Involvement of the endocannabinoid system in periodontal healing

Endocannabinoids including anandamide (AEA) and 2-arachidonoylglycerol (2-AG) are important lipid mediators for immunosuppressive effects and for appropriate homeostasis via their G-protein-coupled cannabinoid (CB) receptors in mammalian organs and tissues, and may be involved in wound healing in so...

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Veröffentlicht in:	Biochemical and biophysical research communications 2010-04, Vol.394 (4), p.928-933
Hauptverfasser:	Kozono, Sayaka, Matsuyama, Takashi, Biwasa, Kamal Krishna, Kawahara, Ko-ichi, Nakajima, Yumiko, Yoshimoto, Takehiko, Yonamine, Yutaka, Kadomatsu, Hideshi, Tancharoen, Salunya, Hashiguchi, Teruto, Noguchi, Kazuyuki, Maruyama, Ikuro
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Animals Arachidonic Acids - metabolism Arachidonic Acids - pharmacology Cannabinoid Receptor Modulators - metabolism Cannabinoid Receptor Modulators - pharmacology Cannabinoid receptors Cell Proliferation Endocannabinoids FIBROBLASTS Fibroblasts - drug effects Fibroblasts - metabolism Fibroblasts - physiology Gingival Crevicular Fluid - metabolism Gingival fibroblasts Glycerides - metabolism Glycerides - pharmacology GRANULATION GTP-ASES HEALING Humans IN VITRO Indoles - pharmacology LIPIDS MACROPHAGES Mitogen-activated protein kinases ORGANS p38 Mitogen-Activated Protein Kinases - metabolism Periodontium - injuries Periodontium - metabolism Phosphatidylinositol 3-Kinases - metabolism PHOSPHORYLATION PHOSPHOTRANSFERASES Piperidines - pharmacology Polyunsaturated Alkamides - metabolism Polyunsaturated Alkamides - pharmacology Proliferation Pyrazoles - pharmacology RATS Receptor, Cannabinoid, CB1 - antagonists & inhibitors Receptor, Cannabinoid, CB1 - metabolism Receptor, Cannabinoid, CB2 - antagonists & inhibitors Receptor, Cannabinoid, CB2 - metabolism RECEPTORS Wound Healing WOUNDS
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