SREBP-1c regulates glucose-stimulated hepatic clusterin expression

► This is the first report to show nutrient-regulated clusterin expression. ► Clusterin expression in hepatocytes was increased by high glucose concentration. ► SREBP-1c is directly involved in the transcriptional activation of clusterin by glucose. ► This glucose-stimulated activation process is me...

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Veröffentlicht in:	Biochemical and biophysical research communications 2011-05, Vol.408 (4), p.720-725
Hauptverfasser:	Kim, Gukhan, Kim, Geun Hyang, Oh, Gyun-Sik, Yoon, Jin, Kim, Hae Won, Kim, Min-Seon, Kim, Seung-Whan
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ANIMAL TISSUES Animals Apolipoprotein J CELL PROLIFERATION Cells, Cultured Chromatin Immunoprecipitation Clusterin Clusterin - genetics CONCENTRATION RATIO E-box GLUCOSE Glucose - metabolism Glucose - pharmacology Hepatocytes - drug effects Hepatocytes - metabolism HEPATOMAS INFLAMMATION LIPIDS LIVER LIVER CELLS Mice NUCLEOTIDES PROTEINS Response Elements SREBP-1c Sterol Regulatory Element Binding Protein 1 - genetics Sterol Regulatory Element Binding Protein 1 - metabolism STEROLS Transcription, Genetic - drug effects Transcriptional Activation
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