Insulin-like growth factor-binding protein-5 (IGFBP-5) inhibits TNF-{alpha}-induced NF-{kappa}B activity by binding to TNFR1

Research highlights: {yields} Binding assays demonstrated that secreted- and cellular-IGFBP-5 interacted with TNFR1. {yields} The interaction between IGFBP-5 and TNFR1 was inhibited by TNF-{alpha} and was blocked TNF-{alpha}-activated NF-{kappa}B activity. {yields} IGFBP-5 interacted with TNFR1 thro...

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Veröffentlicht in:	Biochemical and biophysical research communications 2011-02, Vol.405 (4)
Hauptverfasser:	Hwang, Jae Ryoung, Huh, Jae Ho, Lee, Yoonna, Lee, Sang Il, Rho, Seung Bae, Lee, Je-Ho, Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES APOPTOSIS CELL PROLIFERATION GENES GROWTH FACTORS IN VITRO IN VIVO INHIBITION INSULIN LIGANDS MUTANTS RECEPTORS
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