Akt2 and nucleophosmin/B23 function as an oncogenic unit in human lung cancer cells

The signaling network of protein kinase B(PKB)/Akt has been implicated in survival of lung cancer cells. However, understanding the relative contribution of the different isoform of Akt network is nontrival. Here, we report that Akt2 is highly expressed in human lung adenocarcinoma cell line A549 ce...

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Veröffentlicht in:	Experimental cell research 2011-04, Vol.317 (7), p.966-975
Hauptverfasser:	Kim, Chung Kwon, Nguyen, Truong L.X., Lee, Sang Bae, Park, Sang Bum, Lee, Kyung-Hoon, Cho, Sung-Woo, Ahn, Jee-Yin
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES A549 AGAR Akt2 Apoptosis CARCINOMAS CELL CYCLE CELL PROLIFERATION Cell Transformation, Neoplastic Cellular biology Humans INHIBITION Invasion Isoenzymes - genetics Isoenzymes - metabolism Kinases Lung cancer Lung Neoplasms - genetics Lung Neoplasms - metabolism LUNGS Nuclear Proteins - genetics Nuclear Proteins - metabolism Nucleophosmin(B23) Oncogenes Proliferation PROTEINS Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism RNA, Small Interfering - metabolism Signal Transduction - physiology Tumor Suppressor Protein p53 - metabolism Tumorigenesis Tumors
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