Dose to the Developing Dentition During Therapeutic Irradiation: Organ at Risk Determination and Clinical Implications
Purpose Irradiation of pediatric facial structures can cause severe impairment of permanent teeth later in life. We therefore focused on primary and permanent teeth as organs at risk, investigating the ability to identify individual teeth in children and infants and to correlate dose distributions w...
Gespeichert in:
| Veröffentlicht in: | International journal of radiation oncology, biology, physics biology, physics, 2013-05, Vol.86 (1), p.108-113 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 113 |
|---|---|
| container_issue | 1 |
| container_start_page | 108 |
| container_title | International journal of radiation oncology, biology, physics |
| container_volume | 86 |
| creator | Thompson, Reid F., MD, PhD Schneider, Ralf A., MD Albertini, Francesca, PhD Lomax, Antony J., PhD Ares, Carmen, MD Goitein, Gudrun, MD Hug, Eugen B., MD |
| description | Purpose Irradiation of pediatric facial structures can cause severe impairment of permanent teeth later in life. We therefore focused on primary and permanent teeth as organs at risk, investigating the ability to identify individual teeth in children and infants and to correlate dose distributions with subsequent dental toxicity. Methods and Materials We retrospectively reviewed 14 pediatric patients who received a maximum dose >20 Gy(relative biological effectiveness, RBE) to 1 or more primary or permanent teeth between 2003 and 2009. The patients (aged 1-16 years) received spot-scanning proton therapy with 46 to 66 Gy(RBE) in 23 to 33 daily fractions for a variety of tumors, including rhabdomyosarcoma (n=10), sarcoma (n=2), teratoma (n=1), and carcinoma (n=1). Individual teeth were contoured on axial slices from planning computed tomography (CT) scans. Dose-volume histogram data were retrospectively obtained from total calculated delivered treatments. Dental follow-up information was obtained from external care providers. Results All primary teeth and permanent incisors, canines, premolars, and first and second molars were identifiable on CT scans in all patients as early as 1 year of age. Dose-volume histogram analysis showed wide dose variability, with a median 37 Gy(RBE) per tooth dose range across all individuals, and a median 50 Gy(RBE) intraindividual dose range across all teeth. Dental follow-up revealed absence of significant toxicity in 7 of 10 patients but severe localized toxicity in teeth receiving >20 Gy(RBE) among 3 patients who were all treated at |
| doi_str_mv | 10.1016/j.ijrobp.2012.11.041 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_osti_</sourceid><recordid>TN_cdi_osti_scitechconnect_22224451</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0360301612038394</els_id><sourcerecordid>23332385</sourcerecordid><originalsourceid>FETCH-LOGICAL-c445t-cad50a19162f7236e32ffb138815fb57c013ee51e31e2b5a45af897b36a88f1d3</originalsourceid><addsrcrecordid>eNqFkVGL1DAQx4Mo3nr6DUQCPreXSZpu1wdBdtVbODjQE3wLaTq9Ta-blCS7cN_e1J4--GJeMmT-_5nJbwh5C6wEBvXVUNoh-HYqOQNeApSsgmdkBc16Uwgpfz4nKyZqVogsviCvYhwYYwDr6iW54EIILhq5Iuedj0iTp-mAdIdnHP1k3X0OXbLJekd3pzA_3B0w6AlPyRq6D0F3Vs_pD_Q23GtHdaLfbHzIvoThaN3vJNWuo9vROmv0SPfHaczBnIivyYtejxHfPN2X5MeXz3fb6-Lm9ut---mmMFUlU2F0J5mGDdS8X3NRo-B934JoGpB9K9eGgUCUgAKQt1JXUvfNZt2KWjdND524JO-Xuj4mq6KxCc3BeOfQJMXzyW0gq6pFZYKPMWCvpmCPOjwqYGqGrQa1wFYzbAWgMuxse7fYplN7xO6v6Q_dLPi4CDB_8WwxzBOgM9jZMA_Qefu_Dv8WME80H_AR4-BPwWV8ClTkiqnv88LnfQNnohGbSvwCbdyn4A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Dose to the Developing Dentition During Therapeutic Irradiation: Organ at Risk Determination and Clinical Implications</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Thompson, Reid F., MD, PhD ; Schneider, Ralf A., MD ; Albertini, Francesca, PhD ; Lomax, Antony J., PhD ; Ares, Carmen, MD ; Goitein, Gudrun, MD ; Hug, Eugen B., MD</creator><creatorcontrib>Thompson, Reid F., MD, PhD ; Schneider, Ralf A., MD ; Albertini, Francesca, PhD ; Lomax, Antony J., PhD ; Ares, Carmen, MD ; Goitein, Gudrun, MD ; Hug, Eugen B., MD</creatorcontrib><description>Purpose Irradiation of pediatric facial structures can cause severe impairment of permanent teeth later in life. We therefore focused on primary and permanent teeth as organs at risk, investigating the ability to identify individual teeth in children and infants and to correlate dose distributions with subsequent dental toxicity. Methods and Materials We retrospectively reviewed 14 pediatric patients who received a maximum dose >20 Gy(relative biological effectiveness, RBE) to 1 or more primary or permanent teeth between 2003 and 2009. The patients (aged 1-16 years) received spot-scanning proton therapy with 46 to 66 Gy(RBE) in 23 to 33 daily fractions for a variety of tumors, including rhabdomyosarcoma (n=10), sarcoma (n=2), teratoma (n=1), and carcinoma (n=1). Individual teeth were contoured on axial slices from planning computed tomography (CT) scans. Dose-volume histogram data were retrospectively obtained from total calculated delivered treatments. Dental follow-up information was obtained from external care providers. Results All primary teeth and permanent incisors, canines, premolars, and first and second molars were identifiable on CT scans in all patients as early as 1 year of age. Dose-volume histogram analysis showed wide dose variability, with a median 37 Gy(RBE) per tooth dose range across all individuals, and a median 50 Gy(RBE) intraindividual dose range across all teeth. Dental follow-up revealed absence of significant toxicity in 7 of 10 patients but severe localized toxicity in teeth receiving >20 Gy(RBE) among 3 patients who were all treated at <4 years of age. Conclusions CT-based assessment of dose distribution to individual teeth is feasible, although delayed calcification may complicate tooth identification in the youngest patients. Patterns of dental dose exposure vary markedly within and among patients, corresponding to rapid dose falloff with protons. Severe localized dental toxicity was observed in a few patients receiving the largest doses of radiation at the youngest ages; however, multiple factors including concurrent chemotherapy confounded the dose-effect relationship. Further studies with larger cohorts and appropriate controls will be required.</description><identifier>ISSN: 0360-3016</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/j.ijrobp.2012.11.041</identifier><identifier>PMID: 23332385</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Antineoplastic Agents - adverse effects ; Carcinoma - radiotherapy ; CARCINOMAS ; CHEMOTHERAPY ; Child ; Child, Preschool ; COMPUTERIZED TOMOGRAPHY ; Dentition, Permanent ; DOGS ; Feasibility Studies ; Female ; Follow-Up Studies ; HEALTH HAZARDS ; Hematology, Oncology and Palliative Medicine ; Humans ; IMAGE PROCESSING ; Imaging, Three-Dimensional - methods ; Infant ; INFANTS ; IRRADIATION ; Male ; Neoplasms - drug therapy ; Neoplasms - radiotherapy ; ORGANS ; Organs at Risk - diagnostic imaging ; Organs at Risk - radiation effects ; PATIENTS ; PEDIATRICS ; Proton Therapy - adverse effects ; Proton Therapy - methods ; RADIATION DOSE DISTRIBUTIONS ; RADIATION DOSES ; Radiation Injuries - complications ; Radiology ; RADIOLOGY AND NUCLEAR MEDICINE ; Radiotherapy Dosage ; RBE ; Relative Biological Effectiveness ; Retrospective Studies ; REVIEWS ; Rhabdomyosarcoma - radiotherapy ; Sarcoma - radiotherapy ; SARCOMAS ; TEETH ; Teratoma - radiotherapy ; Tomography, X-Ray Computed ; Tooth - diagnostic imaging ; Tooth - radiation effects ; Tooth Germ - radiation effects ; Tooth, Deciduous ; TOXICITY</subject><ispartof>International journal of radiation oncology, biology, physics, 2013-05, Vol.86 (1), p.108-113</ispartof><rights>Elsevier Inc.</rights><rights>2013 Elsevier Inc.</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-cad50a19162f7236e32ffb138815fb57c013ee51e31e2b5a45af897b36a88f1d3</citedby><cites>FETCH-LOGICAL-c445t-cad50a19162f7236e32ffb138815fb57c013ee51e31e2b5a45af897b36a88f1d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0360301612038394$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23332385$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/22224451$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Thompson, Reid F., MD, PhD</creatorcontrib><creatorcontrib>Schneider, Ralf A., MD</creatorcontrib><creatorcontrib>Albertini, Francesca, PhD</creatorcontrib><creatorcontrib>Lomax, Antony J., PhD</creatorcontrib><creatorcontrib>Ares, Carmen, MD</creatorcontrib><creatorcontrib>Goitein, Gudrun, MD</creatorcontrib><creatorcontrib>Hug, Eugen B., MD</creatorcontrib><title>Dose to the Developing Dentition During Therapeutic Irradiation: Organ at Risk Determination and Clinical Implications</title><title>International journal of radiation oncology, biology, physics</title><addtitle>Int J Radiat Oncol Biol Phys</addtitle><description>Purpose Irradiation of pediatric facial structures can cause severe impairment of permanent teeth later in life. We therefore focused on primary and permanent teeth as organs at risk, investigating the ability to identify individual teeth in children and infants and to correlate dose distributions with subsequent dental toxicity. Methods and Materials We retrospectively reviewed 14 pediatric patients who received a maximum dose >20 Gy(relative biological effectiveness, RBE) to 1 or more primary or permanent teeth between 2003 and 2009. The patients (aged 1-16 years) received spot-scanning proton therapy with 46 to 66 Gy(RBE) in 23 to 33 daily fractions for a variety of tumors, including rhabdomyosarcoma (n=10), sarcoma (n=2), teratoma (n=1), and carcinoma (n=1). Individual teeth were contoured on axial slices from planning computed tomography (CT) scans. Dose-volume histogram data were retrospectively obtained from total calculated delivered treatments. Dental follow-up information was obtained from external care providers. Results All primary teeth and permanent incisors, canines, premolars, and first and second molars were identifiable on CT scans in all patients as early as 1 year of age. Dose-volume histogram analysis showed wide dose variability, with a median 37 Gy(RBE) per tooth dose range across all individuals, and a median 50 Gy(RBE) intraindividual dose range across all teeth. Dental follow-up revealed absence of significant toxicity in 7 of 10 patients but severe localized toxicity in teeth receiving >20 Gy(RBE) among 3 patients who were all treated at <4 years of age. Conclusions CT-based assessment of dose distribution to individual teeth is feasible, although delayed calcification may complicate tooth identification in the youngest patients. Patterns of dental dose exposure vary markedly within and among patients, corresponding to rapid dose falloff with protons. Severe localized dental toxicity was observed in a few patients receiving the largest doses of radiation at the youngest ages; however, multiple factors including concurrent chemotherapy confounded the dose-effect relationship. Further studies with larger cohorts and appropriate controls will be required.</description><subject>Adolescent</subject><subject>Antineoplastic Agents - adverse effects</subject><subject>Carcinoma - radiotherapy</subject><subject>CARCINOMAS</subject><subject>CHEMOTHERAPY</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>COMPUTERIZED TOMOGRAPHY</subject><subject>Dentition, Permanent</subject><subject>DOGS</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>HEALTH HAZARDS</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>IMAGE PROCESSING</subject><subject>Imaging, Three-Dimensional - methods</subject><subject>Infant</subject><subject>INFANTS</subject><subject>IRRADIATION</subject><subject>Male</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - radiotherapy</subject><subject>ORGANS</subject><subject>Organs at Risk - diagnostic imaging</subject><subject>Organs at Risk - radiation effects</subject><subject>PATIENTS</subject><subject>PEDIATRICS</subject><subject>Proton Therapy - adverse effects</subject><subject>Proton Therapy - methods</subject><subject>RADIATION DOSE DISTRIBUTIONS</subject><subject>RADIATION DOSES</subject><subject>Radiation Injuries - complications</subject><subject>Radiology</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>Radiotherapy Dosage</subject><subject>RBE</subject><subject>Relative Biological Effectiveness</subject><subject>Retrospective Studies</subject><subject>REVIEWS</subject><subject>Rhabdomyosarcoma - radiotherapy</subject><subject>Sarcoma - radiotherapy</subject><subject>SARCOMAS</subject><subject>TEETH</subject><subject>Teratoma - radiotherapy</subject><subject>Tomography, X-Ray Computed</subject><subject>Tooth - diagnostic imaging</subject><subject>Tooth - radiation effects</subject><subject>Tooth Germ - radiation effects</subject><subject>Tooth, Deciduous</subject><subject>TOXICITY</subject><issn>0360-3016</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVGL1DAQx4Mo3nr6DUQCPreXSZpu1wdBdtVbODjQE3wLaTq9Ta-blCS7cN_e1J4--GJeMmT-_5nJbwh5C6wEBvXVUNoh-HYqOQNeApSsgmdkBc16Uwgpfz4nKyZqVogsviCvYhwYYwDr6iW54EIILhq5Iuedj0iTp-mAdIdnHP1k3X0OXbLJekd3pzA_3B0w6AlPyRq6D0F3Vs_pD_Q23GtHdaLfbHzIvoThaN3vJNWuo9vROmv0SPfHaczBnIivyYtejxHfPN2X5MeXz3fb6-Lm9ut---mmMFUlU2F0J5mGDdS8X3NRo-B934JoGpB9K9eGgUCUgAKQt1JXUvfNZt2KWjdND524JO-Xuj4mq6KxCc3BeOfQJMXzyW0gq6pFZYKPMWCvpmCPOjwqYGqGrQa1wFYzbAWgMuxse7fYplN7xO6v6Q_dLPi4CDB_8WwxzBOgM9jZMA_Qefu_Dv8WME80H_AR4-BPwWV8ClTkiqnv88LnfQNnohGbSvwCbdyn4A</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>Thompson, Reid F., MD, PhD</creator><creator>Schneider, Ralf A., MD</creator><creator>Albertini, Francesca, PhD</creator><creator>Lomax, Antony J., PhD</creator><creator>Ares, Carmen, MD</creator><creator>Goitein, Gudrun, MD</creator><creator>Hug, Eugen B., MD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope></search><sort><creationdate>20130501</creationdate><title>Dose to the Developing Dentition During Therapeutic Irradiation: Organ at Risk Determination and Clinical Implications</title><author>Thompson, Reid F., MD, PhD ; Schneider, Ralf A., MD ; Albertini, Francesca, PhD ; Lomax, Antony J., PhD ; Ares, Carmen, MD ; Goitein, Gudrun, MD ; Hug, Eugen B., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-cad50a19162f7236e32ffb138815fb57c013ee51e31e2b5a45af897b36a88f1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Antineoplastic Agents - adverse effects</topic><topic>Carcinoma - radiotherapy</topic><topic>CARCINOMAS</topic><topic>CHEMOTHERAPY</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>COMPUTERIZED TOMOGRAPHY</topic><topic>Dentition, Permanent</topic><topic>DOGS</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>HEALTH HAZARDS</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>IMAGE PROCESSING</topic><topic>Imaging, Three-Dimensional - methods</topic><topic>Infant</topic><topic>INFANTS</topic><topic>IRRADIATION</topic><topic>Male</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - radiotherapy</topic><topic>ORGANS</topic><topic>Organs at Risk - diagnostic imaging</topic><topic>Organs at Risk - radiation effects</topic><topic>PATIENTS</topic><topic>PEDIATRICS</topic><topic>Proton Therapy - adverse effects</topic><topic>Proton Therapy - methods</topic><topic>RADIATION DOSE DISTRIBUTIONS</topic><topic>RADIATION DOSES</topic><topic>Radiation Injuries - complications</topic><topic>Radiology</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>Radiotherapy Dosage</topic><topic>RBE</topic><topic>Relative Biological Effectiveness</topic><topic>Retrospective Studies</topic><topic>REVIEWS</topic><topic>Rhabdomyosarcoma - radiotherapy</topic><topic>Sarcoma - radiotherapy</topic><topic>SARCOMAS</topic><topic>TEETH</topic><topic>Teratoma - radiotherapy</topic><topic>Tomography, X-Ray Computed</topic><topic>Tooth - diagnostic imaging</topic><topic>Tooth - radiation effects</topic><topic>Tooth Germ - radiation effects</topic><topic>Tooth, Deciduous</topic><topic>TOXICITY</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thompson, Reid F., MD, PhD</creatorcontrib><creatorcontrib>Schneider, Ralf A., MD</creatorcontrib><creatorcontrib>Albertini, Francesca, PhD</creatorcontrib><creatorcontrib>Lomax, Antony J., PhD</creatorcontrib><creatorcontrib>Ares, Carmen, MD</creatorcontrib><creatorcontrib>Goitein, Gudrun, MD</creatorcontrib><creatorcontrib>Hug, Eugen B., MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>International journal of radiation oncology, biology, physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thompson, Reid F., MD, PhD</au><au>Schneider, Ralf A., MD</au><au>Albertini, Francesca, PhD</au><au>Lomax, Antony J., PhD</au><au>Ares, Carmen, MD</au><au>Goitein, Gudrun, MD</au><au>Hug, Eugen B., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dose to the Developing Dentition During Therapeutic Irradiation: Organ at Risk Determination and Clinical Implications</atitle><jtitle>International journal of radiation oncology, biology, physics</jtitle><addtitle>Int J Radiat Oncol Biol Phys</addtitle><date>2013-05-01</date><risdate>2013</risdate><volume>86</volume><issue>1</issue><spage>108</spage><epage>113</epage><pages>108-113</pages><issn>0360-3016</issn><eissn>1879-355X</eissn><abstract>Purpose Irradiation of pediatric facial structures can cause severe impairment of permanent teeth later in life. We therefore focused on primary and permanent teeth as organs at risk, investigating the ability to identify individual teeth in children and infants and to correlate dose distributions with subsequent dental toxicity. Methods and Materials We retrospectively reviewed 14 pediatric patients who received a maximum dose >20 Gy(relative biological effectiveness, RBE) to 1 or more primary or permanent teeth between 2003 and 2009. The patients (aged 1-16 years) received spot-scanning proton therapy with 46 to 66 Gy(RBE) in 23 to 33 daily fractions for a variety of tumors, including rhabdomyosarcoma (n=10), sarcoma (n=2), teratoma (n=1), and carcinoma (n=1). Individual teeth were contoured on axial slices from planning computed tomography (CT) scans. Dose-volume histogram data were retrospectively obtained from total calculated delivered treatments. Dental follow-up information was obtained from external care providers. Results All primary teeth and permanent incisors, canines, premolars, and first and second molars were identifiable on CT scans in all patients as early as 1 year of age. Dose-volume histogram analysis showed wide dose variability, with a median 37 Gy(RBE) per tooth dose range across all individuals, and a median 50 Gy(RBE) intraindividual dose range across all teeth. Dental follow-up revealed absence of significant toxicity in 7 of 10 patients but severe localized toxicity in teeth receiving >20 Gy(RBE) among 3 patients who were all treated at <4 years of age. Conclusions CT-based assessment of dose distribution to individual teeth is feasible, although delayed calcification may complicate tooth identification in the youngest patients. Patterns of dental dose exposure vary markedly within and among patients, corresponding to rapid dose falloff with protons. Severe localized dental toxicity was observed in a few patients receiving the largest doses of radiation at the youngest ages; however, multiple factors including concurrent chemotherapy confounded the dose-effect relationship. Further studies with larger cohorts and appropriate controls will be required.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23332385</pmid><doi>10.1016/j.ijrobp.2012.11.041</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0360-3016 |
| ispartof | International journal of radiation oncology, biology, physics, 2013-05, Vol.86 (1), p.108-113 |
| issn | 0360-3016 1879-355X |
| language | eng |
| recordid | cdi_osti_scitechconnect_22224451 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adolescent Antineoplastic Agents - adverse effects Carcinoma - radiotherapy CARCINOMAS CHEMOTHERAPY Child Child, Preschool COMPUTERIZED TOMOGRAPHY Dentition, Permanent DOGS Feasibility Studies Female Follow-Up Studies HEALTH HAZARDS Hematology, Oncology and Palliative Medicine Humans IMAGE PROCESSING Imaging, Three-Dimensional - methods Infant INFANTS IRRADIATION Male Neoplasms - drug therapy Neoplasms - radiotherapy ORGANS Organs at Risk - diagnostic imaging Organs at Risk - radiation effects PATIENTS PEDIATRICS Proton Therapy - adverse effects Proton Therapy - methods RADIATION DOSE DISTRIBUTIONS RADIATION DOSES Radiation Injuries - complications Radiology RADIOLOGY AND NUCLEAR MEDICINE Radiotherapy Dosage RBE Relative Biological Effectiveness Retrospective Studies REVIEWS Rhabdomyosarcoma - radiotherapy Sarcoma - radiotherapy SARCOMAS TEETH Teratoma - radiotherapy Tomography, X-Ray Computed Tooth - diagnostic imaging Tooth - radiation effects Tooth Germ - radiation effects Tooth, Deciduous TOXICITY |
| title | Dose to the Developing Dentition During Therapeutic Irradiation: Organ at Risk Determination and Clinical Implications |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T19%3A26%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_osti_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dose%20to%20the%20Developing%20Dentition%20During%20Therapeutic%20Irradiation:%20Organ%20at%20Risk%20Determination%20and%20Clinical%20Implications&rft.jtitle=International%20journal%20of%20radiation%20oncology,%20biology,%20physics&rft.au=Thompson,%20Reid%20F.,%20MD,%20PhD&rft.date=2013-05-01&rft.volume=86&rft.issue=1&rft.spage=108&rft.epage=113&rft.pages=108-113&rft.issn=0360-3016&rft.eissn=1879-355X&rft_id=info:doi/10.1016/j.ijrobp.2012.11.041&rft_dat=%3Cpubmed_osti_%3E23332385%3C/pubmed_osti_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/23332385&rft_els_id=1_s2_0_S0360301612038394&rfr_iscdi=true |