Actions of juglone on energy metabolism in the rat liver

Juglone is a phenolic compound used in popular medicine as a phytotherapic to treat inflammatory and infectious diseases. However, it also acts as an uncoupler of oxidative phosphorylation in isolated liver mitochondria and, thus, may interfere with the hepatic energy metabolism. The purpose of this...

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Veröffentlicht in:	Toxicology and applied pharmacology 2011-12, Vol.257 (3), p.319-327
Hauptverfasser:	Saling, Simoni Cristina, Comar, Jurandir Fernando, Mito, Márcio Shigueaki, Peralta, Rosane Marina, Bracht, Adelar
Format:	Artikel
Sprache:	eng
Schlagworte:	2,4-Dinitrophenol - toxicity 60 APPLIED LIFE SCIENCES ABUNDANCE Adenosine Triphosphate - metabolism ADP Alanine - drug effects Alanine - metabolism ALANINES AMMONIA AMP Animals ATP Biological and medical sciences CONCENTRATION RATIO DINITROPHENOL Dose-Response Relationship, Drug Energy Metabolism - drug effects Gluconeogenesis Glycogenolysis - drug effects GLYCOLYSIS Glycolysis - drug effects HYPERTHERMIA INFECTIOUS DISEASES INFLAMMATION INGESTION LACTATE DEHYDROGENASE LACTATES LIVER Liver - drug effects Liver - metabolism Liver toxicity Male Medical sciences MITOCHONDRIA Mitochondria, Liver - drug effects Mitochondria, Liver - metabolism Naphthoquinones - administration & dosage Naphthoquinones - toxicity Oxygen Consumption - drug effects Oxygen uptake PHOSPHORYLATION RATS Rats, Wistar TOXICITY Toxicology UREA Ureogenesis
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