Direct speciation analysis of arsenic in sub-cellular compartments using micro-X-ray absorption spectroscopy

Identification of arsenic chemical species at a sub-cellular level is a key to understanding the mechanisms involved in arsenic toxicology and antitumor pharmacology. When performed with a microbeam, X-ray absorption near-edge structure (μ-XANES) enables the direct speciation analysis of arsenic in...

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Veröffentlicht in:	Environmental research 2010-07, Vol.110 (5), p.413-416
Hauptverfasser:	Bacquart, Thomas, Devès, Guillaume, Ortega, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ABSORPTION SPECTROSCOPY Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Antineoplastic Agents - toxicity ARSENATES ARSENIC Arsenic - chemistry Arsenic - metabolism Arsenic - toxicity ARSENIC OXIDES Arsenicals - chemistry Arsenicals - metabolism Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Cell Cell Line, Tumor Cellular Chemical agents Chemical and industrial products toxicology. Toxic occupational diseases Compartments Exposure Focusing Hep G2 Cells Humans Intracellular Space - drug effects Intracellular Space - metabolism Medical sciences Metals and various inorganic compounds Microorganisms MICROSCOPY MITOCHONDRIA NEOPLASMS Organelles Organelles - metabolism OXIDATION Oxides - chemistry Oxides - metabolism Oxides - toxicity PH VALUE SPATIAL RESOLUTION Speciation Synchrotron SYNCHROTRONS Toxicology Tumors X RADIATION X-Ray Absorption Spectroscopy X-RAY SPECTROSCOPY X-rays
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