.010</identifier><identifier>PMID: 23391817</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; CLINICAL TRIALS ; COMPUTERIZED TOMOGRAPHY ; Female ; Head and Neck Neoplasms - diagnostic imaging ; Head and Neck Neoplasms - radiotherapy ; Hematology, Oncology and Palliative Medicine ; Humans ; IMAGE PROCESSING ; Image Processing, Computer-Assisted - methods ; IN VIVO ; Male ; Middle Aged ; MONTE CARLO METHOD ; Patient Positioning - methods ; PATIENTS ; POSITRON COMPUTED TOMOGRAPHY ; Positron-Emission Tomography - instrumentation ; Positron-Emission Tomography - methods ; PROTON BEAMS ; Proton Therapy - methods ; Radiology ; RADIOLOGY AND NUCLEAR MEDICINE ; RADIOTHERAPY ; Radiotherapy Dosage ; Scattering, Radiation ; Time Factors ; VERIFICATION ; Young Adult</subject><ispartof>International journal of radiation oncology, biology, physics, 2013-05, Vol.86 (1), p.183-189</ispartof><rights>Elsevier Inc.</rights><rights>2013 Elsevier Inc.</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-a502db144d43a41a88f081a3354783b7540a63951e037b244364f3f6325fae3f3</citedby><cites>FETCH-LOGICAL-c491t-a502db144d43a41a88f081a3354783b7540a63951e037b244364f3f6325fae3f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijrobp.2012.12.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,315,781,785,886,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23391817$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/22224462$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Min, Chul Hee, PhD</creatorcontrib><creatorcontrib>Zhu, Xuping, PhD</creatorcontrib><creatorcontrib>Winey, Brian A., PhD</creatorcontrib><creatorcontrib>Grogg, Kira, PhD</creatorcontrib><creatorcontrib>Testa, Mauro, PhD</creatorcontrib><creatorcontrib>El Fakhri, Georges, PhD</creatorcontrib><creatorcontrib>Bortfeld, Thomas R., PhD</creatorcontrib><creatorcontrib>Paganetti, Harald, PhD</creatorcontrib><creatorcontrib>Shih, Helen A., MD</creatorcontrib><title>Clinical Application of In-Room Positron Emission Tomography for In Vivo Treatment Monitoring in Proton Radiation Therapy</title><title>International journal of radiation oncology, biology, physics</title><addtitle>Int J Radiat Oncol Biol Phys</addtitle><description>Purpose The purpose of this study is to evaluate the potential of using in-room positron emission tomography (PET) for treatment verification in proton therapy and for deriving suitable PET scan times. Methods and Materials Nine patients undergoing passive scattering proton therapy underwent scanning immediately after treatment with an in-room PET scanner. The scanner was positioned next to the treatment head after treatment. The Monte Carlo (MC) method was used to reproduce PET activities for each patient. To assess the proton beam range uncertainty, we designed a novel concept in which the measured PET activity surface distal to the target at the end of range was compared with MC predictions. The repositioning of patients for the PET scan took, on average, approximately 2 minutes. The PET images were reconstructed considering varying scan times to test the scan time dependency of the method. Results The measured PET images show overall good spatial correlations with MC predictions. Some discrepancies could be attributed to uncertainties in the local elemental composition and biological washout. For 8 patients treated with a single field, the average range differences between PET measurements and computed tomography (CT) image-based MC results were <5 mm (<3 mm for 6 of 8 patients) and root-mean-square deviations were 4 to 11 mm with PET-CT image co-registration errors of approximately 2 mm. Our results also show that a short-length PET scan of 5 minutes can yield results similar to those of a 20-minute PET scan. Conclusions Our first clinical trials in 9 patients using an in-room PET system demonstrated its potential for in vivo treatment monitoring in proton therapy. For a quantitative range prediction with arbitrary shape of target volume, we suggest using the distal PET activity surface.</description><subject>Adult</subject><subject>CLINICAL TRIALS</subject><subject>COMPUTERIZED TOMOGRAPHY</subject><subject>Female</subject><subject>Head and Neck Neoplasms - diagnostic imaging</subject><subject>Head and Neck Neoplasms - radiotherapy</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>IMAGE PROCESSING</subject><subject>Image Processing, Computer-Assisted - methods</subject><subject>IN VIVO</subject><subject>Male</subject><subject>Middle Aged</subject><subject>MONTE CARLO METHOD</subject><subject>Patient Positioning - methods</subject><subject>PATIENTS</subject><subject>POSITRON COMPUTED TOMOGRAPHY</subject><subject>Positron-Emission Tomography - instrumentation</subject><subject>Positron-Emission Tomography - methods</subject><subject>PROTON BEAMS</subject><subject>Proton Therapy - methods</subject><subject>Radiology</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>RADIOTHERAPY</subject><subject>Radiotherapy Dosage</subject><subject>Scattering, Radiation</subject><subject>Time Factors</subject><subject>VERIFICATION</subject><subject>Young Adult</subject><issn>0360-3016</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUV1rHCEUldLSbJP-g1KEPs_Wq87XSyEsSRpIaUi2pW_iOJp1uqODmsD8-zhM2oe-VC540XOO13MQ-gBkCwSqz8PWDsF305YSoNtcBMgrtIGmbgtWlr9eow1hFSlYBp-gdzEOhBCAmr9FJ5SxFhqoN2jeHa2zSh7x-TQdc5Osd9gbfO2KO-9HfOujTSGfXYw2xuVy70f_EOR0mLHxIQPxT_vk8T5omUbtEv7mnU0-WPeArcO3wafMupO9XcX3B53Z8xl6Y-Qx6vcv-yn6cXmx330tbr5fXe_ObwrFW0iFLAntO-C850xykE1jSAOSsZLXDevqkhNZsbYETVjdUc5ZxQ0zFaOlkZoZdoo-rbo-Jiuiskmrg_LOaZUEzYvzimYUX1Eq-BiDNmIKdpRhFkDE4rcYxOq3WPwWubLfmfZxpU2P3aj7v6Q_BmfAlxWg8xefrA7LBNop3duwDNB7-78X_hVQL4n91rOOg38MLtsnQMRMEPdL5kvkQAlrSVWyZ4jsp-U</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>Min, Chul Hee, PhD</creator><creator>Zhu, Xuping, PhD</creator><creator>Winey, Brian A., PhD</creator><creator>Grogg, Kira, PhD</creator><creator>Testa, Mauro, PhD</creator><creator>El Fakhri, Georges, PhD</creator><creator>Bortfeld, Thomas R., PhD</creator><creator>Paganetti, Harald, PhD</creator><creator>Shih, Helen A., MD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope></search><sort><creationdate>20130501</creationdate><title>Clinical Application of In-Room Positron Emission Tomography for In Vivo Treatment Monitoring in Proton Radiation Therapy</title><author>Min, Chul Hee, PhD ; Zhu, Xuping, PhD ; Winey, Brian A., PhD ; Grogg, Kira, PhD ; Testa, Mauro, PhD ; El Fakhri, Georges, PhD ; Bortfeld, Thomas R., PhD ; Paganetti, Harald, PhD ; Shih, Helen A., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-a502db144d43a41a88f081a3354783b7540a63951e037b244364f3f6325fae3f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>CLINICAL TRIALS</topic><topic>COMPUTERIZED TOMOGRAPHY</topic><topic>Female</topic><topic>Head and Neck Neoplasms - diagnostic imaging</topic><topic>Head and Neck Neoplasms - radiotherapy</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>IMAGE PROCESSING</topic><topic>Image Processing, Computer-Assisted - methods</topic><topic>IN VIVO</topic><topic>Male</topic><topic>Middle Aged</topic><topic>MONTE CARLO METHOD</topic><topic>Patient Positioning - methods</topic><topic>PATIENTS</topic><topic>POSITRON COMPUTED TOMOGRAPHY</topic><topic>Positron-Emission Tomography - instrumentation</topic><topic>Positron-Emission Tomography - methods</topic><topic>PROTON BEAMS</topic><topic>Proton Therapy - methods</topic><topic>Radiology</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>RADIOTHERAPY</topic><topic>Radiotherapy Dosage</topic><topic>Scattering, Radiation</topic><topic>Time Factors</topic><topic>VERIFICATION</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Min, Chul Hee, PhD</creatorcontrib><creatorcontrib>Zhu, Xuping, PhD</creatorcontrib><creatorcontrib>Winey, Brian A., PhD</creatorcontrib><creatorcontrib>Grogg, Kira, PhD</creatorcontrib><creatorcontrib>Testa, Mauro, PhD</creatorcontrib><creatorcontrib>El Fakhri, Georges, PhD</creatorcontrib><creatorcontrib>Bortfeld, Thomas R., PhD</creatorcontrib><creatorcontrib>Paganetti, Harald, PhD</creatorcontrib><creatorcontrib>Shih, Helen A., MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>International journal of radiation oncology, biology, physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Min, Chul Hee, PhD</au><au>Zhu, Xuping, PhD</au><au>Winey, Brian A., PhD</au><au>Grogg, Kira, PhD</au><au>Testa, Mauro, PhD</au><au>El Fakhri, Georges, PhD</au><au>Bortfeld, Thomas R., PhD</au><au>Paganetti, Harald, PhD</au><au>Shih, Helen A., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Application of In-Room Positron Emission Tomography for In Vivo Treatment Monitoring in Proton Radiation Therapy</atitle><jtitle>International journal of radiation oncology, biology, physics</jtitle><addtitle>Int J Radiat Oncol Biol Phys</addtitle><date>2013-05-01</date><risdate>2013</risdate><volume>86</volume><issue>1</issue><spage>183</spage><epage>189</epage><pages>183-189</pages><issn>0360-3016</issn><eissn>1879-355X</eissn><abstract>Purpose The purpose of this study is to evaluate the potential of using in-room positron emission tomography (PET) for treatment verification in proton therapy and for deriving suitable PET scan times. Methods and Materials Nine patients undergoing passive scattering proton therapy underwent scanning immediately after treatment with an in-room PET scanner. The scanner was positioned next to the treatment head after treatment. The Monte Carlo (MC) method was used to reproduce PET activities for each patient. To assess the proton beam range uncertainty, we designed a novel concept in which the measured PET activity surface distal to the target at the end of range was compared with MC predictions. The repositioning of patients for the PET scan took, on average, approximately 2 minutes. The PET images were reconstructed considering varying scan times to test the scan time dependency of the method. Results The measured PET images show overall good spatial correlations with MC predictions. Some discrepancies could be attributed to uncertainties in the local elemental composition and biological washout. For 8 patients treated with a single field, the average range differences between PET measurements and computed tomography (CT) image-based MC results were <5 mm (<3 mm for 6 of 8 patients) and root-mean-square deviations were 4 to 11 mm with PET-CT image co-registration errors of approximately 2 mm. Our results also show that a short-length PET scan of 5 minutes can yield results similar to those of a 20-minute PET scan. Conclusions Our first clinical trials in 9 patients using an in-room PET system demonstrated its potential for in vivo treatment monitoring in proton therapy. For a quantitative range prediction with arbitrary shape of target volume, we suggest using the distal PET activity surface.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23391817</pmid><doi>10.1016/j.ijrobp.2012.12.010</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0360-3016 |
| ispartof | International journal of radiation oncology, biology, physics, 2013-05, Vol.86 (1), p.183-189 |
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| subjects | Adult CLINICAL TRIALS COMPUTERIZED TOMOGRAPHY Female Head and Neck Neoplasms - diagnostic imaging Head and Neck Neoplasms - radiotherapy Hematology, Oncology and Palliative Medicine Humans IMAGE PROCESSING Image Processing, Computer-Assisted - methods IN VIVO Male Middle Aged MONTE CARLO METHOD Patient Positioning - methods PATIENTS POSITRON COMPUTED TOMOGRAPHY Positron-Emission Tomography - instrumentation Positron-Emission Tomography - methods PROTON BEAMS Proton Therapy - methods Radiology RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY Radiotherapy Dosage Scattering, Radiation Time Factors VERIFICATION Young Adult |
| title | Clinical Application of In-Room Positron Emission Tomography for In Vivo Treatment Monitoring in Proton Radiation Therapy |
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