Highly selective fusion and accumulation of hybrid liposomes into primary effusion lymphoma cells along with induction of apoptosis
Primary effusion lymphoma (PEL) is an aggressive neoplasm caused by human herpes virus-8 infection, and is generally resistant to chemotherapy. Hybrid liposomes, composed of dimyristoylphosphatidylcholine (DMPC) and polyoxyethylene (21) dodecyl ether (C 12(EO) 21) (HL-21), were rapidly accumulated i...
Gespeichert in:
| Veröffentlicht in: | Biochemical and biophysical research communications 2010-03, Vol.393 (3), p.445-448 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 448 |
|---|---|
| container_issue | 3 |
| container_start_page | 445 |
| container_title | Biochemical and biophysical research communications |
| container_volume | 393 |
| creator | Towata, Tomomi Komizu, Yuji Suzu, Shinya Ueoka, Ryuichi Okada, Seiji |
| description | Primary effusion lymphoma (PEL) is an aggressive neoplasm caused by human herpes virus-8 infection, and is generally resistant to chemotherapy. Hybrid liposomes, composed of dimyristoylphosphatidylcholine (DMPC) and polyoxyethylene (21) dodecyl ether (C
12(EO)
21) (HL-21), were rapidly accumulated in the membrane of PEL cells. HL-21 also increased membrane fluidity of PEL cells, and induced caspase-3 activation along with cell death. These results suggest that HL-21 should be an effective and attractive regent for PEL treatment. |
| doi_str_mv | 10.1016/j.bbrc.2010.02.016 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_osti_</sourceid><recordid>TN_cdi_osti_scitechconnect_22202406</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006291X10002160</els_id><sourcerecordid>877573090</sourcerecordid><originalsourceid>FETCH-LOGICAL-c415t-a628971dd1f820dc649aa234b2177c424f278051c3051516b01c632712c7303a3</originalsourceid><addsrcrecordid>eNqFkU1r3DAYhEVpabZp_0APRdBDT96--ljLhl5KaJJCIJcGchOyJMdaZMuV5IQ9549XZjc9thcJhmcG5h2EPhLYEiD11_2266LeUigC0G2RXqENgRYqSoC_RhsAqCvakvsz9C6lPQAhvG7forNiYU3D-AY9X7uHwR9wst7q7B4t7pfkwoTVZLDSehkXr_IqhB4Phy46g72bQwqjTdhNOeA5ulHFA7b9yeoP4zyEUWFtvU9Y-TA94CeXh8KbRb-kqTnMOSSX3qM3vfLJfjj95-ju8sevi-vq5vbq58X3m0pzssuVqmnTCmIM6RsKRte8VYoy3lEihOaU91Q0sCOalWdH6g6IrhkVhGrBgCl2jj4fc0PKTibtstWDDtNUmktKKVAOdaG-HKk5ht-LTVmOLq1N1GTDkmQjxK7ktfBfUjAmypWbtpD0SOoYUoq2l6ejSQJy3VLu5bqlXLeUQGWRiunTKX7pRmv-Wl7GK8C3I2DL0R6djWsnO2lrXFwrmeD-lf8Holqwag</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733788389</pqid></control><display><type>article</type><title>Highly selective fusion and accumulation of hybrid liposomes into primary effusion lymphoma cells along with induction of apoptosis</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Towata, Tomomi ; Komizu, Yuji ; Suzu, Shinya ; Ueoka, Ryuichi ; Okada, Seiji</creator><creatorcontrib>Towata, Tomomi ; Komizu, Yuji ; Suzu, Shinya ; Ueoka, Ryuichi ; Okada, Seiji</creatorcontrib><description>Primary effusion lymphoma (PEL) is an aggressive neoplasm caused by human herpes virus-8 infection, and is generally resistant to chemotherapy. Hybrid liposomes, composed of dimyristoylphosphatidylcholine (DMPC) and polyoxyethylene (21) dodecyl ether (C
12(EO)
21) (HL-21), were rapidly accumulated in the membrane of PEL cells. HL-21 also increased membrane fluidity of PEL cells, and induced caspase-3 activation along with cell death. These results suggest that HL-21 should be an effective and attractive regent for PEL treatment.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2010.02.016</identifier><identifier>PMID: 20138834</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>60 APPLIED LIFE SCIENCES ; APOPTOSIS ; Caspase-3 ; Cell Line, Tumor ; Cell Membrane - metabolism ; CHEMOTHERAPY ; DIFFUSION ; Dimyristoylphosphatidylcholine - chemistry ; Dimyristoylphosphatidylcholine - metabolism ; ETHERS ; Human herpesvirus 8 ; HUMAN POPULATIONS ; Humans ; Hybrid liposome ; HYBRIDIZATION ; LIPOSOMES ; Liposomes - chemistry ; Liposomes - metabolism ; Lymphoma, Primary Effusion - metabolism ; LYMPHOMAS ; Membrane Fluidity ; Membrane Fusion ; PHOSPHOLIPIDS ; Polyethylene Glycols - chemistry ; Polyethylene Glycols - metabolism ; Primary effusion lymphoma ; VIRUSES</subject><ispartof>Biochemical and biophysical research communications, 2010-03, Vol.393 (3), p.445-448</ispartof><rights>2010 Elsevier Inc.</rights><rights>2010 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-a628971dd1f820dc649aa234b2177c424f278051c3051516b01c632712c7303a3</citedby><cites>FETCH-LOGICAL-c415t-a628971dd1f820dc649aa234b2177c424f278051c3051516b01c632712c7303a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bbrc.2010.02.016$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20138834$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/22202406$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Towata, Tomomi</creatorcontrib><creatorcontrib>Komizu, Yuji</creatorcontrib><creatorcontrib>Suzu, Shinya</creatorcontrib><creatorcontrib>Ueoka, Ryuichi</creatorcontrib><creatorcontrib>Okada, Seiji</creatorcontrib><title>Highly selective fusion and accumulation of hybrid liposomes into primary effusion lymphoma cells along with induction of apoptosis</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>Primary effusion lymphoma (PEL) is an aggressive neoplasm caused by human herpes virus-8 infection, and is generally resistant to chemotherapy. Hybrid liposomes, composed of dimyristoylphosphatidylcholine (DMPC) and polyoxyethylene (21) dodecyl ether (C
12(EO)
21) (HL-21), were rapidly accumulated in the membrane of PEL cells. HL-21 also increased membrane fluidity of PEL cells, and induced caspase-3 activation along with cell death. These results suggest that HL-21 should be an effective and attractive regent for PEL treatment.</description><subject>60 APPLIED LIFE SCIENCES</subject><subject>APOPTOSIS</subject><subject>Caspase-3</subject><subject>Cell Line, Tumor</subject><subject>Cell Membrane - metabolism</subject><subject>CHEMOTHERAPY</subject><subject>DIFFUSION</subject><subject>Dimyristoylphosphatidylcholine - chemistry</subject><subject>Dimyristoylphosphatidylcholine - metabolism</subject><subject>ETHERS</subject><subject>Human herpesvirus 8</subject><subject>HUMAN POPULATIONS</subject><subject>Humans</subject><subject>Hybrid liposome</subject><subject>HYBRIDIZATION</subject><subject>LIPOSOMES</subject><subject>Liposomes - chemistry</subject><subject>Liposomes - metabolism</subject><subject>Lymphoma, Primary Effusion - metabolism</subject><subject>LYMPHOMAS</subject><subject>Membrane Fluidity</subject><subject>Membrane Fusion</subject><subject>PHOSPHOLIPIDS</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Polyethylene Glycols - metabolism</subject><subject>Primary effusion lymphoma</subject><subject>VIRUSES</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1r3DAYhEVpabZp_0APRdBDT96--ljLhl5KaJJCIJcGchOyJMdaZMuV5IQ9549XZjc9thcJhmcG5h2EPhLYEiD11_2266LeUigC0G2RXqENgRYqSoC_RhsAqCvakvsz9C6lPQAhvG7forNiYU3D-AY9X7uHwR9wst7q7B4t7pfkwoTVZLDSehkXr_IqhB4Phy46g72bQwqjTdhNOeA5ulHFA7b9yeoP4zyEUWFtvU9Y-TA94CeXh8KbRb-kqTnMOSSX3qM3vfLJfjj95-ju8sevi-vq5vbq58X3m0pzssuVqmnTCmIM6RsKRte8VYoy3lEihOaU91Q0sCOalWdH6g6IrhkVhGrBgCl2jj4fc0PKTibtstWDDtNUmktKKVAOdaG-HKk5ht-LTVmOLq1N1GTDkmQjxK7ktfBfUjAmypWbtpD0SOoYUoq2l6ejSQJy3VLu5bqlXLeUQGWRiunTKX7pRmv-Wl7GK8C3I2DL0R6djWsnO2lrXFwrmeD-lf8Holqwag</recordid><startdate>20100312</startdate><enddate>20100312</enddate><creator>Towata, Tomomi</creator><creator>Komizu, Yuji</creator><creator>Suzu, Shinya</creator><creator>Ueoka, Ryuichi</creator><creator>Okada, Seiji</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>OTOTI</scope></search><sort><creationdate>20100312</creationdate><title>Highly selective fusion and accumulation of hybrid liposomes into primary effusion lymphoma cells along with induction of apoptosis</title><author>Towata, Tomomi ; Komizu, Yuji ; Suzu, Shinya ; Ueoka, Ryuichi ; Okada, Seiji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-a628971dd1f820dc649aa234b2177c424f278051c3051516b01c632712c7303a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>60 APPLIED LIFE SCIENCES</topic><topic>APOPTOSIS</topic><topic>Caspase-3</topic><topic>Cell Line, Tumor</topic><topic>Cell Membrane - metabolism</topic><topic>CHEMOTHERAPY</topic><topic>DIFFUSION</topic><topic>Dimyristoylphosphatidylcholine - chemistry</topic><topic>Dimyristoylphosphatidylcholine - metabolism</topic><topic>ETHERS</topic><topic>Human herpesvirus 8</topic><topic>HUMAN POPULATIONS</topic><topic>Humans</topic><topic>Hybrid liposome</topic><topic>HYBRIDIZATION</topic><topic>LIPOSOMES</topic><topic>Liposomes - chemistry</topic><topic>Liposomes - metabolism</topic><topic>Lymphoma, Primary Effusion - metabolism</topic><topic>LYMPHOMAS</topic><topic>Membrane Fluidity</topic><topic>Membrane Fusion</topic><topic>PHOSPHOLIPIDS</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Polyethylene Glycols - metabolism</topic><topic>Primary effusion lymphoma</topic><topic>VIRUSES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Towata, Tomomi</creatorcontrib><creatorcontrib>Komizu, Yuji</creatorcontrib><creatorcontrib>Suzu, Shinya</creatorcontrib><creatorcontrib>Ueoka, Ryuichi</creatorcontrib><creatorcontrib>Okada, Seiji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>OSTI.GOV</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Towata, Tomomi</au><au>Komizu, Yuji</au><au>Suzu, Shinya</au><au>Ueoka, Ryuichi</au><au>Okada, Seiji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Highly selective fusion and accumulation of hybrid liposomes into primary effusion lymphoma cells along with induction of apoptosis</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2010-03-12</date><risdate>2010</risdate><volume>393</volume><issue>3</issue><spage>445</spage><epage>448</epage><pages>445-448</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Primary effusion lymphoma (PEL) is an aggressive neoplasm caused by human herpes virus-8 infection, and is generally resistant to chemotherapy. Hybrid liposomes, composed of dimyristoylphosphatidylcholine (DMPC) and polyoxyethylene (21) dodecyl ether (C
12(EO)
21) (HL-21), were rapidly accumulated in the membrane of PEL cells. HL-21 also increased membrane fluidity of PEL cells, and induced caspase-3 activation along with cell death. These results suggest that HL-21 should be an effective and attractive regent for PEL treatment.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>20138834</pmid><doi>10.1016/j.bbrc.2010.02.016</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-291X |
| ispartof | Biochemical and biophysical research communications, 2010-03, Vol.393 (3), p.445-448 |
| issn | 0006-291X 1090-2104 |
| language | eng |
| recordid | cdi_osti_scitechconnect_22202406 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | 60 APPLIED LIFE SCIENCES APOPTOSIS Caspase-3 Cell Line, Tumor Cell Membrane - metabolism CHEMOTHERAPY DIFFUSION Dimyristoylphosphatidylcholine - chemistry Dimyristoylphosphatidylcholine - metabolism ETHERS Human herpesvirus 8 HUMAN POPULATIONS Humans Hybrid liposome HYBRIDIZATION LIPOSOMES Liposomes - chemistry Liposomes - metabolism Lymphoma, Primary Effusion - metabolism LYMPHOMAS Membrane Fluidity Membrane Fusion PHOSPHOLIPIDS Polyethylene Glycols - chemistry Polyethylene Glycols - metabolism Primary effusion lymphoma VIRUSES |
| title | Highly selective fusion and accumulation of hybrid liposomes into primary effusion lymphoma cells along with induction of apoptosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T00%3A07%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_osti_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Highly%20selective%20fusion%20and%20accumulation%20of%20hybrid%20liposomes%20into%20primary%20effusion%20lymphoma%20cells%20along%20with%20induction%20of%20apoptosis&rft.jtitle=Biochemical%20and%20biophysical%20research%20communications&rft.au=Towata,%20Tomomi&rft.date=2010-03-12&rft.volume=393&rft.issue=3&rft.spage=445&rft.epage=448&rft.pages=445-448&rft.issn=0006-291X&rft.eissn=1090-2104&rft_id=info:doi/10.1016/j.bbrc.2010.02.016&rft_dat=%3Cproquest_osti_%3E877573090%3C/proquest_osti_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=733788389&rft_id=info:pmid/20138834&rft_els_id=S0006291X10002160&rfr_iscdi=true |