miR-181a shows tumor suppressive effect against oral squamous cell carcinoma cells by downregulating K-ras

► MicroRNA-181a (miR-181a) was frequently downregulated in oral squamous cell carcinoma (OSCC). ► Overexpression of miR-181a suppressed OSCC growth. ► K-ras is a novel target of miR-181a. ► Decreased miR-181a expression is attributed to its lower promoter activity in OSCC. MicroRNAs (miRNAs) are epi...

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Veröffentlicht in:	Biochemical and biophysical research communications 2011-01, Vol.404 (4), p.896-902
Hauptverfasser:	Shin, Ki-Hyuk, Bae, Susan D., Hong, Hannah S., Kim, Reuben H., Kang, Mo K., Park, No-Hee
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Base Sequence Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology CARCINOMAS Cell Line, Tumor CELL PROLIFERATION DEREGULATION Down-Regulation Gene Expression Regulation, Neoplastic Genes, ras Genes, Tumor Suppressor - physiology Humans K-ras LUCIFERASE MicroRNAs - genetics MicroRNAs - physiology miR-181a Mouth Neoplasms - genetics Mouth Neoplasms - pathology ONCOGENES Oral cancer Promoter Regions, Genetic PROMOTERS Tumor suppressor
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