Stanniocalcin-2 is a HIF-1 target gene that promotes cell proliferation in hypoxia

Stanniocalcin-2 (STC2), the paralog of STC1, has been suggested as a novel target of oxidative stress response to protect cells from apoptosis. The expression of STC2 has been reported to be highly correlated with human cancer development. In this study, we reported that STC2 is a HIF-1 target gene...

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Veröffentlicht in:	Experimental cell research 2010-02, Vol.316 (3), p.466-476
Hauptverfasser:	Law, Alice Y.S., Wong, Chris K.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ANOXIA APOPTOSIS Base Sequence Binding sites Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer CELL CYCLE Cell Cycle Proteins - metabolism Cell Hypoxia - drug effects Cell Hypoxia - genetics CELL PROLIFERATION Cell Proliferation - drug effects Cellular biology ChIP assay Disulfides - pharmacology E1A-Associated p300 Protein - metabolism Female Gene Expression Regulation, Neoplastic - drug effects GENE REGULATION Glycoproteins - genetics Glycoproteins - metabolism HDAC7 Histone Deacetylases - metabolism Humans Hydroxamic Acids - pharmacology Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Indole Alkaloids - pharmacology Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Luciferases - metabolism MAMMARY GLANDS Molecular Sequence Data MUTAGENESIS NEOPLASMS Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology OXIDATION p300 Promoter analysis PROMOTERS PROTEINS Response Elements - genetics Time Factors X-box binding protein
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