Biological cell irradiation at ultrahigh dose rate employing laser driven protons
The ultrashort duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at...
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| creator | Doria, D. Kakolee, K. F. Kar, S. School of Physics and Astronomy, University of Birmingham, B15 2TT |
| description | The ultrashort duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 10{sup 9}Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4{+-}0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source. |
| doi_str_mv | 10.1063/1.4736777 |
| format | Conference Proceeding |
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F. ; Kar, S. ; School of Physics and Astronomy, University of Birmingham, B15 2TT</creator><creatorcontrib>Doria, D. ; Kakolee, K. F. ; Kar, S. ; School of Physics and Astronomy, University of Birmingham, B15 2TT</creatorcontrib><description>The ultrashort duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 10{sup 9}Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. 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F.</creatorcontrib><creatorcontrib>Kar, S.</creatorcontrib><creatorcontrib>School of Physics and Astronomy, University of Birmingham, B15 2TT</creatorcontrib><title>Biological cell irradiation at ultrahigh dose rate employing laser driven protons</title><title>AIP conference proceedings</title><description>The ultrashort duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 10{sup 9}Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4{+-}0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source.</description><subject>60 APPLIED LIFE SCIENCES</subject><subject>ANIMAL CELLS</subject><subject>BIOLOGICAL RADIATION EFFECTS</subject><subject>COMPARATIVE EVALUATIONS</subject><subject>DOSE RATES</subject><subject>DOSIMETRY</subject><subject>IRRADIATION</subject><subject>LASER RADIATION</subject><subject>MEV RANGE</subject><subject>PROTONS</subject><subject>RADIOBIOLOGY</subject><subject>RBE</subject><subject>X RADIATION</subject><issn>0094-243X</issn><issn>1551-7616</issn><fulltext>true</fulltext><rsrctype>conference_proceeding</rsrctype><creationdate>2012</creationdate><recordtype>conference_proceeding</recordtype><recordid>eNotzLtKBDEUANAgCo6rhX8QsJ41r8mdlLr4ggURFOyWbHJnJhKTJYmCf2-h1ekOIZecrTnT8pqvFUgNAEek48PAe9BcH5OOMaN6oeT7KTmr9YMxYQDGjrzchhzzHJyN1GGMNJRifbAt5ERto1-xFbuEeaE-V6TFNqT4eYj5J6SZRluxUF_CNyZ6KLnlVM_JyWRjxYt_V-Tt_u5189hvnx-eNjfbPvNRtt5JObrBgPEIzjPlYTI4qhE4M8C4F3tUErWBwUkU0oMy3AjrJo-D2U-TXJGrvzfXFnbVhYZucTkldG0nBNOGSSN_AeXEUR4</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>Doria, D.</creator><creator>Kakolee, K. 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F. ; Kar, S. ; School of Physics and Astronomy, University of Birmingham, B15 2TT</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-o183t-c338c5979de7cd04d7f9e8487109701d2be43e6975c3e23d749192acfde59bff3</frbrgroupid><rsrctype>conference_proceedings</rsrctype><prefilter>conference_proceedings</prefilter><language>eng</language><creationdate>2012</creationdate><topic>60 APPLIED LIFE SCIENCES</topic><topic>ANIMAL CELLS</topic><topic>BIOLOGICAL RADIATION EFFECTS</topic><topic>COMPARATIVE EVALUATIONS</topic><topic>DOSE RATES</topic><topic>DOSIMETRY</topic><topic>IRRADIATION</topic><topic>LASER RADIATION</topic><topic>MEV RANGE</topic><topic>PROTONS</topic><topic>RADIOBIOLOGY</topic><topic>RBE</topic><topic>X RADIATION</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Doria, D.</creatorcontrib><creatorcontrib>Kakolee, K. F.</creatorcontrib><creatorcontrib>Kar, S.</creatorcontrib><creatorcontrib>School of Physics and Astronomy, University of Birmingham, B15 2TT</creatorcontrib><collection>OSTI.GOV</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Doria, D.</au><au>Kakolee, K. F.</au><au>Kar, S.</au><au>School of Physics and Astronomy, University of Birmingham, B15 2TT</au><format>book</format><genre>proceeding</genre><ristype>CONF</ristype><atitle>Biological cell irradiation at ultrahigh dose rate employing laser driven protons</atitle><btitle>AIP conference proceedings</btitle><date>2012-01-01</date><risdate>2012</risdate><volume>1462</volume><issue>1</issue><issn>0094-243X</issn><eissn>1551-7616</eissn><abstract>The ultrashort duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 10{sup 9}Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4{+-}0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source.</abstract><cop>United States</cop><doi>10.1063/1.4736777</doi></addata></record> |
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| identifier | ISSN: 0094-243X |
| ispartof | AIP conference proceedings, 2012, Vol.1462 (1) |
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| source | AIP Journals Complete |
| subjects | 60 APPLIED LIFE SCIENCES ANIMAL CELLS BIOLOGICAL RADIATION EFFECTS COMPARATIVE EVALUATIONS DOSE RATES DOSIMETRY IRRADIATION LASER RADIATION MEV RANGE PROTONS RADIOBIOLOGY RBE X RADIATION |
| title | Biological cell irradiation at ultrahigh dose rate employing laser driven protons |
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