HIC1 interacts with a specific subunit of SWI/SNF complexes, ARID1A/BAF250A

HIC1, a tumor suppressor gene epigenetically silenced in many human cancers encodes a transcriptional repressor involved in regulatory loops modulating p53-dependent and E2F1-dependent cell survival and stress responses. HIC1 is also implicated in growth control since it recruits BRG1, one of the tw...

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Veröffentlicht in:	Biochemical and biophysical research communications 2009-08, Vol.385 (4), p.586-590
Hauptverfasser:	Van Rechem, Capucine, Boulay, Gaylor, Leprince, Dominique
Format:	Artikel
Sprache:	eng
Schlagworte:	17p13.3 60 APPLIED LIFE SCIENCES ARID1A BAF250A BRG1 BTB/POZ Cell Line CHROMATIN Chromatin Immunoprecipitation Down-Regulation E2F1 Transcription Factor - genetics FIBROBLASTS Gene Expression Regulation, Neoplastic GENES HIC1 Humans HYBRIDIZATION Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - metabolism NEOPLASMS Nuclear Proteins - genetics Nuclear Proteins - metabolism Protein Subunits - genetics Protein Subunits - metabolism PROTEINS SCREENING SWI/SNF complexes TRANSCRIPTION Transcription Factors - genetics Transcription Factors - metabolism Transcriptional repression Tumor suppressor genes Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Two-Hybrid System Techniques YEASTS
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