NecroX-7 prevents oxidative stress-induced cardiomyopathy by inhibition of NADPH oxidase activity in rats

Oxidative stress is one of the causes of cardiomyopathy. In the present study, NecroXs, novel class of mitochondrial ROS/RNS scavengers, were evaluated for cardioprotection in in vitro and in vivo model, and the putative mechanism of the cardioprotection of NecroX-7 was investigated by global gene e...

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Veröffentlicht in:	Toxicology and applied pharmacology 2012-08, Vol.263 (1), p.1-6
Hauptverfasser:	Park, Joonghoon, Park, Eok, Ahn, Bong-Hyun, Kim, Hyoung Jin, Park, Ji-hoon, Koo, Sun Young, Kwak, Hyo-Shin, Park, Heui Sul, Kim, Dong Wook, Song, Myoungsub, Yim, Hyeon Joo, Seo, Dong Ook, Kim, Soon Ha
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Animals APOPTOSIS Biological and medical sciences Cardiology. Vascular system Cardiomyopathies - chemically induced Cardiomyopathies - enzymology Cardiomyopathies - prevention & control Cardiomyopathy Cardiotonic Agents - pharmacology Cell Line CREATINE Creatine Kinase - blood DOXORUBICIN Doxorubicin - pharmacology Free Radical Scavengers - pharmacology Heart IN VITRO IN VIVO INHIBITION L-Lactate Dehydrogenase - blood LACTATE DEHYDROGENASE Male Medical sciences Microarray Analysis MITOCHONDRIA Myocarditis. Cardiomyopathies Myocytes, Cardiac - drug effects NADPH oxidase NADPH Oxidases - antagonists & inhibitors NECROSIS NecroX-7 Organic Chemicals - pharmacology OXIDASES OXIDATION Oxidative Stress - drug effects RATS Rats, Sprague-Dawley Real-Time Polymerase Chain Reaction tert-Butyl hydroperoxide tert-Butylhydroperoxide - antagonists & inhibitors Toxicology
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