Rat liver mitochondrial damage under acute or chronic carbon tetrachloride-induced intoxication: Protection by melatonin and cranberry flavonoids

In current societies, the risk of toxic liver damage has markedly increased. The aim of the present work was to carry out further research into the mechanism(s) of liver mitochondrial damage induced by acute (0.8g/kg body weight, single injection) or chronic (1.6g/ kg body weight, 30days, biweekly i...

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Veröffentlicht in:	Toxicology and applied pharmacology 2012-06, Vol.261 (3), p.271-279
Hauptverfasser:	Cheshchevik, V.T., Lapshina, E.A., Dremza, I.K., Zabrodskaya, S.V., Reiter, R.J., Prokopchik, N.I., Zavodnik, I.B.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Acute Disease Acute intoxication Alanine transaminase Alanine Transaminase - blood ALANINES Animals ANTIOXIDANTS Antioxidants - pharmacology Aspartate aminotransferase Aspartate Aminotransferases - blood BILIRUBIN Bilirubin - blood Biological and medical sciences Body weight Carbon CARBON TETRACHLORIDE Carbon Tetrachloride Poisoning - pathology CATALASE Chronic Disease Chronic intoxication Cranberry flavonoids Electron transport Enzymes FLAVONOIDS Flavonoids - pharmacology GLUTATHIONE Hepatocytes Indicators and Reagents INJECTION Injuries Intoxication LIVER LIVER CELLS Male Medical sciences MELATONIN Melatonin - pharmacology Microscopy, Electron MITOCHONDRIA Mitochondria, Liver - drug effects Mitochondria, Liver - pathology Mitochondria, Liver - ultrastructure NITRIC OXIDE Nitric Oxide - blood Oxidative Stress - drug effects Oxygen Consumption - drug effects Preservation RATS Rats, Wistar Succinate dehydrogenase Succinate Dehydrogenase - metabolism Succinates - pharmacology TOXICITY Toxicology Urea - blood Vaccinium macrocarpon - chemistry
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