Transport of Poly( n-butylcyano-acrylate) nanoparticles across the blood–brain barrier in vitro and their influence on barrier integrity

► Poly( n-butylcyano-acrylate) (PBCA) nanoparticles may be promising drug carriers. ► Influence of PBCA nanoparticles on the integrity of the blood–brain barrier in vitro. ► PBCA nanoparticles lead to a reversible disruption of the BBB in vitro after 4 h. ► Potential application as time-dependent an...

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Veröffentlicht in:	Biochemical and biophysical research communications 2011-03, Vol.406 (1), p.64-69
Hauptverfasser:	Rempe, Ralf, Cramer, Sandra, Hüwel, Sabine, Galla, Hans-Joachim
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ACRYLATES Animals Biological Transport BLOOD-BRAIN BARRIER Blood-Brain Barrier - metabolism BRAIN CAPILLARIES CARBON 14 Carbon Radioisotopes - metabolism DIFFUSION BARRIERS Drug Carriers - chemistry Drug Carriers - metabolism Drug delivery DRUGS ELECTRIC CONDUCTIVITY Enbucrilate - chemistry Fluorescein-5-isothiocyanate - metabolism IN VITRO In vitro blood-brain barrier Nanoparticles Nanoparticles - chemistry NANOSTRUCTURES ORTHORHOMBIC LATTICES Poly( n-butylcyano-acrylate) Polysorbate 80 Polysorbates - chemistry SACCHAROSE Serum Albumin - metabolism Sucrose - metabolism Swine Transendothelial electrical resistance
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