Rosiglitazone induces the unfolded protein response, but has no significant effect on cell viability, in monocytic and vascular smooth muscle cells

► Rosiglitazone rapidly (30 min) inhibited microsomal Ca 2+ATPase activity (IC 50 ∼2 μM). ► After 4 h rosiglitazone exposure, the UPR transcription factor XBP-1 was activated. ► Within 24–72 h, UPR target genes were upregulated, enhancing ER Ca 2+ sequestration. ► Replenishment of ER Ca 2+ stores ap...

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Veröffentlicht in:	Biochemical and biophysical research communications 2010-10, Vol.400 (4), p.689-695
Hauptverfasser:	Caddy, J., Isa, S., Mainwaring, L.S., Adam, E., Roberts, A., Lang, D., Morris, R.H.K., Thomas, A.W., Webb, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Ca super(2+)-transporting ATPase Calcium - metabolism CALCIUM IONS CARDIOVASCULAR SYSTEM Cell Line Cell Survival - drug effects CONCENTRATION RATIO CYTOPLASM DNA-Binding Proteins - metabolism ER stress Gene Expression - drug effects GENES Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism Homeostasis - drug effects Humans Hypoglycemic Agents - pharmacology INCUBATION INSULIN MICROSOMES MONOCYTES Monocytes - drug effects Monocytes - metabolism Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism MUSCLES Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism PHYSIOLOGY Regulatory Factor X Transcription Factors Rosiglitazone Sarcoplasmic Reticulum Calcium-Transporting ATPases - genetics Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism SERCA2b Thiazolidinediones - adverse effects Thiazolidinediones - pharmacology TRANSCRIPTION FACTORS Transcription Factors - metabolism Type 2 diabetes Unfolded Protein Response Vasodilator Agents - pharmacology VSMCs X-Box Binding Protein 1
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