The enhancer of zeste homolog 2 (EZH2), a potential therapeutic target, is regulated by miR-101 in renal cancer cells

► EZH2 is overexpressed in the nuclei of renal cancer cells. ► Nuclear EZH2 is associated with advanced stage and worse survival of RCC patients. ► EZH2 is negatively regulated by miR-101 in renal cancer cells. ► Depletion of EZH2 leads to re-expression of p27Kip1. ► Reintroduction of miR-101 result...

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Veröffentlicht in:	Biochemical and biophysical research communications 2012-06, Vol.422 (4), p.607-614
Hauptverfasser:	Sakurai, Toshihiko, Bilim, Vladimir N., Ugolkov, Andrey V., Yuuki, Kaori, Tsukigi, Masaaki, Motoyama, Teiichi, Tomita, Yoshihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Adult Aged Aged, 80 and over Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Carcinoma, Renal Cell - drug therapy Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - mortality CARCINOMAS Cell Nucleus - metabolism CELL PROLIFERATION Cyclin-Dependent Kinase Inhibitor p27 - genetics DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Enhancer Elements, Genetic Enhancer of zeste homolog 2 Enhancer of Zeste Homolog 2 Protein Female Gene Expression Regulation, Neoplastic Humans INHIBITION Kidney Neoplasms - drug therapy Kidney Neoplasms - genetics Kidney Neoplasms - mortality KIDNEYS Male METHYL TRANSFERASES MicroRNA-101 MicroRNAs - genetics MicroRNAs - metabolism Middle Aged PATIENTS Polycomb Repressive Complex 2 Renal cell carcinoma RNA Interference Transcription Factors - genetics Transcription Factors - metabolism Tumor Cells, Cultured
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