Static pressure drives proliferation of vascular smooth muscle cells via caveolin-1/ERK1/2 pathway

Intimal hyperplasia plays an important role in various types of vascular remodeling. Mechanical forces derived from blood flow are associated with the proliferation of vascular smooth muscle cells (VSMC). This contributes to many vascular disorders such as hypertension, atherosclerosis and restenosi...

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Veröffentlicht in:	Biochemical and biophysical research communications 2010-01, Vol.391 (4), p.1693-1697
Hauptverfasser:	Luo, Di-xian, Cheng, Jiming, Xiong, Yan, Li, Junmo, Xia, Chenglai, Xu, Canxin, Wang, Chun, Zhu, Bingyang, Hu, Zhuowei, Liao, Duan-fang
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Animals AORTA ARTERIOSCLEROSIS BLOOD FLOW CARBON DIOXIDE Caveolin 1 - genetics Caveolin 1 - metabolism Caveolin-1 CELL PROLIFERATION Extracellular signal-regulated kinase Flavonoids - pharmacology GROWTH FACTORS HYPERTENSION Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - physiology MUSCLES Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - physiology PHOSPHORYLATION PHOSPHOTRANSFERASES Pressure Proliferation Protein Kinase Inhibitors - pharmacology RATS RECEPTORS SIGNALS Static pressure Vascular smooth muscle cell
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