Selective activation of SHP2 activity by cisplatin revealed by a novel chemical probe-based assay

Src homology-2 (SH2) domain-containing phosphatase 2 (SHP2) is known to participate in several different signaling pathways to mediate cell growth, survival, migration, and differentiation. However, due to the lack of proper analytical tools, it is unclear whether the phosphatase activity of SHP2 is...

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Veröffentlicht in:	Biochemical and biophysical research communications 2010-01, Vol.391 (1), p.230-234
Hauptverfasser:	Kuo, Chun-Chen, Chu, Chi-Yuan, Lin, Jing-Jer, Lo, Lee-Chiang
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Activity-based probe ANTIBODIES Antibodies - immunology Antineoplastic Agents - pharmacology Biological Assay Biotin - analogs & derivatives Biotin - chemistry Cell Line, Tumor Chemical probe Cisplatin - pharmacology DNA DAMAGES Enzyme Activation GELS Humans Molecular Probes - chemistry NEOPLASMS Neoplasms - enzymology Organophosphates - chemistry PHOSPHATASES Phosphorylation PROBES Protein tyrosine phosphatase Protein Tyrosine Phosphatase, Non-Receptor Type 11 - biosynthesis Protein Tyrosine Phosphatase, Non-Receptor Type 11 - chemistry Protein Tyrosine Phosphatase, Non-Receptor Type 11 - immunology Protein Tyrosine Phosphatases - metabolism RADIOISOTOPES REAGENTS SHP2 TYROSINE
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