British Society of Interventional Radiology (BSIR) Inferior Vena Cava (IVC) Filter Registry

Purpose The British Society of Interventional Radiology (BSIR) Inferior Vena Cava (IVC) Filter Registry was produced to provide an audit of current United Kingdom (UK) practice regarding placement and retrieval of IVC filters to address concerns regarding their safety. Methods The IVC filter registr...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cardiovascular and interventional radiology 2013-12, Vol.36 (6), p.1548-1561
Hauptverfasser: Uberoi, Raman, Tapping, Charles Ross, Chalmers, Nicholas, Allgar, Victoria
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 1561
container_issue 6
container_start_page 1548
container_title Cardiovascular and interventional radiology
container_volume 36
creator Uberoi, Raman
Tapping, Charles Ross
Chalmers, Nicholas
Allgar, Victoria
description Purpose The British Society of Interventional Radiology (BSIR) Inferior Vena Cava (IVC) Filter Registry was produced to provide an audit of current United Kingdom (UK) practice regarding placement and retrieval of IVC filters to address concerns regarding their safety. Methods The IVC filter registry is a web-based registry, launched by the BSIR on behalf of its membership in October 2007. This report is based on prospectively collected data from October 2007 to March 2011. This report contains analysis of data on 1,434 IVC filter placements and 400 attempted retrievals performed at 68 UK centers. Data collected included patient demographics, insertion and retrieval data, and patient follow-up. Results IVC filter use in the majority of patients in the UK follows accepted CIRSE guidelines. Filter placement is usually a low-risk procedure, with a low major complication rate (
doi_str_mv 10.1007/s00270-013-0606-2
format Article
fullrecord <record><control><sourceid>proquest_osti_</sourceid><recordid>TN_cdi_osti_scitechconnect_22207968</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1448210306</sourcerecordid><originalsourceid>FETCH-LOGICAL-c509t-7f3f0affd6868c436c214fc239b1cac763bb219f056ae04bb141490db05822e83</originalsourceid><addsrcrecordid>eNp1kcFOGzEQhi3UCgLlAbggS1zCYcuM7fXuHiEqbSSkSoGiSj1YXscORps1tR2kvD2bLqVcevJhvv8feT5CThA-I0B1kQBYBQUgL0CCLNgemaDgrIBa_vxAJoCVKLAs8YAcpvQIgGXNyn1ywHiJ2DRsQn5dRZ99eqC3wXibtzQ4Ou-zjc-2zz70uqMLvfShC6stnV7dzhfnw9zZ6EOk97bXdKafNZ3O72fn9Np3Q5Iu7MqnHLefyEenu2SPX98j8uP6y93sW3Hz_et8dnlTmBKaXFSOO9DOLWUtayO4NAyFM4w3LRptKsnblmHjoJTagmhbFCgaWLYw_IbZmh-Rs7E3pOxVMj5b82BC31uTFWMMqkbuqOlIPcXwe2NTVmufjO063duwSQqFqBkCB_mv8A19DJs43OIPVQnZML6jcKRMDClF69RT9GsdtwpB7fyo0Y8a_KidH8WGzOlr86Zd2-Vb4q-QAWAjkIZRv7Lx3er_tr4AFimXcg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1447469236</pqid></control><display><type>article</type><title>British Society of Interventional Radiology (BSIR) Inferior Vena Cava (IVC) Filter Registry</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Uberoi, Raman ; Tapping, Charles Ross ; Chalmers, Nicholas ; Allgar, Victoria</creator><creatorcontrib>Uberoi, Raman ; Tapping, Charles Ross ; Chalmers, Nicholas ; Allgar, Victoria</creatorcontrib><description>Purpose The British Society of Interventional Radiology (BSIR) Inferior Vena Cava (IVC) Filter Registry was produced to provide an audit of current United Kingdom (UK) practice regarding placement and retrieval of IVC filters to address concerns regarding their safety. Methods The IVC filter registry is a web-based registry, launched by the BSIR on behalf of its membership in October 2007. This report is based on prospectively collected data from October 2007 to March 2011. This report contains analysis of data on 1,434 IVC filter placements and 400 attempted retrievals performed at 68 UK centers. Data collected included patient demographics, insertion and retrieval data, and patient follow-up. Results IVC filter use in the majority of patients in the UK follows accepted CIRSE guidelines. Filter placement is usually a low-risk procedure, with a low major complication rate (&lt;0.5 %). Cook Gunther Tulip (560 filters: 39 %) and Celect (359 filters: 25 %) filters constituted the majority of IVC filters inserted, with Bard G2, Recovery filters, Cordis Trapease, and OptEase constituting most of the remainder (445 filters: 31 %). More than 96 % of IVC filters deployed as intended. Operator inexperience (&lt;25 procedure) was significantly associated with complications ( p  &lt; 0.001). Of the IVC filters initially intended for temporary placement, retrieval was attempted in 78 %. Of these retrieval was technically successful in 83 %. Successful retrieval was significantly reduced for implants left in situ for &gt;9 weeks versus those with a shorter dwell time. New lower limb deep vein thrombosis (DVT) and/or IVC thrombosis was reported in 88 patients following filter placement, there was no significant difference of incidence between filter types. Conclusions This registry report provides interventional radiologists and clinicians with an improved understanding of the technical aspects of IVC filter placement to help improve practice, and the potential consequences of IVC filter placement so that we are better able to advise patients. There is a significant learning curve associated with IVC filter insertion, and when a filter is placed with the intention of removal, procedures should be in place to avoid the patient being lost to follow-up.</description><identifier>ISSN: 0174-1551</identifier><identifier>EISSN: 1432-086X</identifier><identifier>DOI: 10.1007/s00270-013-0606-2</identifier><identifier>PMID: 23511992</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Age Distribution ; Aged ; Aged, 80 and over ; BIOMEDICAL RADIOGRAPHY ; Cardiology ; Clinical Investigation ; DATA ANALYSIS ; Device Removal - statistics &amp; numerical data ; Female ; HEALTH HAZARDS ; Humans ; Imaging ; IMPLANTS ; LIMBS ; Male ; Medicine ; Medicine &amp; Public Health ; Middle Aged ; Nuclear Medicine ; PATIENTS ; Practice Guidelines as Topic ; Pulmonary Embolism - surgery ; Radiology ; RADIOLOGY AND NUCLEAR MEDICINE ; Radiology, Interventional - statistics &amp; numerical data ; RECOMMENDATIONS ; Registries - statistics &amp; numerical data ; Societies, Medical ; THROMBOSIS ; Time Factors ; Treatment Outcome ; Ultrasound ; UNITED KINGDOM ; VEINS ; Vena Cava Filters - statistics &amp; numerical data ; Vena Cava, Inferior - surgery ; Venous Thromboembolism - surgery ; Young Adult</subject><ispartof>Cardiovascular and interventional radiology, 2013-12, Vol.36 (6), p.1548-1561</ispartof><rights>Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-7f3f0affd6868c436c214fc239b1cac763bb219f056ae04bb141490db05822e83</citedby><cites>FETCH-LOGICAL-c509t-7f3f0affd6868c436c214fc239b1cac763bb219f056ae04bb141490db05822e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00270-013-0606-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00270-013-0606-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23511992$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/22207968$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Uberoi, Raman</creatorcontrib><creatorcontrib>Tapping, Charles Ross</creatorcontrib><creatorcontrib>Chalmers, Nicholas</creatorcontrib><creatorcontrib>Allgar, Victoria</creatorcontrib><title>British Society of Interventional Radiology (BSIR) Inferior Vena Cava (IVC) Filter Registry</title><title>Cardiovascular and interventional radiology</title><addtitle>Cardiovasc Intervent Radiol</addtitle><addtitle>Cardiovasc Intervent Radiol</addtitle><description>Purpose The British Society of Interventional Radiology (BSIR) Inferior Vena Cava (IVC) Filter Registry was produced to provide an audit of current United Kingdom (UK) practice regarding placement and retrieval of IVC filters to address concerns regarding their safety. Methods The IVC filter registry is a web-based registry, launched by the BSIR on behalf of its membership in October 2007. This report is based on prospectively collected data from October 2007 to March 2011. This report contains analysis of data on 1,434 IVC filter placements and 400 attempted retrievals performed at 68 UK centers. Data collected included patient demographics, insertion and retrieval data, and patient follow-up. Results IVC filter use in the majority of patients in the UK follows accepted CIRSE guidelines. Filter placement is usually a low-risk procedure, with a low major complication rate (&lt;0.5 %). Cook Gunther Tulip (560 filters: 39 %) and Celect (359 filters: 25 %) filters constituted the majority of IVC filters inserted, with Bard G2, Recovery filters, Cordis Trapease, and OptEase constituting most of the remainder (445 filters: 31 %). More than 96 % of IVC filters deployed as intended. Operator inexperience (&lt;25 procedure) was significantly associated with complications ( p  &lt; 0.001). Of the IVC filters initially intended for temporary placement, retrieval was attempted in 78 %. Of these retrieval was technically successful in 83 %. Successful retrieval was significantly reduced for implants left in situ for &gt;9 weeks versus those with a shorter dwell time. New lower limb deep vein thrombosis (DVT) and/or IVC thrombosis was reported in 88 patients following filter placement, there was no significant difference of incidence between filter types. Conclusions This registry report provides interventional radiologists and clinicians with an improved understanding of the technical aspects of IVC filter placement to help improve practice, and the potential consequences of IVC filter placement so that we are better able to advise patients. There is a significant learning curve associated with IVC filter insertion, and when a filter is placed with the intention of removal, procedures should be in place to avoid the patient being lost to follow-up.</description><subject>Adult</subject><subject>Age Distribution</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>BIOMEDICAL RADIOGRAPHY</subject><subject>Cardiology</subject><subject>Clinical Investigation</subject><subject>DATA ANALYSIS</subject><subject>Device Removal - statistics &amp; numerical data</subject><subject>Female</subject><subject>HEALTH HAZARDS</subject><subject>Humans</subject><subject>Imaging</subject><subject>IMPLANTS</subject><subject>LIMBS</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Middle Aged</subject><subject>Nuclear Medicine</subject><subject>PATIENTS</subject><subject>Practice Guidelines as Topic</subject><subject>Pulmonary Embolism - surgery</subject><subject>Radiology</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>Radiology, Interventional - statistics &amp; numerical data</subject><subject>RECOMMENDATIONS</subject><subject>Registries - statistics &amp; numerical data</subject><subject>Societies, Medical</subject><subject>THROMBOSIS</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Ultrasound</subject><subject>UNITED KINGDOM</subject><subject>VEINS</subject><subject>Vena Cava Filters - statistics &amp; numerical data</subject><subject>Vena Cava, Inferior - surgery</subject><subject>Venous Thromboembolism - surgery</subject><subject>Young Adult</subject><issn>0174-1551</issn><issn>1432-086X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kcFOGzEQhi3UCgLlAbggS1zCYcuM7fXuHiEqbSSkSoGiSj1YXscORps1tR2kvD2bLqVcevJhvv8feT5CThA-I0B1kQBYBQUgL0CCLNgemaDgrIBa_vxAJoCVKLAs8YAcpvQIgGXNyn1ywHiJ2DRsQn5dRZ99eqC3wXibtzQ4Ou-zjc-2zz70uqMLvfShC6stnV7dzhfnw9zZ6EOk97bXdKafNZ3O72fn9Np3Q5Iu7MqnHLefyEenu2SPX98j8uP6y93sW3Hz_et8dnlTmBKaXFSOO9DOLWUtayO4NAyFM4w3LRptKsnblmHjoJTagmhbFCgaWLYw_IbZmh-Rs7E3pOxVMj5b82BC31uTFWMMqkbuqOlIPcXwe2NTVmufjO063duwSQqFqBkCB_mv8A19DJs43OIPVQnZML6jcKRMDClF69RT9GsdtwpB7fyo0Y8a_KidH8WGzOlr86Zd2-Vb4q-QAWAjkIZRv7Lx3er_tr4AFimXcg</recordid><startdate>20131201</startdate><enddate>20131201</enddate><creator>Uberoi, Raman</creator><creator>Tapping, Charles Ross</creator><creator>Chalmers, Nicholas</creator><creator>Allgar, Victoria</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>20131201</creationdate><title>British Society of Interventional Radiology (BSIR) Inferior Vena Cava (IVC) Filter Registry</title><author>Uberoi, Raman ; Tapping, Charles Ross ; Chalmers, Nicholas ; Allgar, Victoria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-7f3f0affd6868c436c214fc239b1cac763bb219f056ae04bb141490db05822e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Age Distribution</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>BIOMEDICAL RADIOGRAPHY</topic><topic>Cardiology</topic><topic>Clinical Investigation</topic><topic>DATA ANALYSIS</topic><topic>Device Removal - statistics &amp; numerical data</topic><topic>Female</topic><topic>HEALTH HAZARDS</topic><topic>Humans</topic><topic>Imaging</topic><topic>IMPLANTS</topic><topic>LIMBS</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Middle Aged</topic><topic>Nuclear Medicine</topic><topic>PATIENTS</topic><topic>Practice Guidelines as Topic</topic><topic>Pulmonary Embolism - surgery</topic><topic>Radiology</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>Radiology, Interventional - statistics &amp; numerical data</topic><topic>RECOMMENDATIONS</topic><topic>Registries - statistics &amp; numerical data</topic><topic>Societies, Medical</topic><topic>THROMBOSIS</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Ultrasound</topic><topic>UNITED KINGDOM</topic><topic>VEINS</topic><topic>Vena Cava Filters - statistics &amp; numerical data</topic><topic>Vena Cava, Inferior - surgery</topic><topic>Venous Thromboembolism - surgery</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Uberoi, Raman</creatorcontrib><creatorcontrib>Tapping, Charles Ross</creatorcontrib><creatorcontrib>Chalmers, Nicholas</creatorcontrib><creatorcontrib>Allgar, Victoria</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Cardiovascular and interventional radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Uberoi, Raman</au><au>Tapping, Charles Ross</au><au>Chalmers, Nicholas</au><au>Allgar, Victoria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>British Society of Interventional Radiology (BSIR) Inferior Vena Cava (IVC) Filter Registry</atitle><jtitle>Cardiovascular and interventional radiology</jtitle><stitle>Cardiovasc Intervent Radiol</stitle><addtitle>Cardiovasc Intervent Radiol</addtitle><date>2013-12-01</date><risdate>2013</risdate><volume>36</volume><issue>6</issue><spage>1548</spage><epage>1561</epage><pages>1548-1561</pages><issn>0174-1551</issn><eissn>1432-086X</eissn><abstract>Purpose The British Society of Interventional Radiology (BSIR) Inferior Vena Cava (IVC) Filter Registry was produced to provide an audit of current United Kingdom (UK) practice regarding placement and retrieval of IVC filters to address concerns regarding their safety. Methods The IVC filter registry is a web-based registry, launched by the BSIR on behalf of its membership in October 2007. This report is based on prospectively collected data from October 2007 to March 2011. This report contains analysis of data on 1,434 IVC filter placements and 400 attempted retrievals performed at 68 UK centers. Data collected included patient demographics, insertion and retrieval data, and patient follow-up. Results IVC filter use in the majority of patients in the UK follows accepted CIRSE guidelines. Filter placement is usually a low-risk procedure, with a low major complication rate (&lt;0.5 %). Cook Gunther Tulip (560 filters: 39 %) and Celect (359 filters: 25 %) filters constituted the majority of IVC filters inserted, with Bard G2, Recovery filters, Cordis Trapease, and OptEase constituting most of the remainder (445 filters: 31 %). More than 96 % of IVC filters deployed as intended. Operator inexperience (&lt;25 procedure) was significantly associated with complications ( p  &lt; 0.001). Of the IVC filters initially intended for temporary placement, retrieval was attempted in 78 %. Of these retrieval was technically successful in 83 %. Successful retrieval was significantly reduced for implants left in situ for &gt;9 weeks versus those with a shorter dwell time. New lower limb deep vein thrombosis (DVT) and/or IVC thrombosis was reported in 88 patients following filter placement, there was no significant difference of incidence between filter types. Conclusions This registry report provides interventional radiologists and clinicians with an improved understanding of the technical aspects of IVC filter placement to help improve practice, and the potential consequences of IVC filter placement so that we are better able to advise patients. There is a significant learning curve associated with IVC filter insertion, and when a filter is placed with the intention of removal, procedures should be in place to avoid the patient being lost to follow-up.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>23511992</pmid><doi>10.1007/s00270-013-0606-2</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0174-1551
ispartof Cardiovascular and interventional radiology, 2013-12, Vol.36 (6), p.1548-1561
issn 0174-1551
1432-086X
language eng
recordid cdi_osti_scitechconnect_22207968
source MEDLINE; Springer Nature - Complete Springer Journals
subjects Adult
Age Distribution
Aged
Aged, 80 and over
BIOMEDICAL RADIOGRAPHY
Cardiology
Clinical Investigation
DATA ANALYSIS
Device Removal - statistics & numerical data
Female
HEALTH HAZARDS
Humans
Imaging
IMPLANTS
LIMBS
Male
Medicine
Medicine & Public Health
Middle Aged
Nuclear Medicine
PATIENTS
Practice Guidelines as Topic
Pulmonary Embolism - surgery
Radiology
RADIOLOGY AND NUCLEAR MEDICINE
Radiology, Interventional - statistics & numerical data
RECOMMENDATIONS
Registries - statistics & numerical data
Societies, Medical
THROMBOSIS
Time Factors
Treatment Outcome
Ultrasound
UNITED KINGDOM
VEINS
Vena Cava Filters - statistics & numerical data
Vena Cava, Inferior - surgery
Venous Thromboembolism - surgery
Young Adult
title British Society of Interventional Radiology (BSIR) Inferior Vena Cava (IVC) Filter Registry
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T23%3A20%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_osti_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=British%20Society%20of%20Interventional%20Radiology%20(BSIR)%20Inferior%20Vena%20Cava%20(IVC)%20Filter%20Registry&rft.jtitle=Cardiovascular%20and%20interventional%20radiology&rft.au=Uberoi,%20Raman&rft.date=2013-12-01&rft.volume=36&rft.issue=6&rft.spage=1548&rft.epage=1561&rft.pages=1548-1561&rft.issn=0174-1551&rft.eissn=1432-086X&rft_id=info:doi/10.1007/s00270-013-0606-2&rft_dat=%3Cproquest_osti_%3E1448210306%3C/proquest_osti_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1447469236&rft_id=info:pmid/23511992&rfr_iscdi=true