Dependency of {gamma}-secretase complex activity on the structural integrity of the bilayer

Research highlights: {yields} Partial solubilization of membranes with CHAPSO can increase {gamma}-secretase activity. {yields} Completely solubilized {gamma}-secretase is inactive. {yields} Purified {gamma}-secretase regains activity after reconstitution into lipid bilayers. {yields} A broad range...

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Veröffentlicht in:	Biochemical and biophysical research communications 2010-11, Vol.402 (2)
Hauptverfasser:	Zhou, Hua, Zhou, Shuxia, Walian, Peter J., Jap, Bing K.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES CONCENTRATION RATIO DETERGENTS ELECTRON MICROSCOPY LIPIDS MEMBRANE PROTEINS NERVOUS SYSTEM DISEASES PEPTIDES PHARYNX
Online-Zugang:	Volltext
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