Adhesion-mediated self-renewal abilities of Ph+ blastoma cells

The Philadelphia chromosome-positive blastoma, maintained by serial subcutaneous transplantation in nude mice, is a highly proliferating biological mass consisting of homogenous CD34 +CD38 − myeloblastoid cells. These cells newly evolved from pluripotent leukemia stem cells of chronic myeloid leukem...

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Veröffentlicht in:	Biochemical and biophysical research communications 2010-05, Vol.396 (2), p.193-198
Hauptverfasser:	Funayama, Keiji, Saito-Kurimoto, Yumi, Ebihara, Yasuhiro, Shimane, Miyuki, Nomura, Hitoshi, Tsuji, Ko-ichiro, Asano, Shigetaka
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Animals beta Catenin - metabolism Blastoma Cell Adhesion Cell Culture Techniques CELL PROLIFERATION Chronic myeloid leukemia Gene Expression Regulation, Leukemic GENE REGULATION Humans Hyaluronan Receptors - genetics Hyaluronan Receptors - metabolism IN VITRO Leukemic stem cell MICE Mice, Inbred NOD Mice, SCID MYELOID LEUKEMIA Neoplasm Transplantation Neoplastic Stem Cells - pathology Nuclear Proteins - genetics PH VALUE PHILADELPHIA CHROMOSOME Pluripotent Stem Cells - pathology Polycomb Repressive Complex 1 Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology Proto-Oncogene Proteins - genetics Receptor, Notch1 - metabolism Repressor Proteins - genetics Self-renewal ability STEM CELLS
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