Age and Comorbid Illness Are Associated With Late Rectal Toxicity Following Dose-Escalated Radiation Therapy for Prostate Cancer

Purpose To assess the impacts of patient age and comorbid illness on rectal toxicity following external beam radiation therapy (EBRT) for prostate cancer and to assess the Qualitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC) normal tissue complication probability (NTCP) model in thi...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2013-04, Vol.85 (5), p.1246-1253
Hauptverfasser:	Hamstra, Daniel A., MD, PhD, Stenmark, Matt H., MD, Ritter, Tim, PhD, Litzenberg, Dale, PhD, Jackson, William, BS, Johnson, Skyler, BS, Albrecht-Unger, Liesel, BS, Donaghy, Alex, BS, Phelps, Laura, BS, Blas, Kevin, MD, Halverson, Schuyler, BS, Marsh, Robin, CMD, Olson, Karin, PhD, Feng, Felix Y., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aged Aged, 80 and over ANIMAL TISSUES ANTICOAGULANTS Anticoagulants - administration & dosage Anticoagulants - adverse effects Comorbidity EXTERNAL BEAM RADIATION THERAPY HEALTH HAZARDS HEART FAILURE Heart Failure - epidemiology Hematology, Oncology and Palliative Medicine Humans Incidence Male Middle Aged Models, Statistical MULTIVARIATE ANALYSIS MYOCARDIAL INFARCTION Myocardial Infarction - epidemiology NEOPLASMS Organs at Risk - radiation effects PATIENTS PROSTATE Prostatic Neoplasms - epidemiology Prostatic Neoplasms - radiotherapy RADIATION DOSES Radiation Injuries - epidemiology Radiation Injuries - pathology Radiology RADIOLOGY AND NUCLEAR MEDICINE Radiotherapy Dosage Radiotherapy, Image-Guided Radiotherapy, Intensity-Modulated RECTUM Rectum - radiation effects Time Factors TOXICITY
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