MR-guided Neurolytic Celiac Plexus Ablation: An Evaluation of Effect and Injection Spread Pattern in Cancer Patients with Celiac Tumor Infiltration
Objective The purpose of this study was to evaluate the feasibility, the initial accuracy, and the effects of the MR-guided neurolytic celiac plexus ablation as a method to treat cancer-induced chronic abdominal pain. Methods Thirteen celiac plexus ablations were performed for 12 patients. A 0.23-T...
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| Veröffentlicht in: | Cardiovascular and interventional radiology 2013-04, Vol.36 (2), p.472-478 |
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| creator | Akural, Etem Ojala, Risto O. Järvimäki, Voitto Kariniemi, Juho Tervonen, Osmo A. Blanco Sequeiros, Roberto |
| description | Objective
The purpose of this study was to evaluate the feasibility, the initial accuracy, and the effects of the MR-guided neurolytic celiac plexus ablation as a method to treat cancer-induced chronic abdominal pain.
Methods
Thirteen celiac plexus ablations were performed for 12 patients. A 0.23-T open MRI scanner with optical navigation was used for procedural guidance. As an adjunct to the MR-guided needle positioning, the needle location was confirmed with saline injection and consequent MR imaging (STIR sequence). The spread of the ablative injection material (alcohol-lidocaine mix) was observed by repeating this sequence after the therapeutic injection. Pain scores from seven patients (eight ablations) were used to assess the therapy effect.
Results
MR guidance allowed adequate needle positioning and visualization of injection material in all cases. The rest pain scores significantly decreased from 4 (median) at baseline to 1 (median) at 2 weeks (
p
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| doi_str_mv | 10.1007/s00270-012-0417-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_osti_</sourceid><recordid>TN_cdi_osti_scitechconnect_22156381</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1317402792</sourcerecordid><originalsourceid>FETCH-LOGICAL-c400t-7654d5d6a54a72c72a5ffeb92742d8371e1c06acdc448caa9e5c49828b57dae63</originalsourceid><addsrcrecordid>eNp1kcFuEzEQhi1ERUPhAbggS1y4LLW99nrDLYpCW6lABUXiZjn2bOtoYwfbS9Pn4IXr7baFCyd7xt_8M-MfoTeUfKCEyONECJOkIpRVhFNZ7Z-hGeV1idrm53M0I1TyigpBD9HLlDaEUNEy8QIdMibalkkxQ38-f6uuBmfB4i8wxNDfZmfwEnqnDb7oYT8kvFj3OrvgP-KFx6vfuh_uQxw6vOo6MBlrb_GZ35TrmP--i6AtvtA5Q_TYebzU3kAcMw58TvjG5evHJpfDNsRS3bk-x3vhV-ig032C1w_nEfrxaXW5PK3Ov56cLRfnleGE5Eo2glthGy24lsxIpkWZZj1nkjPb1pICNaTRxhrOW6P1HITh85a1ayGthqY-Qu8m3ZCyU8m4DObaBO_LHooxKpq6pYV6P1G7GH4NkLLaumSg77WHMCRF6_LLxYc5-yv4hG7CEH3ZYaSacbBGFopOlIkhpQid2kW31fFWUaJGX9Xkqyq-qtFXtS81bx-Uh_UW7FPFo5EFYBOQypO_gvhP6_-q3gEK5a44</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1316274267</pqid></control><display><type>article</type><title>MR-guided Neurolytic Celiac Plexus Ablation: An Evaluation of Effect and Injection Spread Pattern in Cancer Patients with Celiac Tumor Infiltration</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Akural, Etem ; Ojala, Risto O. ; Järvimäki, Voitto ; Kariniemi, Juho ; Tervonen, Osmo A. ; Blanco Sequeiros, Roberto</creator><creatorcontrib>Akural, Etem ; Ojala, Risto O. ; Järvimäki, Voitto ; Kariniemi, Juho ; Tervonen, Osmo A. ; Blanco Sequeiros, Roberto</creatorcontrib><description>Objective
The purpose of this study was to evaluate the feasibility, the initial accuracy, and the effects of the MR-guided neurolytic celiac plexus ablation as a method to treat cancer-induced chronic abdominal pain.
Methods
Thirteen celiac plexus ablations were performed for 12 patients. A 0.23-T open MRI scanner with optical navigation was used for procedural guidance. As an adjunct to the MR-guided needle positioning, the needle location was confirmed with saline injection and consequent MR imaging (STIR sequence). The spread of the ablative injection material (alcohol-lidocaine mix) was observed by repeating this sequence after the therapeutic injection. Pain scores from seven patients (eight ablations) were used to assess the therapy effect.
Results
MR guidance allowed adequate needle positioning and visualization of injection material in all cases. The rest pain scores significantly decreased from 4 (median) at baseline to 1 (median) at 2 weeks (
p
< 0.05). Average and worst pain experienced during the past week were significantly lower at the 2-week time point compared with the baseline (
p
< 0.05). However, the intervention did not result in reduction of opioid use at 2 weeks.
Conclusions
MR guidance is an accurate and safe method for celiac plexus ablation with positive therapeutic effect.</description><identifier>ISSN: 0174-1551</identifier><identifier>EISSN: 1432-086X</identifier><identifier>DOI: 10.1007/s00270-012-0417-x</identifier><identifier>PMID: 22588275</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Abdominal Pain - etiology ; Abdominal Pain - surgery ; ABLATION ; ACCURACY ; Aged ; Aged, 80 and over ; Anesthetics, Local - administration & dosage ; Cardiology ; Catheter Ablation - methods ; Celiac Plexus - pathology ; Clinical Investigation ; Ethanol - administration & dosage ; Female ; Gallbladder Neoplasms - complications ; Humans ; Imaging ; Injections ; Lidocaine - administration & dosage ; Magnetic Resonance Imaging ; Magnetic Resonance Imaging, Interventional ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Needles ; Neoplasm Invasiveness ; NMR IMAGING ; Nuclear Medicine ; PAIN ; Pain Management - methods ; Pain Measurement ; Pancreatic Neoplasms - complications ; PATIENTS ; Prospective Studies ; Radiology ; RADIOLOGY AND NUCLEAR MEDICINE ; REDUCTION ; THERAPY ; Tomography, X-Ray Computed ; Treatment Outcome ; Ultrasound</subject><ispartof>Cardiovascular and interventional radiology, 2013-04, Vol.36 (2), p.472-478</ispartof><rights>Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2012</rights><rights>Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-7654d5d6a54a72c72a5ffeb92742d8371e1c06acdc448caa9e5c49828b57dae63</citedby><cites>FETCH-LOGICAL-c400t-7654d5d6a54a72c72a5ffeb92742d8371e1c06acdc448caa9e5c49828b57dae63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00270-012-0417-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00270-012-0417-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22588275$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/22156381$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Akural, Etem</creatorcontrib><creatorcontrib>Ojala, Risto O.</creatorcontrib><creatorcontrib>Järvimäki, Voitto</creatorcontrib><creatorcontrib>Kariniemi, Juho</creatorcontrib><creatorcontrib>Tervonen, Osmo A.</creatorcontrib><creatorcontrib>Blanco Sequeiros, Roberto</creatorcontrib><title>MR-guided Neurolytic Celiac Plexus Ablation: An Evaluation of Effect and Injection Spread Pattern in Cancer Patients with Celiac Tumor Infiltration</title><title>Cardiovascular and interventional radiology</title><addtitle>Cardiovasc Intervent Radiol</addtitle><addtitle>Cardiovasc Intervent Radiol</addtitle><description>Objective
The purpose of this study was to evaluate the feasibility, the initial accuracy, and the effects of the MR-guided neurolytic celiac plexus ablation as a method to treat cancer-induced chronic abdominal pain.
Methods
Thirteen celiac plexus ablations were performed for 12 patients. A 0.23-T open MRI scanner with optical navigation was used for procedural guidance. As an adjunct to the MR-guided needle positioning, the needle location was confirmed with saline injection and consequent MR imaging (STIR sequence). The spread of the ablative injection material (alcohol-lidocaine mix) was observed by repeating this sequence after the therapeutic injection. Pain scores from seven patients (eight ablations) were used to assess the therapy effect.
Results
MR guidance allowed adequate needle positioning and visualization of injection material in all cases. The rest pain scores significantly decreased from 4 (median) at baseline to 1 (median) at 2 weeks (
p
< 0.05). Average and worst pain experienced during the past week were significantly lower at the 2-week time point compared with the baseline (
p
< 0.05). However, the intervention did not result in reduction of opioid use at 2 weeks.
Conclusions
MR guidance is an accurate and safe method for celiac plexus ablation with positive therapeutic effect.</description><subject>Abdominal Pain - etiology</subject><subject>Abdominal Pain - surgery</subject><subject>ABLATION</subject><subject>ACCURACY</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anesthetics, Local - administration & dosage</subject><subject>Cardiology</subject><subject>Catheter Ablation - methods</subject><subject>Celiac Plexus - pathology</subject><subject>Clinical Investigation</subject><subject>Ethanol - administration & dosage</subject><subject>Female</subject><subject>Gallbladder Neoplasms - complications</subject><subject>Humans</subject><subject>Imaging</subject><subject>Injections</subject><subject>Lidocaine - administration & dosage</subject><subject>Magnetic Resonance Imaging</subject><subject>Magnetic Resonance Imaging, Interventional</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Needles</subject><subject>Neoplasm Invasiveness</subject><subject>NMR IMAGING</subject><subject>Nuclear Medicine</subject><subject>PAIN</subject><subject>Pain Management - methods</subject><subject>Pain Measurement</subject><subject>Pancreatic Neoplasms - complications</subject><subject>PATIENTS</subject><subject>Prospective Studies</subject><subject>Radiology</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>REDUCTION</subject><subject>THERAPY</subject><subject>Tomography, X-Ray Computed</subject><subject>Treatment Outcome</subject><subject>Ultrasound</subject><issn>0174-1551</issn><issn>1432-086X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kcFuEzEQhi1ERUPhAbggS1y4LLW99nrDLYpCW6lABUXiZjn2bOtoYwfbS9Pn4IXr7baFCyd7xt_8M-MfoTeUfKCEyONECJOkIpRVhFNZ7Z-hGeV1idrm53M0I1TyigpBD9HLlDaEUNEy8QIdMibalkkxQ38-f6uuBmfB4i8wxNDfZmfwEnqnDb7oYT8kvFj3OrvgP-KFx6vfuh_uQxw6vOo6MBlrb_GZ35TrmP--i6AtvtA5Q_TYebzU3kAcMw58TvjG5evHJpfDNsRS3bk-x3vhV-ig032C1w_nEfrxaXW5PK3Ov56cLRfnleGE5Eo2glthGy24lsxIpkWZZj1nkjPb1pICNaTRxhrOW6P1HITh85a1ayGthqY-Qu8m3ZCyU8m4DObaBO_LHooxKpq6pYV6P1G7GH4NkLLaumSg77WHMCRF6_LLxYc5-yv4hG7CEH3ZYaSacbBGFopOlIkhpQid2kW31fFWUaJGX9Xkqyq-qtFXtS81bx-Uh_UW7FPFo5EFYBOQypO_gvhP6_-q3gEK5a44</recordid><startdate>20130401</startdate><enddate>20130401</enddate><creator>Akural, Etem</creator><creator>Ojala, Risto O.</creator><creator>Järvimäki, Voitto</creator><creator>Kariniemi, Juho</creator><creator>Tervonen, Osmo A.</creator><creator>Blanco Sequeiros, Roberto</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>20130401</creationdate><title>MR-guided Neurolytic Celiac Plexus Ablation: An Evaluation of Effect and Injection Spread Pattern in Cancer Patients with Celiac Tumor Infiltration</title><author>Akural, Etem ; Ojala, Risto O. ; Järvimäki, Voitto ; Kariniemi, Juho ; Tervonen, Osmo A. ; Blanco Sequeiros, Roberto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-7654d5d6a54a72c72a5ffeb92742d8371e1c06acdc448caa9e5c49828b57dae63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Abdominal Pain - etiology</topic><topic>Abdominal Pain - surgery</topic><topic>ABLATION</topic><topic>ACCURACY</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anesthetics, Local - administration & dosage</topic><topic>Cardiology</topic><topic>Catheter Ablation - methods</topic><topic>Celiac Plexus - pathology</topic><topic>Clinical Investigation</topic><topic>Ethanol - administration & dosage</topic><topic>Female</topic><topic>Gallbladder Neoplasms - complications</topic><topic>Humans</topic><topic>Imaging</topic><topic>Injections</topic><topic>Lidocaine - administration & dosage</topic><topic>Magnetic Resonance Imaging</topic><topic>Magnetic Resonance Imaging, Interventional</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Needles</topic><topic>Neoplasm Invasiveness</topic><topic>NMR IMAGING</topic><topic>Nuclear Medicine</topic><topic>PAIN</topic><topic>Pain Management - methods</topic><topic>Pain Measurement</topic><topic>Pancreatic Neoplasms - complications</topic><topic>PATIENTS</topic><topic>Prospective Studies</topic><topic>Radiology</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>REDUCTION</topic><topic>THERAPY</topic><topic>Tomography, X-Ray Computed</topic><topic>Treatment Outcome</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akural, Etem</creatorcontrib><creatorcontrib>Ojala, Risto O.</creatorcontrib><creatorcontrib>Järvimäki, Voitto</creatorcontrib><creatorcontrib>Kariniemi, Juho</creatorcontrib><creatorcontrib>Tervonen, Osmo A.</creatorcontrib><creatorcontrib>Blanco Sequeiros, Roberto</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Cardiovascular and interventional radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akural, Etem</au><au>Ojala, Risto O.</au><au>Järvimäki, Voitto</au><au>Kariniemi, Juho</au><au>Tervonen, Osmo A.</au><au>Blanco Sequeiros, Roberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MR-guided Neurolytic Celiac Plexus Ablation: An Evaluation of Effect and Injection Spread Pattern in Cancer Patients with Celiac Tumor Infiltration</atitle><jtitle>Cardiovascular and interventional radiology</jtitle><stitle>Cardiovasc Intervent Radiol</stitle><addtitle>Cardiovasc Intervent Radiol</addtitle><date>2013-04-01</date><risdate>2013</risdate><volume>36</volume><issue>2</issue><spage>472</spage><epage>478</epage><pages>472-478</pages><issn>0174-1551</issn><eissn>1432-086X</eissn><abstract>Objective
The purpose of this study was to evaluate the feasibility, the initial accuracy, and the effects of the MR-guided neurolytic celiac plexus ablation as a method to treat cancer-induced chronic abdominal pain.
Methods
Thirteen celiac plexus ablations were performed for 12 patients. A 0.23-T open MRI scanner with optical navigation was used for procedural guidance. As an adjunct to the MR-guided needle positioning, the needle location was confirmed with saline injection and consequent MR imaging (STIR sequence). The spread of the ablative injection material (alcohol-lidocaine mix) was observed by repeating this sequence after the therapeutic injection. Pain scores from seven patients (eight ablations) were used to assess the therapy effect.
Results
MR guidance allowed adequate needle positioning and visualization of injection material in all cases. The rest pain scores significantly decreased from 4 (median) at baseline to 1 (median) at 2 weeks (
p
< 0.05). Average and worst pain experienced during the past week were significantly lower at the 2-week time point compared with the baseline (
p
< 0.05). However, the intervention did not result in reduction of opioid use at 2 weeks.
Conclusions
MR guidance is an accurate and safe method for celiac plexus ablation with positive therapeutic effect.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>22588275</pmid><doi>10.1007/s00270-012-0417-x</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0174-1551 |
| ispartof | Cardiovascular and interventional radiology, 2013-04, Vol.36 (2), p.472-478 |
| issn | 0174-1551 1432-086X |
| language | eng |
| recordid | cdi_osti_scitechconnect_22156381 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Abdominal Pain - etiology Abdominal Pain - surgery ABLATION ACCURACY Aged Aged, 80 and over Anesthetics, Local - administration & dosage Cardiology Catheter Ablation - methods Celiac Plexus - pathology Clinical Investigation Ethanol - administration & dosage Female Gallbladder Neoplasms - complications Humans Imaging Injections Lidocaine - administration & dosage Magnetic Resonance Imaging Magnetic Resonance Imaging, Interventional Male Medicine Medicine & Public Health Middle Aged Needles Neoplasm Invasiveness NMR IMAGING Nuclear Medicine PAIN Pain Management - methods Pain Measurement Pancreatic Neoplasms - complications PATIENTS Prospective Studies Radiology RADIOLOGY AND NUCLEAR MEDICINE REDUCTION THERAPY Tomography, X-Ray Computed Treatment Outcome Ultrasound |
| title | MR-guided Neurolytic Celiac Plexus Ablation: An Evaluation of Effect and Injection Spread Pattern in Cancer Patients with Celiac Tumor Infiltration |
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