Ionizing radiation accelerates Drp1-dependent mitochondrial fission, which involves delayed mitochondrial reactive oxygen species production in normal human fibroblast-like cells

► We report first time that ionizing radiation induces mitochondrial dynamic changes. ► Radiation-induced mitochondrial fission was caused by Drp1 localization. ► We found that radiation causes delayed ROS from mitochondria. ► Down regulation of Drp1 rescued mitochondrial dysfunction after radiation...

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Veröffentlicht in:	Biochemical and biophysical research communications 2011-11, Vol.414 (4), p.795-800
Hauptverfasser:	Kobashigawa, Shinko, Suzuki, Keiji, Yamashita, Shunichi
Format:	Artikel
Sprache:	eng
Schlagworte:	BIOLOGICAL RADIATION EFFECTS Cells, Cultured Drp1 FIBROBLASTS Fibroblasts - metabolism Fibroblasts - radiation effects Fibroblasts - ultrastructure Gamma Rays GENE REGULATION GTP Phosphohydrolases - genetics GTP Phosphohydrolases - metabolism Humans Ionizing radiation IONIZING RADIATIONS IRRADIATION Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism MITOCHONDRIA Mitochondria - metabolism Mitochondria - radiation effects Mitochondrial fission Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism PROTEINS RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS Reactive oxygen species Reactive Oxygen Species - metabolism Singlet Oxygen - metabolism
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