Mitigation and Treatment of Radiation-Induced Thoracic Injury With a Cyclooxygenase-2 Inhibitor, Celecoxib

Purpose To test whether a cyclooxygenase-2 inhibitor (celecoxib) could reduce mortality resulting from radiation-induced pneumonitis. Methods and Materials Celecoxib was given to mice twice daily for 40 consecutive days starting on the day of local thoracic irradiation (LTI) or 40 or 80 days later....

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2013-02, Vol.85 (2), p.472-476
Hauptverfasser:	Hunter, Nancy R., MS, Valdecanas, David, BS, Liao, Zhongxing, MD, Milas, Luka, MD, Thames, Howard D., PhD, Mason, Kathy A., MS
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Celecoxib CLINICAL TRIALS Confidence Intervals Cyclooxygenase 2 Inhibitors - administration & dosage DEATH DISEASE INCIDENCE Dose-Response Relationship, Radiation Drug Administration Schedule Female HEALTH HAZARDS Hematology, Oncology and Palliative Medicine IRRADIATION Lethal Dose 50 LETHAL DOSES LUNGS MICE Mice, Inbred C3H MORTALITY NEOPLASMS PNEUMONITIS Proportional Hazards Models Pyrazoles - administration & dosage RADIATION INJURIES Radiation Pneumonitis - mortality Radiation Pneumonitis - prevention & control Radiology RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY Sulfonamides - administration & dosage Time-to-Treatment TOXICITY
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!