Prognostic Value of Subclassification Using MRI in the T4 Classification Nasopharyngeal Carcinoma Intensity-Modulated Radiotherapy Treatment
Purpose To subclassify patients with the T4 classification nasopharyngeal carcinoma (NPC), according to the seventh edition of the American Joint Committee on Cancer staging system, using magnetic resonance imaging (MRI), and to evaluate the prognostic value of subclassification after intensity-modu...
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| creator | Chen, Lei, M.D Liu, Li-Zhi, M.D Chen, Mo, M.D Li, Wen-Fei, M.D Yin, Wen-Jing, M.D Lin, Ai-Hua, M.D., Ph.D Sun, Ying, M.D., Ph.D Li, Li, M.D., Ph.D Ma, Jun, M.D |
| description | Purpose To subclassify patients with the T4 classification nasopharyngeal carcinoma (NPC), according to the seventh edition of the American Joint Committee on Cancer staging system, using magnetic resonance imaging (MRI), and to evaluate the prognostic value of subclassification after intensity-modulated radiotherapy (IMRT). Methods and Materials A total of 140 patients who underwent MRI and were subsequently histologically diagnosed with nondisseminated classification T4 NPC received IMRT as their primary treatment and were included in this retrospective study. T4 patients were subclassified into two grades: T4a was defined as a primary nasopharyngeal tumor with involvement of the masticator space only; and T4b was defined as involvement of the intracranial region, cranial nerves, and/or orbit. Results The 5-year overall survival (OS) rate and distant metastasis-free survival (DMFS) rate for T4a patients (82.5% and 87.0%, respectively), were significantly higher than for T4b patients (62.6% and 66.8%; p = 0.033 and p = 0.036, respectively). The T4a/b subclassification was an independent prognostic factor for OS (hazard ratio = 2.331, p = 0.032) and DMFS (hazard ratio = 2.602, p = 0.034), and had no significant effect on local relapse-free survival. Conclusions Subclassification of T4 patients, as T4a or T4b, using MRI according to the site of invasion, has prognostic value for the outcomes of IMRT treatment in NPC. |
| doi_str_mv | 10.1016/j.ijrobp.2011.11.021 |
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| fullrecord | <record><control><sourceid>proquest_osti_</sourceid><recordid>TN_cdi_osti_scitechconnect_22149468</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0360301611035097</els_id><sourcerecordid>1687662113</sourcerecordid><originalsourceid>FETCH-LOGICAL-c574t-856ef0c5b7b13604706d26d524c7d190073b2d78ab432e089f29ed8b9493f2743</originalsourceid><addsrcrecordid>eNqFkl2LEzEUhgdR3O7qPxAJiODN1HzNZOZGkOJHYVdltyvehUxypk2dJjXJLPQ_-KPN0KrozcKBc_OcN3nPe4riGcFzgkn9eju32-C7_ZxiQua5MCUPihlpRFuyqvr2sJhhVuOSZfisOI9xi3EmBX9cnFHKMK7qdlb8_BL82vmYrEZf1TAC8j26GTs9qBhtb7VK1jt0G61bo6vrJbIOpQ2gFUeLf5FPKvr9RoWDW4Ma0EIFbZ3fKbR0CVy06VBeeTMOKoFB18pYn3WC2h_QKoBKO3DpSfGoV0OEp6d-Udy-f7dafCwvP39YLt5elroSPJVNVUOPddWJjmSHXODa0NpUlGthSIuxYB01olEdZxRw0_a0BdN0LW9ZTwVnF8WLo-7kW0ZtE-iN9s6BTpJSwlteN5l6daT2wf8YISa5s1HDMCgHfoyS1I2oa0oIux_FjFeECT6p8iOqg48xQC_3we7y2jIkp2DlVh6DlVOwMlcONo89P70wdjswf4Z-J5mBlydARa2GPiinbfzL1YxyykXm3hw5yAu-sxAm_-A0GBsm-8bb-37yv4AerMtXMHyHA8StH4PL4UkiI5VY3kxHON0gyUuocCvYLxai1-8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1034513748</pqid></control><display><type>article</type><title>Prognostic Value of Subclassification Using MRI in the T4 Classification Nasopharyngeal Carcinoma Intensity-Modulated Radiotherapy Treatment</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Chen, Lei, M.D ; Liu, Li-Zhi, M.D ; Chen, Mo, M.D ; Li, Wen-Fei, M.D ; Yin, Wen-Jing, M.D ; Lin, Ai-Hua, M.D., Ph.D ; Sun, Ying, M.D., Ph.D ; Li, Li, M.D., Ph.D ; Ma, Jun, M.D</creator><creatorcontrib>Chen, Lei, M.D ; Liu, Li-Zhi, M.D ; Chen, Mo, M.D ; Li, Wen-Fei, M.D ; Yin, Wen-Jing, M.D ; Lin, Ai-Hua, M.D., Ph.D ; Sun, Ying, M.D., Ph.D ; Li, Li, M.D., Ph.D ; Ma, Jun, M.D</creatorcontrib><description>Purpose To subclassify patients with the T4 classification nasopharyngeal carcinoma (NPC), according to the seventh edition of the American Joint Committee on Cancer staging system, using magnetic resonance imaging (MRI), and to evaluate the prognostic value of subclassification after intensity-modulated radiotherapy (IMRT). Methods and Materials A total of 140 patients who underwent MRI and were subsequently histologically diagnosed with nondisseminated classification T4 NPC received IMRT as their primary treatment and were included in this retrospective study. T4 patients were subclassified into two grades: T4a was defined as a primary nasopharyngeal tumor with involvement of the masticator space only; and T4b was defined as involvement of the intracranial region, cranial nerves, and/or orbit. Results The 5-year overall survival (OS) rate and distant metastasis-free survival (DMFS) rate for T4a patients (82.5% and 87.0%, respectively), were significantly higher than for T4b patients (62.6% and 66.8%; p = 0.033 and p = 0.036, respectively). The T4a/b subclassification was an independent prognostic factor for OS (hazard ratio = 2.331, p = 0.032) and DMFS (hazard ratio = 2.602, p = 0.034), and had no significant effect on local relapse-free survival. Conclusions Subclassification of T4 patients, as T4a or T4b, using MRI according to the site of invasion, has prognostic value for the outcomes of IMRT treatment in NPC.</description><identifier>ISSN: 0360-3016</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/j.ijrobp.2011.11.021</identifier><identifier>PMID: 22300569</identifier><identifier>CODEN: IOBPD3</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Analysis of Variance ; Biological and medical sciences ; CARCINOMAS ; Chemoradiotherapy - methods ; Chemotherapy, Adjuvant - methods ; CLASSIFICATION ; Female ; HEALTH HAZARDS ; Hematology, Oncology and Palliative Medicine ; Humans ; Karnofsky Performance Status ; Magnetic Resonance Imaging ; Male ; Medical sciences ; METASTASES ; Middle Aged ; Nasopharyngeal carcinoma ; Nasopharyngeal Neoplasms - classification ; Nasopharyngeal Neoplasms - drug therapy ; Nasopharyngeal Neoplasms - mortality ; Nasopharyngeal Neoplasms - pathology ; Nasopharyngeal Neoplasms - radiotherapy ; Neoplasm Invasiveness ; Neoplasm Staging ; NERVES ; NMR IMAGING ; Otorhinolaryngology. Stomatology ; PATIENTS ; Prognosis ; Prognostic value ; Radiology ; RADIOLOGY AND NUCLEAR MEDICINE ; RADIOTHERAPY ; Radiotherapy, Intensity-Modulated ; Subclassification ; T4 classification ; The seventh edition of American Joint Committee on Cancer staging system ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology ; Young Adult</subject><ispartof>International journal of radiation oncology, biology, physics, 2012-09, Vol.84 (1), p.196-202</ispartof><rights>Elsevier Inc.</rights><rights>2012 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c574t-856ef0c5b7b13604706d26d524c7d190073b2d78ab432e089f29ed8b9493f2743</citedby><cites>FETCH-LOGICAL-c574t-856ef0c5b7b13604706d26d524c7d190073b2d78ab432e089f29ed8b9493f2743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijrobp.2011.11.021$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26324247$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22300569$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/22149468$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Lei, M.D</creatorcontrib><creatorcontrib>Liu, Li-Zhi, M.D</creatorcontrib><creatorcontrib>Chen, Mo, M.D</creatorcontrib><creatorcontrib>Li, Wen-Fei, M.D</creatorcontrib><creatorcontrib>Yin, Wen-Jing, M.D</creatorcontrib><creatorcontrib>Lin, Ai-Hua, M.D., Ph.D</creatorcontrib><creatorcontrib>Sun, Ying, M.D., Ph.D</creatorcontrib><creatorcontrib>Li, Li, M.D., Ph.D</creatorcontrib><creatorcontrib>Ma, Jun, M.D</creatorcontrib><title>Prognostic Value of Subclassification Using MRI in the T4 Classification Nasopharyngeal Carcinoma Intensity-Modulated Radiotherapy Treatment</title><title>International journal of radiation oncology, biology, physics</title><addtitle>Int J Radiat Oncol Biol Phys</addtitle><description>Purpose To subclassify patients with the T4 classification nasopharyngeal carcinoma (NPC), according to the seventh edition of the American Joint Committee on Cancer staging system, using magnetic resonance imaging (MRI), and to evaluate the prognostic value of subclassification after intensity-modulated radiotherapy (IMRT). Methods and Materials A total of 140 patients who underwent MRI and were subsequently histologically diagnosed with nondisseminated classification T4 NPC received IMRT as their primary treatment and were included in this retrospective study. T4 patients were subclassified into two grades: T4a was defined as a primary nasopharyngeal tumor with involvement of the masticator space only; and T4b was defined as involvement of the intracranial region, cranial nerves, and/or orbit. Results The 5-year overall survival (OS) rate and distant metastasis-free survival (DMFS) rate for T4a patients (82.5% and 87.0%, respectively), were significantly higher than for T4b patients (62.6% and 66.8%; p = 0.033 and p = 0.036, respectively). The T4a/b subclassification was an independent prognostic factor for OS (hazard ratio = 2.331, p = 0.032) and DMFS (hazard ratio = 2.602, p = 0.034), and had no significant effect on local relapse-free survival. Conclusions Subclassification of T4 patients, as T4a or T4b, using MRI according to the site of invasion, has prognostic value for the outcomes of IMRT treatment in NPC.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>CARCINOMAS</subject><subject>Chemoradiotherapy - methods</subject><subject>Chemotherapy, Adjuvant - methods</subject><subject>CLASSIFICATION</subject><subject>Female</subject><subject>HEALTH HAZARDS</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Karnofsky Performance Status</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>METASTASES</subject><subject>Middle Aged</subject><subject>Nasopharyngeal carcinoma</subject><subject>Nasopharyngeal Neoplasms - classification</subject><subject>Nasopharyngeal Neoplasms - drug therapy</subject><subject>Nasopharyngeal Neoplasms - mortality</subject><subject>Nasopharyngeal Neoplasms - pathology</subject><subject>Nasopharyngeal Neoplasms - radiotherapy</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>NERVES</subject><subject>NMR IMAGING</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>PATIENTS</subject><subject>Prognosis</subject><subject>Prognostic value</subject><subject>Radiology</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>RADIOTHERAPY</subject><subject>Radiotherapy, Intensity-Modulated</subject><subject>Subclassification</subject><subject>T4 classification</subject><subject>The seventh edition of American Joint Committee on Cancer staging system</subject><subject>Tumors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><subject>Young Adult</subject><issn>0360-3016</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkl2LEzEUhgdR3O7qPxAJiODN1HzNZOZGkOJHYVdltyvehUxypk2dJjXJLPQ_-KPN0KrozcKBc_OcN3nPe4riGcFzgkn9eju32-C7_ZxiQua5MCUPihlpRFuyqvr2sJhhVuOSZfisOI9xi3EmBX9cnFHKMK7qdlb8_BL82vmYrEZf1TAC8j26GTs9qBhtb7VK1jt0G61bo6vrJbIOpQ2gFUeLf5FPKvr9RoWDW4Ma0EIFbZ3fKbR0CVy06VBeeTMOKoFB18pYn3WC2h_QKoBKO3DpSfGoV0OEp6d-Udy-f7dafCwvP39YLt5elroSPJVNVUOPddWJjmSHXODa0NpUlGthSIuxYB01olEdZxRw0_a0BdN0LW9ZTwVnF8WLo-7kW0ZtE-iN9s6BTpJSwlteN5l6daT2wf8YISa5s1HDMCgHfoyS1I2oa0oIux_FjFeECT6p8iOqg48xQC_3we7y2jIkp2DlVh6DlVOwMlcONo89P70wdjswf4Z-J5mBlydARa2GPiinbfzL1YxyykXm3hw5yAu-sxAm_-A0GBsm-8bb-37yv4AerMtXMHyHA8StH4PL4UkiI5VY3kxHON0gyUuocCvYLxai1-8</recordid><startdate>20120901</startdate><enddate>20120901</enddate><creator>Chen, Lei, M.D</creator><creator>Liu, Li-Zhi, M.D</creator><creator>Chen, Mo, M.D</creator><creator>Li, Wen-Fei, M.D</creator><creator>Yin, Wen-Jing, M.D</creator><creator>Lin, Ai-Hua, M.D., Ph.D</creator><creator>Sun, Ying, M.D., Ph.D</creator><creator>Li, Li, M.D., Ph.D</creator><creator>Ma, Jun, M.D</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U7</scope><scope>C1K</scope><scope>OTOTI</scope></search><sort><creationdate>20120901</creationdate><title>Prognostic Value of Subclassification Using MRI in the T4 Classification Nasopharyngeal Carcinoma Intensity-Modulated Radiotherapy Treatment</title><author>Chen, Lei, M.D ; Liu, Li-Zhi, M.D ; Chen, Mo, M.D ; Li, Wen-Fei, M.D ; Yin, Wen-Jing, M.D ; Lin, Ai-Hua, M.D., Ph.D ; Sun, Ying, M.D., Ph.D ; Li, Li, M.D., Ph.D ; Ma, Jun, M.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c574t-856ef0c5b7b13604706d26d524c7d190073b2d78ab432e089f29ed8b9493f2743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>CARCINOMAS</topic><topic>Chemoradiotherapy - methods</topic><topic>Chemotherapy, Adjuvant - methods</topic><topic>CLASSIFICATION</topic><topic>Female</topic><topic>HEALTH HAZARDS</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Karnofsky Performance Status</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>METASTASES</topic><topic>Middle Aged</topic><topic>Nasopharyngeal carcinoma</topic><topic>Nasopharyngeal Neoplasms - classification</topic><topic>Nasopharyngeal Neoplasms - drug therapy</topic><topic>Nasopharyngeal Neoplasms - mortality</topic><topic>Nasopharyngeal Neoplasms - pathology</topic><topic>Nasopharyngeal Neoplasms - radiotherapy</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging</topic><topic>NERVES</topic><topic>NMR IMAGING</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>PATIENTS</topic><topic>Prognosis</topic><topic>Prognostic value</topic><topic>Radiology</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>RADIOTHERAPY</topic><topic>Radiotherapy, Intensity-Modulated</topic><topic>Subclassification</topic><topic>T4 classification</topic><topic>The seventh edition of American Joint Committee on Cancer staging system</topic><topic>Tumors</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Lei, M.D</creatorcontrib><creatorcontrib>Liu, Li-Zhi, M.D</creatorcontrib><creatorcontrib>Chen, Mo, M.D</creatorcontrib><creatorcontrib>Li, Wen-Fei, M.D</creatorcontrib><creatorcontrib>Yin, Wen-Jing, M.D</creatorcontrib><creatorcontrib>Lin, Ai-Hua, M.D., Ph.D</creatorcontrib><creatorcontrib>Sun, Ying, M.D., Ph.D</creatorcontrib><creatorcontrib>Li, Li, M.D., Ph.D</creatorcontrib><creatorcontrib>Ma, Jun, M.D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>OSTI.GOV</collection><jtitle>International journal of radiation oncology, biology, physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Lei, M.D</au><au>Liu, Li-Zhi, M.D</au><au>Chen, Mo, M.D</au><au>Li, Wen-Fei, M.D</au><au>Yin, Wen-Jing, M.D</au><au>Lin, Ai-Hua, M.D., Ph.D</au><au>Sun, Ying, M.D., Ph.D</au><au>Li, Li, M.D., Ph.D</au><au>Ma, Jun, M.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic Value of Subclassification Using MRI in the T4 Classification Nasopharyngeal Carcinoma Intensity-Modulated Radiotherapy Treatment</atitle><jtitle>International journal of radiation oncology, biology, physics</jtitle><addtitle>Int J Radiat Oncol Biol Phys</addtitle><date>2012-09-01</date><risdate>2012</risdate><volume>84</volume><issue>1</issue><spage>196</spage><epage>202</epage><pages>196-202</pages><issn>0360-3016</issn><eissn>1879-355X</eissn><coden>IOBPD3</coden><abstract>Purpose To subclassify patients with the T4 classification nasopharyngeal carcinoma (NPC), according to the seventh edition of the American Joint Committee on Cancer staging system, using magnetic resonance imaging (MRI), and to evaluate the prognostic value of subclassification after intensity-modulated radiotherapy (IMRT). Methods and Materials A total of 140 patients who underwent MRI and were subsequently histologically diagnosed with nondisseminated classification T4 NPC received IMRT as their primary treatment and were included in this retrospective study. T4 patients were subclassified into two grades: T4a was defined as a primary nasopharyngeal tumor with involvement of the masticator space only; and T4b was defined as involvement of the intracranial region, cranial nerves, and/or orbit. Results The 5-year overall survival (OS) rate and distant metastasis-free survival (DMFS) rate for T4a patients (82.5% and 87.0%, respectively), were significantly higher than for T4b patients (62.6% and 66.8%; p = 0.033 and p = 0.036, respectively). The T4a/b subclassification was an independent prognostic factor for OS (hazard ratio = 2.331, p = 0.032) and DMFS (hazard ratio = 2.602, p = 0.034), and had no significant effect on local relapse-free survival. Conclusions Subclassification of T4 patients, as T4a or T4b, using MRI according to the site of invasion, has prognostic value for the outcomes of IMRT treatment in NPC.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>22300569</pmid><doi>10.1016/j.ijrobp.2011.11.021</doi><tpages>7</tpages></addata></record> |
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| ispartof | International journal of radiation oncology, biology, physics, 2012-09, Vol.84 (1), p.196-202 |
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| subjects | Adolescent Adult Aged Analysis of Variance Biological and medical sciences CARCINOMAS Chemoradiotherapy - methods Chemotherapy, Adjuvant - methods CLASSIFICATION Female HEALTH HAZARDS Hematology, Oncology and Palliative Medicine Humans Karnofsky Performance Status Magnetic Resonance Imaging Male Medical sciences METASTASES Middle Aged Nasopharyngeal carcinoma Nasopharyngeal Neoplasms - classification Nasopharyngeal Neoplasms - drug therapy Nasopharyngeal Neoplasms - mortality Nasopharyngeal Neoplasms - pathology Nasopharyngeal Neoplasms - radiotherapy Neoplasm Invasiveness Neoplasm Staging NERVES NMR IMAGING Otorhinolaryngology. Stomatology PATIENTS Prognosis Prognostic value Radiology RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY Radiotherapy, Intensity-Modulated Subclassification T4 classification The seventh edition of American Joint Committee on Cancer staging system Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology Young Adult |
| title | Prognostic Value of Subclassification Using MRI in the T4 Classification Nasopharyngeal Carcinoma Intensity-Modulated Radiotherapy Treatment |
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