Intracellular trafficking of superparamagnetic iron oxide nanoparticles conjugated with TAT peptide: 3-dimensional electron tomography analysis

[Display omitted] ► We study the intracellular localisation of TAT-SPIONs using 3-D electron tomography. ► 3-D images of TAT-SPIONs in a cell are clearly shown. ► Release of TAT-SPIONs from endocytic vesicles into the cytoplasm is clearly shown. Internalisation of nanoparticles conjugated with cell...

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Veröffentlicht in:	Biochemical and biophysical research communications 2012-05, Vol.421 (4), p.763-767
Hauptverfasser:	Nair, Baiju G., Fukuda, Takahiro, Mizuki, Toru, Hanajiri, Tatsuro, Maekawa, Toru
Format:	Artikel
Sprache:	eng
Schlagworte:	3-D tomography 60 APPLIED LIFE SCIENCES AIDS VIRUS Biological Transport Cell Line, Tumor Cell penetrating peptides CYTOPLASM Cytoplasm - metabolism Drug Delivery Systems DRUGS Electron Microscope Tomography Endocytic pathways Ferric Compounds - chemistry Ferric Compounds - metabolism Humans Internalisation IRON OXIDES Magnetite Nanoparticles Nanoparticles NANOSTRUCTURES Peptide Fragments - chemistry Peptide Fragments - metabolism PEPTIDES SUPERPARAMAGNETISM tat Gene Products, Human Immunodeficiency Virus - chemistry tat Gene Products, Human Immunodeficiency Virus - metabolism TOMOGRAPHY TOXICITY TRANSMISSION ELECTRON MICROSCOPY Transport Vesicles - metabolism
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