Highly selective fusion and accumulation of hybrid liposomes into primary effusion lymphoma cells along with induction of apoptosis

Primary effusion lymphoma (PEL) is an aggressive neoplasm caused by human herpes virus-8 infection, and is generally resistant to chemotherapy. Hybrid liposomes, composed of dimyristoylphosphatidylcholine (DMPC) and polyoxyethylene (21) dodecyl ether (C 12(EO) 21) (HL-21), were rapidly accumulated i...

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Veröffentlicht in:	Biochemical and biophysical research communications 2010-03, Vol.393 (3), p.445-448
Hauptverfasser:	Towata, Tomomi, Komizu, Yuji, Suzu, Shinya, Ueoka, Ryuichi, Okada, Seiji
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES APOPTOSIS Caspase-3 Cell Line, Tumor Cell Membrane - metabolism CHEMOTHERAPY DIFFUSION Dimyristoylphosphatidylcholine - chemistry Dimyristoylphosphatidylcholine - metabolism ETHERS Human herpesvirus 8 HUMAN POPULATIONS Humans Hybrid liposome HYBRIDIZATION LIPOSOMES Liposomes - chemistry Liposomes - metabolism Lymphoma, Primary Effusion - metabolism LYMPHOMAS Membrane Fluidity Membrane Fusion PHOSPHOLIPIDS Polyethylene Glycols - chemistry Polyethylene Glycols - metabolism Primary effusion lymphoma VIRUSES
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