MGMT Gene Promoter Methylation as a Potent Prognostic Factor in Glioblastoma Treated With Temozolomide-Based Chemoradiotherapy: A Single-Institution Study

Purpose Recently, cells deficient in O6 -methylguanine–DNA methyltransferase (MGMT) were found to show increased sensitivity to temozolomide (TMZ). We evaluated whether hypermethylation of MGMT was associated with survival in patients with glioblastoma multiforme (GBM). Methods and Materials We retr...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2012-11, Vol.84 (3), p.661-667
Hauptverfasser:	Kim, Young Suk, M.D, Kim, Se Hoon, M.D., Ph.D, Cho, Jaeho, M.D., Ph.D, Kim, Jun Won, M.D, Chang, Jong Hee, M.D., Ph.D, Kim, Dong Suk, M.D., Ph.D, Lee, Kyu Sung, M.D., Ph.D, Suh, Chang-Ok, M.D., Ph.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Aged Antineoplastic Agents, Alkylating - therapeutic use Biological and medical sciences Brain Neoplasms - genetics Brain Neoplasms - mortality Brain Neoplasms - therapy COMBINED THERAPY Dacarbazine - analogs & derivatives Dacarbazine - therapeutic use Disease-Free Survival DNA DNA Methylation DNA Modification Methylases - genetics DNA Modification Methylases - metabolism DNA Repair Enzymes - genetics DNA Repair Enzymes - metabolism Female GENES Glioblastoma Glioblastoma - genetics Glioblastoma - mortality Glioblastoma - therapy GLIOMAS Hematology, Oncology and Palliative Medicine Humans Male Medical sciences METHYL TRANSFERASES Methylation Middle Aged MULTIVARIATE ANALYSIS Neurology O6-methylguanine-DNA methyltransferase PATIENTS Prognosis Prognostic factor Promoter Regions, Genetic - genetics RADIATION DOSES Radiology RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY Radiotherapy, Conformal Reoperation Retrospective Studies SENSITIVITY SURGERY Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Tumors of the nervous system. Phacomatoses
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