The inhibition of MAPK potentiates the anti-angiogenic efficacy of mTOR inhibitors

► Targeting mTOR in endothelial cell activates MAPK. ► Blocking MAPK enhances the anti-angiogenic effects of mTOR inhibitors. ► The anti-angiogenic efficacy of ATP-competitive inhibitors of mTOR is superior to that of rapamycin. The mammalian target of rapamycin (mTOR) which is part of two functiona...

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Veröffentlicht in:	Biochemical and biophysical research communications 2011-04, Vol.407 (4), p.714-719
Hauptverfasser:	Dormond-Meuwly, Anne, Roulin, Didier, Dufour, Marc, Benoit, Michael, Demartines, Nicolas, Dormond, Olivier
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ANGIOGENESIS Angiogenesis Inhibitors - pharmacology Animals ATP Butadienes - pharmacology Cancer Cell Movement - drug effects CELL PROLIFERATION Cell Proliferation - drug effects Cell Survival - drug effects Cells, Cultured DMSO Endothelium Endothelium, Vascular - drug effects Endothelium, Vascular - enzymology Enzyme Inhibitors - pharmacology GROWTH GROWTH FACTORS Humans Imidazoles - pharmacology IN VITRO IN VIVO INHIBITION Male MAPK Mechanistic Target of Rapamycin Complex 1 Mice Mice, Nude Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors Morpholines - pharmacology mTOR Multiprotein Complexes NEOPLASMS Neoplasms - enzymology Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - enzymology Nitriles - pharmacology Proteins - antagonists & inhibitors Pyrimidines - pharmacology Quinolines - pharmacology Signaling SIGNALS Sirolimus - pharmacology TOR Serine-Threonine Kinases - antagonists & inhibitors Transcription Factors - antagonists & inhibitors VEINS
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