Induction of mitochondrial biogenesis and respiration is associated with mTOR regulation in hepatocytes of rats treated with the pan-PPAR activator tetradecylthioacetic acid (TTA)

► We investigated mechanisms of mitochondrial regulation in rat hepatocytes. ► Tetradecylthioacetic acid (TTA) was employed to activate mitochondrial oxidation. ► Mitochondrial biogenesis and respiration were induced. ► It was confirmed that PPAR target genes were induced. ► The mechanism involved a...

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Veröffentlicht in:	Biochemical and biophysical research communications 2013-01, Vol.430 (2), p.573-578
Hauptverfasser:	Hagland, Hanne R., Nilsson, Linn I.H., Burri, Lena, Nikolaisen, Julie, Berge, Rolf K., Tronstad, Karl J.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Animals BIOLOGICAL MARKERS CARBOXYLIC ACIDS Cell Enlargement Cells, Cultured DNA Hepatocytes - drug effects Hepatocytes - enzymology Hepatocytes - ultrastructure HYPERTROPHY Hypolipidemic Agents - pharmacology LIVER LIVER CELLS Male MESSENGER-RNA MITOCHONDRIA Mitochondria, Liver - drug effects Mitochondria, Liver - enzymology Mitochondrial biogenesis Mitochondrial respiration Mitochondrial Turnover - drug effects mTOR OXIDATION Oxidation-Reduction Oxidative Phosphorylation - drug effects Oxygen Consumption - drug effects Peroxisome Proliferator-Activated Receptors - agonists PHOSPHORYLATION PPAR Rat hepatocytes RATS Rats, Wistar RECEPTORS RESPIRATION Sulfides - pharmacology TOR Serine-Threonine Kinases - metabolism TTA
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