WNT signaling controls expression of pro-apoptotic BOK and BAX in intestinal cancer

► Intestinal adenomas initiated by aberrant activation of the WNT pathway displayed an increased sensitivity to apoptosis. ► Expression profiling of apoptosis-related genes in Apc Min / + mice revealed the differential expression of pro-apoptotic Bok and Bax. ► APC-mutant adenomatous crypts in FAP p...

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Veröffentlicht in:	Biochemical and biophysical research communications 2011-03, Vol.406 (1), p.1-6
Hauptverfasser:	Zeilstra, Jurrit, Joosten, Sander P.J., Wensveen, Felix M., Dessing, Mark C., Schütze, Denise M., Eldering, Eric, Spaargaren, Marcel, Pals, Steven T.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Adenoma - genetics Adenoma - metabolism ADENOMAS Adult ANIMAL TISSUES Animals APOPTOSIS BAX bcl-2-Associated X Protein - biosynthesis bcl-2-Associated X Protein - genetics BOK CELL PROLIFERATION Colorectal cancer Female Gene Expression Regulation, Neoplastic GENE REGULATION GENES Humans Intestinal Neoplasms - genetics Intestinal Neoplasms - metabolism LARGE INTESTINE Male MICE MUTANTS MUTATIONS PATIENTS Proto-Oncogene Proteins c-bcl-2 - biosynthesis Proto-Oncogene Proteins c-bcl-2 - genetics Signal Transduction STEM CELLS TRANSCRIPTION Wnt Proteins - genetics Wnt Proteins - metabolism WNT signaling Young Adult
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