GLP-1 receptor antagonist as a potential probe for pancreatic {beta}-cell imaging

We examined exendin(9-39), an antagonist of glucagon-like peptide-1 (GLP-1) receptor (GLP-1R), as a potential probe for imaging of pancreatic {beta}-cells. To evaluate in vitro receptor specificity, binding assay was performed using dispersed mouse islet cells. Binding assay showed competitive inhib...

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Veröffentlicht in:	Biochemical and biophysical research communications 2009-11, Vol.389 (3)
Hauptverfasser:	Mukai, Eri, Japan Association for the Advancement of Medical Equipment, Tokyo, Toyoda, Kentaro, Kimura, Hiroyuki, Kawashima, Hidekazu, Fujimoto, Hiroyuki, Ueda, Masashi, Temma, Takashi, Hirao, Konomu, Nagakawa, Kenji, Saji, Hideo, Inagaki, Nobuya, CREST of Japan Science and Technology Cooperation
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES FLUORESCENCE GLUCAGON IN VITRO IN VIVO IODINE 125 LUNGS PANCREAS PROBES RADIOACTIVITY RECEPTORS TRANSGENIC MICE
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