Complications of Microwave Ablation for Liver Tumors: Results of a Multicenter Study
Purpose New technologies for microwave ablation (MWA) have been conceived, designed to achieve larger areas of necrosis compared with radiofrequency ablation (RFA). The purpose of this study was to report complications by using this technique in patients with focal liver cancer. Methods Members of 1...
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| Veröffentlicht in: | Cardiovascular and interventional radiology 2012-08, Vol.35 (4), p.868-874 |
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| creator | Livraghi, Tito Meloni, Franca Solbiati, Luigi Zanus, Giorgio |
| description | Purpose
New technologies for microwave ablation (MWA) have been conceived, designed to achieve larger areas of necrosis compared with radiofrequency ablation (RFA). The purpose of this study was to report complications by using this technique in patients with focal liver cancer.
Methods
Members of 14 Italian centers used a 2.45-GMHz generator delivering energy through a cooled miniature-choke MW antenna and a standardized protocol for follow-up. They completed a questionnaire regarding number and type of deaths, major and minor complications and side effects, and likelihood of their relationship to the procedure. Enrollment included 736 patients with 1.037 lesions: 522 had hepatocellular carcinoma with cirrhosis, 187 had metastases predominantly from colorectal cancer, and 27 had cholangiocellular carcinoma. Tumor size ranged from 0.5 to 10 cm. In 13 centers, the approach used was percutaneous, in 4 videolaparoscopic, and in 3 laparotomic.
Results
No deaths were reported. Major complications occurred in 22 cases (2.9%), and minor complications in 54 patients (7.3%). Complications of MWA do not differ from those RFA, both being based on the heat damage.
Conclusion
Results of this multicenter study confirmed those of single-center experiences, indicating that MWA is a safe procedure, with no mortality and a low rate of major complications. The low rate of complications was probably due to precautions adopted, knowing in advance possible risk conditions, on the basis of prior RFA experience. |
| doi_str_mv | 10.1007/s00270-011-0241-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_osti_</sourceid><recordid>TN_cdi_osti_scitechconnect_22066593</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2713317771</sourcerecordid><originalsourceid>FETCH-LOGICAL-c466t-f439d49a6267ab3b863ba7cec92008f571d1738ec7cce8f034d98a98b908c8f53</originalsourceid><addsrcrecordid>eNp1kctOxCAUhonR6Dj6AG5MEzduqgfoBdyZibdkjImOiTtCKVVMW0agY3x70XrbuIJwvvMD50NoD8MRBiiPPQApIQWMUyAZTtkamuCMkhRY8bCOJoDLLMV5jrfQtvfPADhnJN9EWwQzShnwCVrMbLdsjZLB2N4ntkmujXL2Va50clq1n8dJY10yNyvtksXQWedPklvthzZ88jK5jlujdB8icBeG-m0HbTSy9Xr3a52i-_Ozxewynd9cXM1O56nKiiKkTUZ5nXFZkKKUFa1YQStZKq04AWBNXuIal5RpVSqlWQM0qzmTnFUcmIp1OkUHY671wQivTNDqSdm-1yoIQqAock4jdThSS2dfBu2D6IxXum1lr-3gBQbKco7jI34Df9BnO7g-_iFSEYAc4nynCI9UHJT3Tjdi6Uwn3VuExIcYMYoRUYz4ECNY7Nn_Sh6qTtc_Hd8mIkBGwMdS_6jd36v_S30H4mGWtg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1026705014</pqid></control><display><type>article</type><title>Complications of Microwave Ablation for Liver Tumors: Results of a Multicenter Study</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Livraghi, Tito ; Meloni, Franca ; Solbiati, Luigi ; Zanus, Giorgio</creator><creatorcontrib>Livraghi, Tito ; Meloni, Franca ; Solbiati, Luigi ; Zanus, Giorgio ; Collaborative Italian Group using AMICA system ; For the Collaborative Italian Group using AMICA system</creatorcontrib><description>Purpose
New technologies for microwave ablation (MWA) have been conceived, designed to achieve larger areas of necrosis compared with radiofrequency ablation (RFA). The purpose of this study was to report complications by using this technique in patients with focal liver cancer.
Methods
Members of 14 Italian centers used a 2.45-GMHz generator delivering energy through a cooled miniature-choke MW antenna and a standardized protocol for follow-up. They completed a questionnaire regarding number and type of deaths, major and minor complications and side effects, and likelihood of their relationship to the procedure. Enrollment included 736 patients with 1.037 lesions: 522 had hepatocellular carcinoma with cirrhosis, 187 had metastases predominantly from colorectal cancer, and 27 had cholangiocellular carcinoma. Tumor size ranged from 0.5 to 10 cm. In 13 centers, the approach used was percutaneous, in 4 videolaparoscopic, and in 3 laparotomic.
Results
No deaths were reported. Major complications occurred in 22 cases (2.9%), and minor complications in 54 patients (7.3%). Complications of MWA do not differ from those RFA, both being based on the heat damage.
Conclusion
Results of this multicenter study confirmed those of single-center experiences, indicating that MWA is a safe procedure, with no mortality and a low rate of major complications. The low rate of complications was probably due to precautions adopted, knowing in advance possible risk conditions, on the basis of prior RFA experience.</description><identifier>ISSN: 0174-1551</identifier><identifier>EISSN: 1432-086X</identifier><identifier>DOI: 10.1007/s00270-011-0241-8</identifier><identifier>PMID: 21833809</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>ABLATION ; Carcinoma, Hepatocellular - pathology ; Carcinoma, Hepatocellular - surgery ; Cardiology ; Catheter Ablation - methods ; Cholangiocarcinoma - pathology ; Cholangiocarcinoma - surgery ; Clinical Investigation ; DAMAGE ; DEATH ; Female ; HAZARDS ; HEAT ; HEPATOMAS ; Humans ; Imaging ; Italy - epidemiology ; Laparoscopy ; LIVER ; Liver Neoplasms - pathology ; Liver Neoplasms - surgery ; Male ; Medicine ; Medicine & Public Health ; METASTASES ; MICROWAVE RADIATION ; Microwaves - therapeutic use ; MORTALITY ; NECROSIS ; Nuclear Medicine ; PATIENTS ; Postoperative Complications - epidemiology ; RADIOLOGY ; RADIOLOGY AND NUCLEAR MEDICINE ; RADIOWAVE RADIATION ; SIDE EFFECTS ; Surveys and Questionnaires ; Ultrasound</subject><ispartof>Cardiovascular and interventional radiology, 2012-08, Vol.35 (4), p.868-874</ispartof><rights>Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2011</rights><rights>Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-f439d49a6267ab3b863ba7cec92008f571d1738ec7cce8f034d98a98b908c8f53</citedby><cites>FETCH-LOGICAL-c466t-f439d49a6267ab3b863ba7cec92008f571d1738ec7cce8f034d98a98b908c8f53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00270-011-0241-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00270-011-0241-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21833809$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/22066593$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Livraghi, Tito</creatorcontrib><creatorcontrib>Meloni, Franca</creatorcontrib><creatorcontrib>Solbiati, Luigi</creatorcontrib><creatorcontrib>Zanus, Giorgio</creatorcontrib><creatorcontrib>Collaborative Italian Group using AMICA system</creatorcontrib><creatorcontrib>For the Collaborative Italian Group using AMICA system</creatorcontrib><title>Complications of Microwave Ablation for Liver Tumors: Results of a Multicenter Study</title><title>Cardiovascular and interventional radiology</title><addtitle>Cardiovasc Intervent Radiol</addtitle><addtitle>Cardiovasc Intervent Radiol</addtitle><description>Purpose
New technologies for microwave ablation (MWA) have been conceived, designed to achieve larger areas of necrosis compared with radiofrequency ablation (RFA). The purpose of this study was to report complications by using this technique in patients with focal liver cancer.
Methods
Members of 14 Italian centers used a 2.45-GMHz generator delivering energy through a cooled miniature-choke MW antenna and a standardized protocol for follow-up. They completed a questionnaire regarding number and type of deaths, major and minor complications and side effects, and likelihood of their relationship to the procedure. Enrollment included 736 patients with 1.037 lesions: 522 had hepatocellular carcinoma with cirrhosis, 187 had metastases predominantly from colorectal cancer, and 27 had cholangiocellular carcinoma. Tumor size ranged from 0.5 to 10 cm. In 13 centers, the approach used was percutaneous, in 4 videolaparoscopic, and in 3 laparotomic.
Results
No deaths were reported. Major complications occurred in 22 cases (2.9%), and minor complications in 54 patients (7.3%). Complications of MWA do not differ from those RFA, both being based on the heat damage.
Conclusion
Results of this multicenter study confirmed those of single-center experiences, indicating that MWA is a safe procedure, with no mortality and a low rate of major complications. The low rate of complications was probably due to precautions adopted, knowing in advance possible risk conditions, on the basis of prior RFA experience.</description><subject>ABLATION</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Cardiology</subject><subject>Catheter Ablation - methods</subject><subject>Cholangiocarcinoma - pathology</subject><subject>Cholangiocarcinoma - surgery</subject><subject>Clinical Investigation</subject><subject>DAMAGE</subject><subject>DEATH</subject><subject>Female</subject><subject>HAZARDS</subject><subject>HEAT</subject><subject>HEPATOMAS</subject><subject>Humans</subject><subject>Imaging</subject><subject>Italy - epidemiology</subject><subject>Laparoscopy</subject><subject>LIVER</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Neoplasms - surgery</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>METASTASES</subject><subject>MICROWAVE RADIATION</subject><subject>Microwaves - therapeutic use</subject><subject>MORTALITY</subject><subject>NECROSIS</subject><subject>Nuclear Medicine</subject><subject>PATIENTS</subject><subject>Postoperative Complications - epidemiology</subject><subject>RADIOLOGY</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>RADIOWAVE RADIATION</subject><subject>SIDE EFFECTS</subject><subject>Surveys and Questionnaires</subject><subject>Ultrasound</subject><issn>0174-1551</issn><issn>1432-086X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kctOxCAUhonR6Dj6AG5MEzduqgfoBdyZibdkjImOiTtCKVVMW0agY3x70XrbuIJwvvMD50NoD8MRBiiPPQApIQWMUyAZTtkamuCMkhRY8bCOJoDLLMV5jrfQtvfPADhnJN9EWwQzShnwCVrMbLdsjZLB2N4ntkmujXL2Va50clq1n8dJY10yNyvtksXQWedPklvthzZ88jK5jlujdB8icBeG-m0HbTSy9Xr3a52i-_Ozxewynd9cXM1O56nKiiKkTUZ5nXFZkKKUFa1YQStZKq04AWBNXuIal5RpVSqlWQM0qzmTnFUcmIp1OkUHY671wQivTNDqSdm-1yoIQqAock4jdThSS2dfBu2D6IxXum1lr-3gBQbKco7jI34Df9BnO7g-_iFSEYAc4nynCI9UHJT3Tjdi6Uwn3VuExIcYMYoRUYz4ECNY7Nn_Sh6qTtc_Hd8mIkBGwMdS_6jd36v_S30H4mGWtg</recordid><startdate>20120801</startdate><enddate>20120801</enddate><creator>Livraghi, Tito</creator><creator>Meloni, Franca</creator><creator>Solbiati, Luigi</creator><creator>Zanus, Giorgio</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>20120801</creationdate><title>Complications of Microwave Ablation for Liver Tumors: Results of a Multicenter Study</title><author>Livraghi, Tito ; Meloni, Franca ; Solbiati, Luigi ; Zanus, Giorgio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-f439d49a6267ab3b863ba7cec92008f571d1738ec7cce8f034d98a98b908c8f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>ABLATION</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Carcinoma, Hepatocellular - surgery</topic><topic>Cardiology</topic><topic>Catheter Ablation - methods</topic><topic>Cholangiocarcinoma - pathology</topic><topic>Cholangiocarcinoma - surgery</topic><topic>Clinical Investigation</topic><topic>DAMAGE</topic><topic>DEATH</topic><topic>Female</topic><topic>HAZARDS</topic><topic>HEAT</topic><topic>HEPATOMAS</topic><topic>Humans</topic><topic>Imaging</topic><topic>Italy - epidemiology</topic><topic>Laparoscopy</topic><topic>LIVER</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver Neoplasms - surgery</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>METASTASES</topic><topic>MICROWAVE RADIATION</topic><topic>Microwaves - therapeutic use</topic><topic>MORTALITY</topic><topic>NECROSIS</topic><topic>Nuclear Medicine</topic><topic>PATIENTS</topic><topic>Postoperative Complications - epidemiology</topic><topic>RADIOLOGY</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>RADIOWAVE RADIATION</topic><topic>SIDE EFFECTS</topic><topic>Surveys and Questionnaires</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Livraghi, Tito</creatorcontrib><creatorcontrib>Meloni, Franca</creatorcontrib><creatorcontrib>Solbiati, Luigi</creatorcontrib><creatorcontrib>Zanus, Giorgio</creatorcontrib><creatorcontrib>Collaborative Italian Group using AMICA system</creatorcontrib><creatorcontrib>For the Collaborative Italian Group using AMICA system</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Cardiovascular and interventional radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Livraghi, Tito</au><au>Meloni, Franca</au><au>Solbiati, Luigi</au><au>Zanus, Giorgio</au><aucorp>Collaborative Italian Group using AMICA system</aucorp><aucorp>For the Collaborative Italian Group using AMICA system</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Complications of Microwave Ablation for Liver Tumors: Results of a Multicenter Study</atitle><jtitle>Cardiovascular and interventional radiology</jtitle><stitle>Cardiovasc Intervent Radiol</stitle><addtitle>Cardiovasc Intervent Radiol</addtitle><date>2012-08-01</date><risdate>2012</risdate><volume>35</volume><issue>4</issue><spage>868</spage><epage>874</epage><pages>868-874</pages><issn>0174-1551</issn><eissn>1432-086X</eissn><abstract>Purpose
New technologies for microwave ablation (MWA) have been conceived, designed to achieve larger areas of necrosis compared with radiofrequency ablation (RFA). The purpose of this study was to report complications by using this technique in patients with focal liver cancer.
Methods
Members of 14 Italian centers used a 2.45-GMHz generator delivering energy through a cooled miniature-choke MW antenna and a standardized protocol for follow-up. They completed a questionnaire regarding number and type of deaths, major and minor complications and side effects, and likelihood of their relationship to the procedure. Enrollment included 736 patients with 1.037 lesions: 522 had hepatocellular carcinoma with cirrhosis, 187 had metastases predominantly from colorectal cancer, and 27 had cholangiocellular carcinoma. Tumor size ranged from 0.5 to 10 cm. In 13 centers, the approach used was percutaneous, in 4 videolaparoscopic, and in 3 laparotomic.
Results
No deaths were reported. Major complications occurred in 22 cases (2.9%), and minor complications in 54 patients (7.3%). Complications of MWA do not differ from those RFA, both being based on the heat damage.
Conclusion
Results of this multicenter study confirmed those of single-center experiences, indicating that MWA is a safe procedure, with no mortality and a low rate of major complications. The low rate of complications was probably due to precautions adopted, knowing in advance possible risk conditions, on the basis of prior RFA experience.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>21833809</pmid><doi>10.1007/s00270-011-0241-8</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0174-1551 |
| ispartof | Cardiovascular and interventional radiology, 2012-08, Vol.35 (4), p.868-874 |
| issn | 0174-1551 1432-086X |
| language | eng |
| recordid | cdi_osti_scitechconnect_22066593 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | ABLATION Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - surgery Cardiology Catheter Ablation - methods Cholangiocarcinoma - pathology Cholangiocarcinoma - surgery Clinical Investigation DAMAGE DEATH Female HAZARDS HEAT HEPATOMAS Humans Imaging Italy - epidemiology Laparoscopy LIVER Liver Neoplasms - pathology Liver Neoplasms - surgery Male Medicine Medicine & Public Health METASTASES MICROWAVE RADIATION Microwaves - therapeutic use MORTALITY NECROSIS Nuclear Medicine PATIENTS Postoperative Complications - epidemiology RADIOLOGY RADIOLOGY AND NUCLEAR MEDICINE RADIOWAVE RADIATION SIDE EFFECTS Surveys and Questionnaires Ultrasound |
| title | Complications of Microwave Ablation for Liver Tumors: Results of a Multicenter Study |
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