Protein kinase B/Akt1 inhibits autophagy by down-regulating UVRAG expression

Autophagy, or autophagocytosis, is a selective intracellular degradative process involving the cell's own lysosomal apparatus. An essential component in cell development, homeostasis, repair and resistance to stress, autophagy may result in either cell death or survival. The targeted region of...

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Veröffentlicht in:	Experimental cell research 2013-02, Vol.319 (3), p.122-133
Hauptverfasser:	Yang, Wonseok, Ju, Ji-hyun, Lee, Kyung-min, Nam, KeeSoo, Oh, Sunhwa, Shin, Incheol
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Akt1 APOPTOSIS Autophagy Autophagy - drug effects Autophagy - genetics Autophagy - physiology Autophagy - radiation effects BIOLOGICAL REPAIR Cancer Cell Proliferation - drug effects Cell Proliferation - radiation effects Cells, Cultured Cellular biology Down-Regulation - drug effects Down-Regulation - genetics Down-Regulation - radiation effects Gene expression Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - radiation effects GENES HOMEOSTASIS Humans IRRADIATION Kinases LC3B MAMMARY GLANDS Mutation MUTATIONS NEOPLASMS Neoplasms - genetics Neoplasms - pathology PHOSPHORYLATION Protein Kinase Inhibitors - pharmacology Protein Processing, Post-Translational - drug effects PROTEINS Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-akt - physiology RNA, Small Interfering - pharmacology SERINE THREONINE TRANSCRIPTION Transfection Tumor Suppressor Proteins - antagonists & inhibitors Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Ultraviolet Rays UVRAG
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