Blockade of CD26-mediated T cell costimulation with soluble caveolin-1-Ig fusion protein induces anergy in CD4 +T cells

CD26 binds to caveolin-1 in antigen-presenting cells (APC), and that ligation of CD26 by caveolin-1 induces T cell proliferation in a TCR/CD3-dependent manner. We report herein the effects of CD26–caveolin-1 costimulatory blockade by fusion protein caveolin-1-Ig (Cav-Ig). Soluble Cav-Ig inhibits T c...

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Veröffentlicht in:	Biochemical and biophysical research communications 2009-08, Vol.386 (2), p.327-332
Hauptverfasser:	Ohnuma, Kei, Uchiyama, Masahiko, Hatano, Ryo, Takasawa, Wataru, Endo, Yuko, Dang, Nam H., Morimoto, Chikao
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Anergy ANTIGENS Caveolin 1 - immunology Caveolin-1 Caveolin-1-Ig CD26 CD4-Positive T-Lymphocytes - immunology CELL PROLIFERATION Cells, Cultured Clonal Anergy Costimulation Dipeptidyl Peptidase 4 - immunology Humans Immunoglobulin G - immunology Immunosuppression Lymphocyte Activation PROTEINS Recombinant Fusion Proteins - immunology SIGNALS THERAPY
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Zusammenfassung:	CD26 binds to caveolin-1 in antigen-presenting cells (APC), and that ligation of CD26 by caveolin-1 induces T cell proliferation in a TCR/CD3-dependent manner. We report herein the effects of CD26–caveolin-1 costimulatory blockade by fusion protein caveolin-1-Ig (Cav-Ig). Soluble Cav-Ig inhibits T cell proliferation and cytokine production in response to recall antigen, or allogeneic APC. Our data hence suggest that blocking of CD26-associated signaling by soluble Cav-Ig may be an effective approach as immunosuppressive therapy.
ISSN:	0006-291X 1090-2104
DOI:	10.1016/j.bbrc.2009.06.027