AMP-activated protein kinase phosphorylates CtBP1 and down-regulates its activity

► AMPK phosphorylates CtBP1 on serine 158. ► AMPK-mediated phosphorylation of CtBP1 causes the ubiquitination and nuclear export of CtBP1. ► AMPK downregulates the CtBP1-mediated repression of Bax transcription. CtBP is a transcriptional repressor which plays a significant role in the regulation of...

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Veröffentlicht in:	Biochemical and biophysical research communications 2013-02, Vol.431 (1), p.8-13
Hauptverfasser:	Kim, Jae-Hwan, Choi, Soo-Youn, Kang, Byung-Hee, Lee, Soon-Min, Park, Hyung Soon, Kang, Gum-Yong, Bang, Joo Young, Cho, Eun-Jung, Youn, Hong-Duk
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Alcohol Oxidoreductases - genetics Alcohol Oxidoreductases - metabolism AMP AMP-Activated Protein Kinases - biosynthesis AMP-Activated Protein Kinases - metabolism AMPK APOPTOSIS Bax bcl-2-Associated X Protein - genetics CELL PROLIFERATION CtBP1 DISSOCIATION DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Enzyme Activation Gene Expression Regulation GENE REGULATION GLUCOSE HEK293 Cells Humans NEOPLASMS PHOSPHORYLATION PROMOTERS PROTEINS SERINE Serine - genetics Serine - metabolism TRANSCRIPTION Transcription, Genetic Ubiquitination
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