Sifuvirtide, a potent HIV fusion inhibitor peptide

Enfuvirtide (ENF) is currently the only FDA approved HIV fusion inhibitor in clinical use. Searching for more drugs in this category with higher efficacy and lower toxicity seems to be a logical next step. In line with this objective, a synthetic peptide with 36 amino acid residues, called Sifuvirti...

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Veröffentlicht in:	Biochemical and biophysical research communications 2009-05, Vol.382 (3), p.540-544
Hauptverfasser:	Wang, Rui-Rui, Yang, Liu-Meng, Wang, Yun-Hua, Pang, Wei, Tam, Siu-Cheung, Tien, Po, Zheng, Yong-Tang
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES AIDS VIRUS Anti-HIV agents Cell Line COMPARATIVE EVALUATIONS CONCENTRATION RATIO ECOLOGICAL CONCENTRATION Enfuvirtide Fusion inhibitor Glutathione Transferase - chemistry HIV - drug effects HIV - physiology HIV Fusion Inhibitors - pharmacology HIV Fusion Inhibitors - toxicity HIV-1 Human immunodeficiency virus Humans PEPTIDES Peptides - pharmacology Peptides - toxicity Sifuvirtide SOCIO-ECONOMIC FACTORS STRAINS TOXICITY Virus Replication - drug effects
Online-Zugang:	Volltext
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