Oxidative stress is involved in Dasatinib-induced apoptosis in rat primary hepatocytes

Dasatinib, a multitargeted inhibitor of BCR–ABL and SRC kinases, exhibits antitumor activity and extends the survival of patients with chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL). However, some patients suffer from hepatotoxicity, which occu...

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Veröffentlicht in:	Toxicology and applied pharmacology 2012-06, Vol.261 (3), p.280-291
Hauptverfasser:	Xue, Tao, Luo, Peihua, Zhu, Hong, Zhao, Yuqin, Wu, Honghai, Gai, Renhua, Wu, Youping, Yang, Bo, Yang, Xiaochun, He, Qiaojun
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Abl protein Acetylcysteine Acetylcysteine - pharmacology Alanine transaminase Alanine Transaminase - blood ALANINES Animals ANTIOXIDANTS Antioxidants - pharmacology Antitumor activity APOPTOSIS Apoptosis - drug effects Biological and medical sciences BIOLOGICAL STRESS Blotting, Western Caspase-3 Cell Separation CHROMATIN Chronic myeloid leukemia Dasatinib DNA - chemistry Electrophoresis, Gel, Pulsed-Field Fluorescent Dyes Free radicals GLUTATHIONE Hepatocytes Hepatocytes - drug effects Hepatotoxicity In Situ Nick-End Labeling IN VITRO IN VIVO Indoles INJURIES L-Lactate dehydrogenase L-Lactate Dehydrogenase - blood LABELLING LACTATE DEHYDROGENASE LIPIDS LIVER CELLS Male MAP kinase Medical sciences Membrane Potential, Mitochondrial - drug effects MITOCHONDRIA Mitochondria, Liver - drug effects Mitochondrial Swelling - drug effects MYELOID LEUKEMIA OXIDATION Oxidative stress Oxidative Stress - drug effects PHILADELPHIA CHROMOSOME PHOSPHOTRANSFERASES Protein Kinase Inhibitors - toxicity Pyrimidines - toxicity RATS Rats, Sprague-Dawley Reactive oxygen species Reactive Oxygen Species - metabolism SUPEROXIDE DISMUTASE Thiazoles - toxicity Toxicology
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