Conformation and dynamics of nucleotides in bulges and symmetric internal loops in duplex DNA studied by EPR and fluorescence spectroscopies

► Bulges and loops were studied by both EPR and fluorescence spectroscopies using the probe Ç/Çf. ► One-base bulge was in a temperature-dependent equilibrium between looped-out and stacked states. ► Bases in two- and three-base bulges were stacked at all temperatures, resulting in DNA bending. ► Bas...

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Veröffentlicht in:	Biochemical and biophysical research communications 2012-04, Vol.420 (3), p.656-661
Hauptverfasser:	Cekan, Pavol, Sigurdsson, Snorri Th
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Aminoxyl radical DNA DNA - chemistry ELECTRON SPIN RESONANCE Electron Spin Resonance Spectroscopy ESR FLUORESCENCE FLUORESCENCE SPECTROSCOPY Nitroxide Nucleic Acid Conformation NUCLEOTIDES Nucleotides - chemistry SDSL Site-directed spin-labeling Spectrometry, Fluorescence SPIN
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